hsa-miR-569 Gene Set

Dataset TargetScan Predicted Nonconserved microRNA Targets
Category genomics
Type microRNA
Description microRNA 569|microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 693154)
External Link http://www.targetscan.org/cgi-bin/targetscan/vert_70/targetscan.cgi?mirg=hsa-miR-569
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Genes

348 target genes of the hsa-miR-569 microRNA predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.

Symbol Name Standardized Value
CNGA3 cyclic nucleotide gated channel alpha 3 1.99187
MFSD4 major facilitator superfamily domain containing 4 1.99187
KIAA1033 KIAA1033 1.99187
ZNF558 zinc finger protein 558 1.99187
TUBA1B tubulin, alpha 1b 1.99187
KANSL3 KAT8 regulatory NSL complex subunit 3 1.99187
FAM161B family with sequence similarity 161, member B 1.99187
ZNF687 zinc finger protein 687 1.99187
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 1.99187
WWP2 WW domain containing E3 ubiquitin protein ligase 2 1.99187
C12ORF40 chromosome 12 open reading frame 40 1.99187
COPA coatomer protein complex, subunit alpha 1.99187
BET1L Bet1 golgi vesicular membrane trafficking protein-like 1.99187
DEPTOR DEP domain containing MTOR-interacting protein 1.99187
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 1.99187
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 1.99187
PNPLA8 patatin-like phospholipase domain containing 8 1.99187
CNGB1 cyclic nucleotide gated channel beta 1 1.99187
PCDHA9 protocadherin alpha 9 1.99187
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) 1.99187
CLDN1 claudin 1 1.99187
SKA3 spindle and kinetochore associated complex subunit 3 1.99187
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 1.7397
SMIM9 small integral membrane protein 9 1.7397
COA5 cytochrome c oxidase assembly factor 5 1.7397
C1ORF174 chromosome 1 open reading frame 174 1.7397
TDP1 tyrosyl-DNA phosphodiesterase 1 1.7397
C14ORF28 chromosome 14 open reading frame 28 1.7397
TRAPPC2 trafficking protein particle complex 2 1.7397
MTMR6 myotubularin related protein 6 1.7397
TIGD6 tigger transposable element derived 6 1.7397
CP ceruloplasmin (ferroxidase) 1.7397
SCNM1 sodium channel modifier 1 1.7397
RSBN1L round spermatid basic protein 1-like 1.7397
RGS13 regulator of G-protein signaling 13 1.7397
WNT2 wingless-type MMTV integration site family member 2 1.7397
TMEM223 transmembrane protein 223 1.7397
TYW5 tRNA-yW synthesizing protein 5 1.7397
RNF182 ring finger protein 182 1.7397
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 1.7397
GPR82 G protein-coupled receptor 82 1.7397
FER fer (fps/fes related) tyrosine kinase 1.7397
MYF6 myogenic factor 6 (herculin) 1.7397
ANO10 anoctamin 10 1.7397
C5ORF45 chromosome 5 open reading frame 45 1.7397
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) 1.55165
ZNF506 zinc finger protein 506 1.55165
NANOGNB NANOG neighbor homeobox 1.55165
APAF1 apoptotic peptidase activating factor 1 1.55165
THAP10 THAP domain containing 10 1.55165
ZNF814 zinc finger protein 814 1.55165
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 1.55165
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 1.55165
BTN3A3 butyrophilin, subfamily 3, member A3 1.55165
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 1.55165
ARMC2 armadillo repeat containing 2 1.55165
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 1.55165
AVPR1A arginine vasopressin receptor 1A 1.55165
FGF9 fibroblast growth factor 9 1.55165
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 1.55165
ZNF571 zinc finger protein 571 1.55165
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 1.55165
RRM2 ribonucleotide reductase M2 1.55165
NRG1 neuregulin 1 1.55165
SEC23IP SEC23 interacting protein 1.55165
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 1.55165
RAB39A RAB39A, member RAS oncogene family 1.55165
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.55165
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 1.40969
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 1.40969
RBM12B RNA binding motif protein 12B 1.40969
SLC15A5 solute carrier family 15, member 5 1.40969
LPAR6 lysophosphatidic acid receptor 6 1.40969
SLC39A12 solute carrier family 39 (zinc transporter), member 12 1.40969
NOTCH2NL notch 2 N-terminal like 1.40969
ENDOU endonuclease, polyU-specific 1.40969
NPAT nuclear protein, ataxia-telangiectasia locus 1.40969
ZFP36L1 ZFP36 ring finger protein-like 1 1.40969
