hippo signaling Gene Set
Dataset
GO Biological Process Annotations 2015
Category
structural or functional annotations
Type
biological process
Description
The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. (Gene Ontology , GO_0035329 )
External Link
http://amigo.geneontology.org/amigo/term/GO:0035329
Similar Terms
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Genes
26 genes participating in the hippo signaling biological process from the curated GO Biological Process Annotations 2015 dataset.
Symbol
Name
AMOT
angiomotin
AMOTL1
angiomotin like 1
AMOTL2
angiomotin like 2
CASP3
caspase 3, apoptosis-related cysteine peptidase
DCHS1
dachsous cadherin-related 1
DVL2
dishevelled segment polarity protein 2
FAT4
FAT atypical cadherin 4
LATS1
large tumor suppressor kinase 1
LATS2
large tumor suppressor kinase 2
MOB1A
MOB kinase activator 1A
MOB1B
MOB kinase activator 1B
NPHP4
nephronophthisis 4
SAV1
salvador family WW domain containing protein 1
STK3
serine/threonine kinase 3
STK4
serine/threonine kinase 4
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEAD2
TEA domain family member 2
TEAD3
TEA domain family member 3
TEAD4
TEA domain family member 4
TJP1
tight junction protein 1
TJP2
tight junction protein 2
WWC1
WW and C2 domain containing 1
WWTR1
WW domain containing transcription regulator 1
YAP1
Yes-associated protein 1
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
