hycanthone-1614 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the hycanthone-1614 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ASIC1 acid sensing (proton gated) ion channel 1
ATR ATR serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAG5 BCL2-associated athanogene 5
BLVRA biliverdin reductase A
BMP2K BMP2 inducible kinase
BRCA2 breast cancer 2, early onset
C5ORF30 chromosome 5 open reading frame 30
CAPN10 calpain 10
CASP6 caspase 6, apoptosis-related cysteine peptidase
CBX5 chromobox homolog 5
CCHCR1 coiled-coil alpha-helical rod protein 1
CCNE2 cyclin E2
CDK1 cyclin-dependent kinase 1
CHEK1 checkpoint kinase 1
CIZ1 CDKN1A interacting zinc finger protein 1
CKB creatine kinase, brain
CS citrate synthase
DBF4 DBF4 zinc finger
DBN1 drebrin 1
DGCR8 DGCR8 microprocessor complex subunit
DHFR dihydrofolate reductase
DXO decapping exoribonuclease
E2F1 E2F transcription factor 1
FANCA Fanconi anemia, complementation group A
FBXO21 F-box protein 21
FBXO9 F-box protein 9
FLOT1 flotillin 1
FTSJ2 FtsJ RNA methyltransferase homolog 2 (E. coli)
FZD2 frizzled class receptor 2
GEMIN4 gem (nuclear organelle) associated protein 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
HELLS helicase, lymphoid-specific
HEXIM1 hexamethylene bis-acetamide inducible 1
IER3 immediate early response 3
IL1RN interleukin 1 receptor antagonist
IMPAD1 inositol monophosphatase domain containing 1
JUN jun proto-oncogene
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KDM5A lysine (K)-specific demethylase 5A
KLF10 Kruppel-like factor 10
KPNA1 karyopherin alpha 1 (importin alpha 5)
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LDAH lipid droplet associated hydrolase
LRRC37A2 leucine rich repeat containing 37, member A2
LTB lymphotoxin beta (TNF superfamily, member 3)
MICALL1 MICAL-like 1
MRPL19 mitochondrial ribosomal protein L19
MTRF1L mitochondrial translational release factor 1-like
MYL10 myosin, light chain 10, regulatory
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit
NBPF10 neuroblastoma breakpoint family, member 10
NDRG2 NDRG family member 2
NINJ1 ninjurin 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
ORC4 origin recognition complex, subunit 4
PCGF2 polycomb group ring finger 2
PDGFA platelet-derived growth factor alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PRELP proline/arginine-rich end leucine-rich repeat protein
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTMA prothymosin, alpha
PTX3 pentraxin 3, long
RABL6 RAB, member RAS oncogene family-like 6
RBL2 retinoblastoma-like 2
RECQL4 RecQ protein-like 4
RSAD1 radical S-adenosyl methionine domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SEC23B Sec23 homolog B (S. cerevisiae)
SIDT2 SID1 transmembrane family, member 2
SMAD7 SMAD family member 7
SNX11 sorting nexin 11
SOS1 son of sevenless homolog 1 (Drosophila)
SPATS2 spermatogenesis associated, serine-rich 2
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
THTPA thiamine triphosphatase
TMPRSS15 transmembrane protease, serine 15
TOB1 transducer of ERBB2, 1
TPM1 tropomyosin 1 (alpha)
TRAIP TRAF interacting protein
TSPYL2 TSPY-like 2
TST thiosulfate sulfurtransferase (rhodanese)
TUBB3 tubulin, beta 3 class III
UBQLN4 ubiquilin 4
UNC119B unc-119 homolog B (C. elegans)
WASF1 WAS protein family, member 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF142 zinc finger protein 142
ZNF250 zinc finger protein 250

decreased expression

Symbol Name
ARHGAP10 Rho GTPase activating protein 10
ARHGAP15 Rho GTPase activating protein 15
ATAD2B ATPase family, AAA domain containing 2B
ATP8B4 ATPase, class I, type 8B, member 4
BAK1 BCL2-antagonist/killer 1
C4ORF29 chromosome 4 open reading frame 29
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CASZ1 castor zinc finger 1
CD82 CD82 molecule
CER1 cerberus 1, DAN family BMP antagonist
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CIR1 corepressor interacting with RBPJ, 1
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CLTCL1 clathrin, heavy chain-like 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSG cathepsin G
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DOK2 docking protein 2, 56kDa
DPYD dihydropyrimidine dehydrogenase
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
ELMO1 engulfment and cell motility 1
ERO1L ERO1-like (S. cerevisiae)
FAM53B family with sequence similarity 53, member B
FBXW4 F-box and WD repeat domain containing 4
FMO4 flavin containing monooxygenase 4
FOCAD focadhesin
FTO fat mass and obesity associated
GBP2 guanylate binding protein 2, interferon-inducible
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
HJURP Holliday junction recognition protein
HMGB3P1 high mobility group box 3 pseudogene 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCTD20 potassium channel tetramerization domain containing 20
KIAA0556 KIAA0556
KIF13B kinesin family member 13B
KLHL12 kelch-like family member 12
LOC642236 FSHD region gene 1 pseudogene
LPAR6 lysophosphatidic acid receptor 6
LRRC8D leucine rich repeat containing 8 family, member D
MGAM maltase-glucoamylase
MITF microphthalmia-associated transcription factor
MRGBP MRG/MORF4L binding protein
MX1 MX dynamin-like GTPase 1
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NAT10 N-acetyltransferase 10 (GCN5-related)
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
NUP93 nucleoporin 93kDa
OR2C1 olfactory receptor, family 2, subfamily C, member 1
ORC1 origin recognition complex, subunit 1
ORM1 orosomucoid 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAK1IP1 PAK1 interacting protein 1
PANK4 pantothenate kinase 4
PARN poly(A)-specific ribonuclease
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PNPLA6 patatin-like phospholipase domain containing 6
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PSAT1 phosphoserine aminotransferase 1
PSKH1 protein serine kinase H1
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB4B RAB4B, member RAS oncogene family
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RBM15B RNA binding motif protein 15B
RBM28 RNA binding motif protein 28
RFTN1 raftlin, lipid raft linker 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SAMHD1 SAM domain and HD domain 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAC SH3 and cysteine rich domain
STAG1 stromal antigen 1
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TCTN2 tectonic family member 2
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
WDR70 WD repeat domain 70
ZNF282 zinc finger protein 282
ZNF721 zinc finger protein 721