histiocytosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A lymphatic system disease that is characterized by an excessive number of histiocytes. (Human Disease Ontology, DOID_3405)
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Genes

309 genes co-occuring with the disease histiocytosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.755
NPC1 Niemann-Pick disease, type C1 2.5589
CD68 CD68 molecule 2.51843
NPC2 Niemann-Pick disease, type C2 2.35356
LYZ lysozyme 2.02431
CD1A CD1a molecule 1.7546
CD207 CD207 molecule, langerin 1.68634
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 1.67819
CD163 CD163 molecule 1.47682
S100A9 S100 calcium binding protein A9 1.432
ACPP acid phosphatase, prostate 1.40483
FSCN3 fascin actin-bundling protein 3, testicular 1.39564
FSCN1 fascin actin-bundling protein 1 1.37469
FSCN2 fascin actin-bundling protein 2, retinal 1.36509
CHIT1 chitinase 1 (chitotriosidase) 1.25037
PGM1 phosphoglucomutase 1 1.20569
HAVCR1 hepatitis A virus cellular receptor 1 1.19704
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.1422
PTPRC protein tyrosine phosphatase, receptor type, C 1.11645
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 1.09671
CD34 CD34 molecule 1.07992
CD1C CD1c molecule 1.02945
NPB neuropeptide B 1.02144
AVP arginine vasopressin 0.996127
CD4 CD4 molecule 0.941196
HEXA hexosaminidase A (alpha polypeptide) 0.925452
CSF1R colony stimulating factor 1 receptor 0.908553
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.863456
OAT ornithine aminotransferase 0.848307
M6PR mannose-6-phosphate receptor (cation dependent) 0.836837
UGCG UDP-glucose ceramide glucosyltransferase 0.828639
STAB1 stabilin 1 0.804436
NCAM1 neural cell adhesion molecule 1 0.803205
RAB9A RAB9A, member RAS oncogene family 0.801154
IL1RN interleukin 1 receptor antagonist 0.760639
FTL ferritin, light polypeptide 0.73746
FTH1 ferritin, heavy polypeptide 1 0.711989
DEAF1 DEAF1 transcription factor 0.71078
ARAF A-Raf proto-oncogene, serine/threonine kinase 0.706351
CD79A CD79a molecule, immunoglobulin-associated alpha 0.693098
NPC1L1 NPC1-like 1 0.686691
STX11 syntaxin 11 0.678302
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.674713
CD1B CD1b molecule 0.66199
IL2RA interleukin 2 receptor, alpha 0.634742
PPL periplakin 0.63042
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.629635
ALPPL2 alkaline phosphatase, placental-like 2 0.608885
ALPP alkaline phosphatase, placental 0.608494
ALPL alkaline phosphatase, liver/bone/kidney 0.607714
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.607323
GDI2 GDP dissociation inhibitor 2 0.595233
PLA2G15 phospholipase A2, group XV 0.593285
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.582773
CRNN cornulin 0.573828
COX6CP4 cytochrome c oxidase subunit VIc pseudogene 4 0.571495
KIAA1549 KIAA1549 0.571495
CD7 CD7 molecule 0.562558
TARM1 T cell-interacting, activating receptor on myeloid cells 1 0.55712
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 0.546644
WDR76 WD repeat domain 76 0.538118
HBA2 hemoglobin, alpha 2 0.530381
CD5 CD5 molecule 0.527676
CD83 CD83 molecule 0.509959
LCAT lecithin-cholesterol acyltransferase 0.509192
GUSB glucuronidase, beta 0.504207
GBA glucosidase, beta, acid 0.498085
HBA1 hemoglobin, alpha 1 0.47753
CSDE1 cold shock domain containing E1, RNA-binding 0.473361
FXYD5 FXYD domain containing ion transport regulator 5 0.471468
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.469954
CD101 CD101 molecule 0.46655
APOD apolipoprotein D 0.463149
CCNB3 cyclin B3 0.446182
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.445805
CTSE cathepsin E 0.435275
IGKC immunoglobulin kappa constant 0.435275
PCNA proliferating cell nuclear antigen 0.434148
MIR4315-1 microRNA 4315-1 0.431519
MIR4315-2 microRNA 4315-2 0.431519
TNF tumor necrosis factor 0.429266
MAP2K1 mitogen-activated protein kinase kinase 1 0.413527
PRSS30P protease, serine, 30, pseudogene 0.408666
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.407919
TFRC transferrin receptor 0.403811
ICAM1 intercellular adhesion molecule 1 0.399707
MFSD10 major facilitator superfamily domain containing 10 0.391141
THY1 Thy-1 cell surface antigen 0.389653
CD58 CD58 molecule 0.385193
SH2D1A SH2 domain containing 1A 0.384822
CCR7 chemokine (C-C motif) receptor 7 0.381481
ENO2 enolase 2 (gamma, neuronal) 0.378885
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.377773
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.37629
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.36704
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 0.361502
AR androgen receptor 0.356341
IL1B interleukin 1, beta 0.354868
UNC13D unc-13 homolog D (C. elegans) 0.352659