FAM192A family with sequence similarity 192, member A 1.40969
PPP1R9A protein phosphatase 1, regulatory subunit 9A 1.40969
KLF8 Kruppel-like factor 8 1.40969
VEZT vezatin, adherens junctions transmembrane protein 1.40969
PCDHB3 protocadherin beta 3 1.40969
ENAM enamelin 1.40969
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 1.40969
AQP4 aquaporin 4 1.40969
BTNL3 butyrophilin-like 3 1.40969
RAD51B RAD51 paralog B 1.40969
ZNF277 zinc finger protein 277 1.40969
SH3GLB1 SH3-domain GRB2-like endophilin B1 1.40969
ZNF229 zinc finger protein 229 1.40969
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 1.40969
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 1.2992
PRR16 proline rich 16 1.2992
SPARCL1 SPARC-like 1 (hevin) 1.2992
ORC4 origin recognition complex, subunit 4 1.2992
MMD2 monocyte to macrophage differentiation-associated 2 1.2992
SKIL SKI-like proto-oncogene 1.2992
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.2992
ALS2CR11 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 1.2992
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.2992
SRPK2 SRSF protein kinase 2 1.2992
UBE2J1 ubiquitin-conjugating enzyme E2, J1 1.2992
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 1.2992
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1.2992
PDZK1 PDZ domain containing 1 1.2992
SCAF11 SR-related CTD-associated factor 11 1.2992
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 1.2992
MFF mitochondrial fission factor 1.2992
SNX4 sorting nexin 4 1.2992
ATP11A ATPase, class VI, type 11A 1.2992
GMFB glia maturation factor, beta 1.2992
COX18 COX18 cytochrome c oxidase assembly factor 1.2992
CCPG1 cell cycle progression 1 1.2992
DPP9-AS1 DPP9 antisense RNA 1 1.2992
RFX3 regulatory factor X, 3 (influences HLA class II expression) 1.2992
STRIP2 striatin interacting protein 2 1.20993
WNT16 wingless-type MMTV integration site family, member 16 1.20993
IFT57 intraflagellar transport 57 1.20993
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 1.20993
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 1.20993
CNGA1 cyclic nucleotide gated channel alpha 1 1.20993
DEAF1 DEAF1 transcription factor 1.20993
C1D C1D nuclear receptor corepressor 1.20993
C6ORF222 chromosome 6 open reading frame 222 1.20993
TCAIM T cell activation inhibitor, mitochondrial 1.20993
NUSAP1 nucleolar and spindle associated protein 1 1.20993
ACTA1 actin, alpha 1, skeletal muscle 1.20993
CLU clusterin 1.20993
ZNF793 zinc finger protein 793 1.20993
ZNF561 zinc finger protein 561 1.20993
TINAG tubulointerstitial nephritis antigen 1.20993
PRUNE2 prune homolog 2 (Drosophila) 1.20993
CCR3 chemokine (C-C motif) receptor 3 1.20993
VWA8 von Willebrand factor A domain containing 8 1.20993
NIFK nucleolar protein interacting with the FHA domain of MKI67 1.20993
SNX31 sorting nexin 31 1.20993
POT1 protection of telomeres 1 1.20993
FAM76B family with sequence similarity 76, member B 1.20993
HOMEZ homeobox and leucine zipper encoding 1.20993
NXNL2 nucleoredoxin-like 2 1.13535
ZNF280C zinc finger protein 280C 1.13535
CNGB3 cyclic nucleotide gated channel beta 3 1.13535
FUT10 fucosyltransferase 10 (alpha (1,3) fucosyltransferase) 1.13535
STAC SH3 and cysteine rich domain 1.13535
CCNG2 cyclin G2 1.13535
DRAM1 DNA-damage regulated autophagy modulator 1 1.13535
RBM24 RNA binding motif protein 24 1.13535
RNF6 ring finger protein (C3H2C3 type) 6 1.13535
TTC3 tetratricopeptide repeat domain 3 1.13535
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 1.13535
PDZD2 PDZ domain containing 2 1.13535
UST uronyl-2-sulfotransferase 1.13535
IRGQ immunity-related GTPase family, Q 1.13535
PCYOX1 prenylcysteine oxidase 1 1.13535
TSLP thymic stromal lymphopoietin 1.13535
KLHL8 kelch-like family member 8 1.13535
TBX3 T-box 3 1.13535
WNK3 WNK lysine deficient protein kinase 3 1.13535
TTC22 tetratricopeptide repeat domain 22 1.13535
OOSP2 oocyte secreted protein 2 1.13535
KATNBL1 katanin p80 subunit B-like 1 1.13535
BIN2 bridging integrator 2 1.13535
SPDYA speedy/RINGO cell cycle regulator family member A 1.13535
WDR17 WD repeat domain 17 1.13535
ZNF547 zinc finger protein 547 1.07142
NIPSNAP3A nipsnap homolog 3A (C. elegans) 1.07142
NIPSNAP3B nipsnap homolog 3B (C. elegans) 1.07142
PRNP prion protein 1.07142
WDR26 WD repeat domain 26 1.07142
RAB39B RAB39B, member RAS oncogene family 1.07142
TWISTNB TWIST neighbor 1.07142
C10ORF12 chromosome 10 open reading frame 12 1.07142
