homatropine-5058 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the homatropine-5058 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
AGRP agouti related neuropeptide
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALK anaplastic lymphoma receptor tyrosine kinase
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C11ORF16 chromosome 11 open reading frame 16
CAPZB capping protein (actin filament) muscle Z-line, beta
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASQ2 calsequestrin 2 (cardiac muscle)
CCNO cyclin O
CDRT1 CMT1A duplicated region transcript 1
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL21A1 collagen, type XXI, alpha 1
CTNND2 catenin (cadherin-associated protein), delta 2
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR6 chemokine (C-X-C motif) receptor 6
CYTH4 cytohesin 4
DIAPH2 diaphanous-related formin 2
DIO2 deiodinase, iodothyronine, type II
DLX4 distal-less homeobox 4
ESR1 estrogen receptor 1
F5 coagulation factor V (proaccelerin, labile factor)
FBXL15 F-box and leucine-rich repeat protein 15
FGF9 fibroblast growth factor 9
GAB1 GRB2-associated binding protein 1
GAL galanin/GMAP prepropeptide
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GLB1L galactosidase, beta 1-like
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM7 glutamate receptor, metabotropic 7
GSN-AS1 GSN antisense RNA 1
GTDC1 glycosyltransferase-like domain containing 1
HMHB1 histocompatibility (minor) HB-1
HOXC11 homeobox C11
HOXD11 homeobox D11
IL11 interleukin 11
ITGB7 integrin, beta 7
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KCTD17 potassium channel tetramerization domain containing 17
KLHL25 kelch-like family member 25
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
MAPK11 mitogen-activated protein kinase 11
MCTP2 multiple C2 domains, transmembrane 2
MFAP3L microfibrillar-associated protein 3-like
MMP25 matrix metallopeptidase 25
MOBP myelin-associated oligodendrocyte basic protein
MSI1 musashi RNA-binding protein 1
MST1 macrophage stimulating 1
MTAP methylthioadenosine phosphorylase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NCAM1 neural cell adhesion molecule 1
NF1 neurofibromin 1
NRP2 neuropilin 2
OGG1 8-oxoguanine DNA glycosylase
OSBPL10 oxysterol binding protein-like 10
PLXDC1 plexin domain containing 1
PML promyelocytic leukemia
POM121 POM121 transmembrane nucleoporin
POU2F2 POU class 2 homeobox 2
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRSS50 protease, serine, 50
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB2A RAB2A, member RAS oncogene family
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGS10 regulator of G-protein signaling 10
RNF122 ring finger protein 122
RNF17 ring finger protein 17
RPL35A ribosomal protein L35a
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCN10A sodium channel, voltage gated, type X alpha subunit
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
STAT5B signal transducer and activator of transcription 5B
SURF1 surfeit 1
TBC1D30 TBC1 domain family, member 30
TBX6 T-box 6
TBXA2R thromboxane A2 receptor
THOC5 THO complex 5
TRIM33 tripartite motif containing 33
VGF VGF nerve growth factor inducible
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
WNK1 WNK lysine deficient protein kinase 1
XAB2 XPA binding protein 2
ZFHX2 zinc finger homeobox 2
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
AHCTF1 AT hook containing transcription factor 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ASAP1-IT1 ASAP1 intronic transcript 1
ASTE1 asteroid homolog 1 (Drosophila)
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BHLHB9 basic helix-loop-helix domain containing, class B, 9
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC68 coiled-coil domain containing 68
CCNJL cyclin J-like
CDH7 cadherin 7, type 2
CDKN2AIP CDKN2A interacting protein
CFAP44 cilia and flagella associated protein 44
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHM choroideremia (Rab escort protein 1)
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CSRNP3 cysteine-serine-rich nuclear protein 3
CXCL3 chemokine (C-X-C motif) ligand 3
DCAF13 DDB1 and CUL4 associated factor 13
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DENND4C DENN/MADD domain containing 4C
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
EDIL3 EGF-like repeats and discoidin I-like domains 3
EHD3 EH-domain containing 3
EHF ets homologous factor
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ETNK2 ethanolamine kinase 2
FKBP5 FK506 binding protein 5
FZD8 frizzled class receptor 8
GALT galactose-1-phosphate uridylyltransferase
GMEB1 glucocorticoid modulatory element binding protein 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2I general transcription factor IIi
HLX H2.0-like homeobox
IPO8 importin 8
KCTD20 potassium channel tetramerization domain containing 20
LIG4 ligase IV, DNA, ATP-dependent
LOC100286895 cell division cycle 27 homolog pseudogene
METRN meteorin, glial cell differentiation regulator
METTL16 methyltransferase like 16
MFSD6 major facilitator superfamily domain containing 6
MIS18BP1 MIS18 binding protein 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NPM3 nucleophosmin/nucleoplasmin 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PMCH pro-melanin-concentrating hormone
POLM polymerase (DNA directed), mu
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKCE protein kinase C, epsilon
PWAR5 Prader Willi/Angelman region RNA 5
R3HCC1L R3H domain and coiled-coil containing 1-like
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
REEP4 receptor accessory protein 4
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF2 ring finger protein 2
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RSRC1 arginine/serine-rich coiled-coil 1
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SCYL2 SCY1-like 2 (S. cerevisiae)
SERGEF secretion regulating guanine nucleotide exchange factor
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC41A3 solute carrier family 41, member 3
SLITRK5 SLIT and NTRK-like family, member 5
SMAD7 SMAD family member 7
SNPH syntaphilin
SNX16 sorting nexin 16
SOBP sine oculis binding protein homolog (Drosophila)
SPIDR scaffolding protein involved in DNA repair
SPIN1 spindlin 1
SPTBN2 spectrin, beta, non-erythrocytic 2
STAC SH3 and cysteine rich domain
STRN striatin, calmodulin binding protein
SYNPO synaptopodin
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM2 transmembrane protein 2
TMEM209 transmembrane protein 209
TMEM260 transmembrane protein 260
TRIM9 tripartite motif containing 9
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UGT8 UDP glycosyltransferase 8
UTRN utrophin
ZFP69B ZFP69 zinc finger protein B
ZNF254 zinc finger protein 254
ZNF276 zinc finger protein 276
ZNF37BP zinc finger protein 37B, pseudogene
ZNF408 zinc finger protein 408
ZNF552 zinc finger protein 552
ZNHIT2 zinc finger, HIT-type containing 2
ZXDC ZXD family zinc finger C