GAA glucosidase, alpha; acid 0.350084
PSAP prosaposin 0.349349
IL1A interleukin 1, alpha 0.348981
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 0.347144
HRAS Harvey rat sarcoma viral oncogene homolog 0.346409
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.345308
SART3 squamous cell carcinoma antigen recognized by T cells 3 0.342739
SLC38A5 solute carrier family 38, member 5 0.341272
MMP12 matrix metallopeptidase 12 0.339073
SEBOX SEBOX homeobox 0.335412
CTSB cathepsin B 0.331391
DSP desmoplakin 0.331391
UGT8 UDP glycosyltransferase 8 0.328834
TP53 tumor protein p53 0.328469
IRX2 iroquois homeobox 2 0.322637
ALK anaplastic lymphoma receptor tyrosine kinase 0.320817
LY96 lymphocyte antigen 96 0.319726
VIM vimentin 0.313189
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.294413
AHSG alpha-2-HS-glycoprotein 0.284371
ARSH arylsulfatase family, member H 0.282582
FGR FGR proto-oncogene, Src family tyrosine kinase 0.278654
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.275801
NF1 neurofibromin 1 0.272241
ITSN1 intersectin 1 (SH3 domain protein) 0.271174
CCR6 chemokine (C-C motif) receptor 6 0.271174
GALC galactosylceramidase 0.268332
CXCL13 chemokine (C-X-C motif) ligand 13 0.264431
EVPL envoplakin 0.261599
HCRT hypocretin (orexin) neuropeptide precursor 0.258417
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 0.256652
IL2 interleukin 2 0.253479
GAL3ST1 galactose-3-O-sulfotransferase 1 0.250663
MPO myeloperoxidase 0.248905
ITGAD integrin, alpha D 0.246448
CD38 CD38 molecule 0.246098
IFNE interferon, epsilon 0.240497
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.240497
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.235964
GLB1 galactosidase, beta 1 0.227642
GSN gelsolin 0.225229
CCL20 chemokine (C-C motif) ligand 20 0.22454
PHYH phytanoyl-CoA 2-hydroxylase 0.223853
MLANA melan-A 0.223165
SCARB1 scavenger receptor class B, member 1 0.217012
F8 coagulation factor VIII, procoagulant component 0.215314
LPA lipoprotein, Lp(a) 0.214975
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.208914
APOE apolipoprotein E 0.207912
TIMD4 T-cell immunoglobulin and mucin domain containing 4 0.207912
IFNGR1 interferon gamma receptor 1 0.202946
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 0.200982
CD80 CD80 molecule 0.197742
TMPRSS13 transmembrane protease, serine 13 0.192971
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.192031
CRP C-reactive protein, pentraxin-related 0.188938
BIN2 bridging integrator 2 0.187719
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.184424
SREBF1 sterol regulatory element binding transcription factor 1 0.182086
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.18151
MRC1 mannose receptor, C type 1 0.178403
CALB1 calbindin 1, 28kDa 0.177576
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.177301
PDGFB platelet-derived growth factor beta polypeptide 0.176757
ARSA arylsulfatase A 0.176215
APOA1 apolipoprotein A-I 0.174881
ICAM3 intercellular adhesion molecule 3 0.172544
GHRH growth hormone releasing hormone 0.172291
LDLR low density lipoprotein receptor 0.172038
PVALB parvalbumin 0.172038
PIDD1 p53-induced death domain protein 1 0.172038
GFAP glial fibrillary acidic protein 0.171785
INSIG1 insulin induced gene 1 0.170054
SCARB2 scavenger receptor class B, member 2 0.169091
POMC proopiomelanocortin 0.168617
CTSK cathepsin K 0.167224
CCL19 chemokine (C-C motif) ligand 19 0.165874
PROS1 protein S (alpha) 0.162306
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.161139
KRAS Kirsten rat sarcoma viral oncogene homolog 0.160574
CD36 CD36 molecule (thrombospondin receptor) 0.160203
CTSD cathepsin D 0.159838
CDK5 cyclin-dependent kinase 5 0.15948
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.15948
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.158778
CD86 CD86 molecule 0.157765
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.142021
JMJD6 jumonji domain containing 6 0.141405
DCK deoxycytidine kinase 0.138905
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.138654
LY75 lymphocyte antigen 75 0.137124
NELFCD negative elongation factor complex member C/D 0.13626
CD209 CD209 molecule 0.13491
DCD dermcidin 0.132781
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.130464
SOAT1 sterol O-acyltransferase 1 0.130358
GM2A GM2 ganglioside activator 0.130122
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.129994
CTSS cathepsin S 0.129732
IL6ST interleukin 6 signal transducer 0.12887
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.128029
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.127709
CAV1 caveolin 1, caveolae protein, 22kDa 0.127129
MT3 metallothionein 3 0.126065
LAMP1 lysosomal-associated membrane protein 1 0.125889
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.125529
RHCE Rh blood group, CcEe antigens 0.125254
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 0.125053
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.124493
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.124424
KIF11 kinesin family member 11 0.123913
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.123799
NAGLU N-acetylglucosaminidase, alpha 0.123475
TPP1 tripeptidyl peptidase I 0.122874
TRADD TNFRSF1A-associated via death domain 0.122156
APTX aprataxin 0.121933
NAGA N-acetylgalactosaminidase, alpha- 0.12177
KLK8 kallikrein-related peptidase 8 0.121311
SKAP2 src kinase associated phosphoprotein 2 0.120667
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.120265
RHD Rh blood group, D antigen 0.120178
SI sucrase-isomaltase (alpha-glucosidase) 0.119967
SORT1 sortilin 1 0.119092
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.11828
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.118183
MITF microphthalmia-associated transcription factor 0.115492
FGF19 fibroblast growth factor 19 0.113781
LMO2 LIM domain only 2 (rhombotin-like 1) 0.112466
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.112299
SARS seryl-tRNA synthetase 0.111666
TPM3 tropomyosin 3 0.110314
CALD1 caldesmon 1 0.109094
FBXO17 F-box protein 17 0.108557
FOXO4 forkhead box O4 0.108369
LONP1 lon peptidase 1, mitochondrial 0.107246
KITLG KIT ligand 0.106686
PRDM16 PR domain containing 16 0.106403
PAX5 paired box 5 0.106148
HECA headcase homolog (Drosophila) 0.104698
ALYREF Aly/REF export factor 0.104668
PLIN2 perilipin 2 0.104459
IVL involucrin 0.102858
BCL2A1 BCL2-related protein A1 0.102304
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.101802
IL11 interleukin 11 0.101614
AVPR2 arginine vasopressin receptor 2 0.101583
B3GAT1 beta-1,3-glucuronyltransferase 1 0.10152
ADRB1 adrenoceptor beta 1 0.100981
GPR83 G protein-coupled receptor 83 0.100756
TRH thyrotropin-releasing hormone 0.100404
LDHAL6B lactate dehydrogenase A-like 6B 0.100211
TMC6 transmembrane channel-like 6 0.100147
FOXP3 forkhead box P3 0.099592
ANXA3 annexin A3 0.098671
DUX4L8 double homeobox 4 like 8 0.097766
BCOR BCL6 corepressor 0.097292
PAX2 paired box 2 0.097018
CYS1 cystin 1 0.096915
PGK1 phosphoglycerate kinase 1 0.096299
CCNB1 cyclin B1 0.095987
THEM4 thioesterase superfamily member 4 0.095847
FABP3 fatty acid binding protein 3, muscle and heart 0.095357
DEK DEK proto-oncogene 0.095078
LDHAL6A lactate dehydrogenase A-like 6A 0.095043
CCR1 chemokine (C-C motif) receptor 1 0.09437
DUX4L6 double homeobox 4 like 6 0.094156
EWSR1 EWS RNA-binding protein 1 0.093942
CCL1 chemokine (C-C motif) ligand 1 0.093116
TCN2 transcobalamin II 0.092862
PMEL premelanosome protein 0.091878
FGFR1 fibroblast growth factor receptor 1 0.091287
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.090395
CCL4 chemokine (C-C motif) ligand 4 0.090395
H3F3A H3 histone, family 3A 0.089719
H3F3B H3 histone, family 3B (H3.3B) 0.089719
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.089343
CST4 cystatin S 0.088886
LPP LIM domain containing preferred translocation partner in lipoma 0.088657
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.08839
SIX3 SIX homeobox 3 0.088314
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.08797
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.087624
CCR3 chemokine (C-C motif) receptor 3 0.087275
CD40LG CD40 ligand 0.087275
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.087197
LRP6 low density lipoprotein receptor-related protein 6 0.08712
IFNA2 interferon, alpha 2 0.087042
IL10 interleukin 10 0.086771
DSPP dentin sialophosphoprotein 0.086655
S100B S100 calcium binding protein B 0.086616
JAG2 jagged 2 0.0865
CD40 CD40 molecule, TNF receptor superfamily member 5 0.086461
SPP1 secreted phosphoprotein 1 0.086306
HLA-A major histocompatibility complex, class I, A 0.085598
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 0.085519
CLDN5 claudin 5 0.084653
POU5F1 POU class 5 homeobox 1 0.084533
CNOT2 CCR4-NOT transcription complex, subunit 2 0.084533
UROS uroporphyrinogen III synthase 0.084493
SP100 SP100 nuclear antigen 0.084334
HMGA2 high mobility group AT-hook 2 0.083537
MKI67 marker of proliferation Ki-67 0.083137
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.082733
APOB apolipoprotein B 0.082733
LDHC lactate dehydrogenase C 0.082572
WDFY2 WD repeat and FYVE domain containing 2 0.082572
HSPA4 heat shock 70kDa protein 4 0.082047
RARA retinoic acid receptor, alpha 0.081725
STAR steroidogenic acute regulatory protein 0.08148
GALNS galactosamine (N-acetyl)-6-sulfatase 0.080949