ITCH itchy E3 ubiquitin protein ligase 1.07142
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 1.07142
CAV2 caveolin 2 1.07142
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 1.07142
ANXA6 annexin A6 1.07142
C1ORF106 chromosome 1 open reading frame 106 1.07142
FAM160B1 family with sequence similarity 160, member B1 1.07142
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 1.07142
TRPC5OS TRPC5 opposite strand 1.07142
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila) 1.07142
KANSL1L KAT8 regulatory NSL complex subunit 1-like 1.07142
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 1.07142
DPY19L3 dpy-19-like 3 (C. elegans) 1.07142
TMEM86A transmembrane protein 86A 1.07142
FUNDC2 FUN14 domain containing 2 1.07142
GNRHR gonadotropin-releasing hormone receptor 1.07142
RABL2A RAB, member of RAS oncogene family-like 2A 1.0155
PLCH1 phospholipase C, eta 1 1.0155
ZNF529 zinc finger protein 529 1.0155
LUC7L2 LUC7-like 2 (S. cerevisiae) 1.0155
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.0155
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 1.0155
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 1.0155
PAPOLB poly(A) polymerase beta (testis specific) 1.0155
PAPOLA poly(A) polymerase alpha 1.0155
MCM10 minichromosome maintenance complex component 10 1.0155
RPAIN RPA interacting protein 1.0155
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 1.0155
LYRM5 LYR motif containing 5 1.0155
TMEM144 transmembrane protein 144 1.0155
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 1.0155
PCGF3 polycomb group ring finger 3 1.0155
ANGPTL3 angiopoietin-like 3 1.0155
DAZAP2 DAZ associated protein 2 1.0155
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 1.0155
FBXL5 F-box and leucine-rich repeat protein 5 1.0155
CBR4 carbonyl reductase 4 1.0155
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 1.0155
PARP14 poly (ADP-ribose) polymerase family, member 14 1.0155
DTWD2 DTW domain containing 2 1.0155
MSTN myostatin 1.0155
WDR36 WD repeat domain 36 0.965816
MAP3K19 mitogen-activated protein kinase kinase kinase 19 0.965816
ZBTB33 zinc finger and BTB domain containing 33 0.965816
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 0.965816
MAPK1 mitogen-activated protein kinase 1 0.965816
C5ORF28 chromosome 5 open reading frame 28 0.965816
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 0.965816
OSMR oncostatin M receptor 0.965816
HSDL2 hydroxysteroid dehydrogenase like 2 0.965816
SCIN scinderin 0.965816
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.965816
UBA5 ubiquitin-like modifier activating enzyme 5 0.965816
SPHKAP SPHK1 interactor, AKAP domain containing 0.965816
SIGLEC5 sialic acid binding Ig-like lectin 5 0.965816
ASF1A anti-silencing function 1A histone chaperone 0.965816
CSNK1A1L casein kinase 1, alpha 1-like 0.965816
RNMT RNA (guanine-7-) methyltransferase 0.965816
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.965816
PIBF1 progesterone immunomodulatory binding factor 1 0.965816
CEP162 centrosomal protein 162kDa 0.965816
PLN phospholamban 0.965816
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.965816
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.965816
RABL2B RAB, member of RAS oncogene family-like 2B 0.965816
SYNM synemin, intermediate filament protein 0.965816
BFAR bifunctional apoptosis regulator 0.965816
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 0.965816
ASB9 ankyrin repeat and SOCS box containing 9 0.965816
TIFA TRAF-interacting protein with forkhead-associated domain 0.921135
EGF epidermal growth factor 0.921135
ANXA8L1 annexin A8-like 1 0.921135
BCAP29 B-cell receptor-associated protein 29 0.921135
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.921135
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.921135
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.921135
TEX12 testis expressed 12 0.921135
RNF26 ring finger protein 26 0.921135
RNF20 ring finger protein 20, E3 ubiquitin protein ligase 0.921135
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 0.921135
RFWD3 ring finger and WD repeat domain 3 0.921135
CIAO1 cytosolic iron-sulfur assembly component 1 0.921135
FMN2 formin 2 0.921135
TMEM19 transmembrane protein 19 0.921135
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.921135
CLDN12 claudin 12 0.921135
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 0.921135
GCOM1 GRINL1A complex locus 1 0.921135
