hif1a Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)|This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 3091)
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Genes

51 genes co-occuring with the biological term hif1a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACTN3 actinin, alpha 3 (gene/pseudogene)
APLN apelin
AR androgen receptor
ARNT aryl hydrocarbon receptor nuclear translocator
BIRC5 baculoviral IAP repeat containing 5
BOK BCL2-related ovarian killer
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD34 CD34 molecule
CDK8 cyclin-dependent kinase 8
CDKN2A cyclin-dependent kinase inhibitor 2A
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DPYSL3 dihydropyrimidinase-like 3
EGLN1 egl-9 family hypoxia-inducible factor 1
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FGF2 fibroblast growth factor 2 (basic)
FSCN1 fascin actin-bundling protein 1
GSTP1 glutathione S-transferase pi 1
HBEGF heparin-binding EGF-like growth factor
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HSF4 heat shock transcription factor 4
HSPA8 heat shock 70kDa protein 8
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MGMT O-6-methylguanine-DNA methyltransferase
MIR138-1 microRNA 138-1
MIR199A1 microRNA 199a-1
MIR210 microRNA 210
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NDRG1 N-myc downstream regulated 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFA platelet-derived growth factor alpha polypeptide
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PEPD peptidase D
PGF placental growth factor
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PROK1 prokineticin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RWDD3 RWD domain containing 3
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase