hfe Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description hemochromatosis|The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3077)
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Genes

39 genes co-occuring with the biological term hfe in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACO1 aconitase 1, soluble
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
B2M beta-2-microglobulin
BMP2 bone morphogenetic protein 2
BMPR1A bone morphogenetic protein receptor, type IA
CCL2 chemokine (C-C motif) ligand 2
COMT catechol-O-methyltransferase
CP ceruloplasmin (ferroxidase)
CYBRD1 cytochrome b reductase 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
FTH1 ferritin, heavy polypeptide 1
FTL ferritin, light polypeptide
FURIN furin (paired basic amino acid cleaving enzyme)
GAST gastrin
HAMP hepcidin antimicrobial peptide
HBB hemoglobin, beta
HFE hemochromatosis
HFE2 hemochromatosis type 2 (juvenile)
HLA-A major histocompatibility complex, class I, A
IGF2R insulin-like growth factor 2 receptor
IREB2 iron-responsive element binding protein 2
MAPT microtubule-associated protein tau
MIR200A microRNA 200a
MIR200B microRNA 200b
MIR200C microRNA 200c
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
PCSK7 proprotein convertase subtilisin/kexin type 7
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PPP1R10 protein phosphatase 1, regulatory subunit 10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
TF transferrin
TFR2 transferrin receptor 2
TFRC transferrin receptor
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1