MAP3K7CL MAP3K7 C-terminal like 0.921135
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.921135
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 0.921135
PPP1R16B protein phosphatase 1, regulatory subunit 16B 0.921135
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 0.921135
NCAM1 neural cell adhesion molecule 1 0.921135
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative) 0.880544
ANXA8 annexin A8 0.880544
ZNF225 zinc finger protein 225 0.880544
RERG RAS-like, estrogen-regulated, growth inhibitor 0.880544
RBM22 RNA binding motif protein 22 0.880544
ZNF20 zinc finger protein 20 0.880544
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.880544
ZNF562 zinc finger protein 562 0.880544
PPP1R3D protein phosphatase 1, regulatory subunit 3D 0.880544
POLG polymerase (DNA directed), gamma 0.880544
GEMIN8 gem (nuclear organelle) associated protein 8 0.880544
MTRNR2L8 MT-RNR2-like 8 0.880544
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 0.880544
RBM41 RNA binding motif protein 41 0.880544
HRASLS5 HRAS-like suppressor family, member 5 0.880544
RHPN2 rhophilin, Rho GTPase binding protein 2 0.880544
ZBTB14 zinc finger and BTB domain containing 14 0.880544
CLIC6 chloride intracellular channel 6 0.880544
ARL2BP ADP-ribosylation factor-like 2 binding protein 0.880544
GPD1L glycerol-3-phosphate dehydrogenase 1-like 0.880544
SSTR1 somatostatin receptor 1 0.880544
SLC30A5 solute carrier family 30 (zinc transporter), member 5 0.880544
CPT1A carnitine palmitoyltransferase 1A (liver) 0.880544
ANAPC1 anaphase promoting complex subunit 1 0.843347
TSPYL6 TSPY-like 6 0.843347
KRIT1 KRIT1, ankyrin repeat containing 0.843347
GSAP gamma-secretase activating protein 0.843347
PHTF2 putative homeodomain transcription factor 2 0.843347
SHOX short stature homeobox 0.843347
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.843347
ARHGAP11A Rho GTPase activating protein 11A 0.843347
ZNF548 zinc finger protein 548 0.843347
SLC30A4 solute carrier family 30 (zinc transporter), member 4 0.843347
MSL2 male-specific lethal 2 homolog (Drosophila) 0.843347
PLAG1 pleiomorphic adenoma gene 1 0.843347
CTGF connective tissue growth factor 0.843347
RIOK3 RIO kinase 3 0.843347
TMEM47 transmembrane protein 47 0.843347
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.843347
SYNJ2BP-COX16 SYNJ2BP-COX16 readthrough 0.843347
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.843347
TECRL trans-2,3-enoyl-CoA reductase-like 0.843347
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.843347
RBM33 RNA binding motif protein 33 0.843347
SLCO5A1 solute carrier organic anion transporter family, member 5A1 0.843347
CLIP3 CAP-GLY domain containing linker protein 3 0.843347
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.843347
ARMS2 age-related maculopathy susceptibility 2 0.843347
ZCCHC16 zinc finger, CCHC domain containing 16 0.843347
POMP proteasome maturation protein 0.843347
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.843347
CNOT7 CCR4-NOT transcription complex, subunit 7 0.843347
GSE1 Gse1 coiled-coil protein 0.843347
APOL6 apolipoprotein L, 6 0.809003
JADE2 jade family PHD finger 2 0.809003
C1ORF141 chromosome 1 open reading frame 141 0.809003
RSBN1 round spermatid basic protein 1 0.809003
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.809003
COL1A2 collagen, type I, alpha 2 0.809003
PRKCI protein kinase C, iota 0.809003
RSAD2 radical S-adenosyl methionine domain containing 2 0.809003
MYO5A myosin VA (heavy chain 12, myoxin) 0.809003
ZNF254 zinc finger protein 254 0.809003
SPIN2A spindlin family, member 2A 0.809003
LMAN1 lectin, mannose-binding, 1 0.809003
LEMD2 LEM domain containing 2 0.809003
POTEC POTE ankyrin domain family, member C 0.809003
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 0.809003
OBSL1 obscurin-like 1 0.809003
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.809003
INTS6 integrator complex subunit 6 0.809003
CCDC121 coiled-coil domain containing 121 0.809003
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.809003
LOC253044 0.809003
KCTD10 potassium channel tetramerization domain containing 10 0.809003
ZNF322 zinc finger protein 322 0.809003
CCDC43 coiled-coil domain containing 43 0.809003
SIM2 single-minded family bHLH transcription factor 2 0.809003
SPATA13 spermatogenesis associated 13 0.809003
IL2RA interleukin 2 receptor, alpha 0.809003
SPIN2B spindlin family, member 2B 0.809003