hycanthone Gene Set

Dataset	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category	transcriptomics
Type	small molecule perturbation
Description	A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel. (Chemical Entities of Biological Interest Ontology, CHEBI_52768)
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Genes

15 genes differentially expressed following the hycanthone small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol	Name	Standardized Value
UBE2A	ubiquitin-conjugating enzyme E2A	3.69371
C1ORF105	chromosome 1 open reading frame 105	3.26112
CHRNA2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	3.1044
TTC22	tetratricopeptide repeat domain 22	3.03909

decreased expression

Symbol	Name	Standardized Value
HMG20B	high mobility group 20B	-5.20779
PLK1	polo-like kinase 1	-3.73202
QSER1	glutamine and serine rich 1	-3.64044
KIF18A	kinesin family member 18A	-3.37827
ARHGAP11A	Rho GTPase activating protein 11A	-3.33213
SPC25	SPC25, NDC80 kinetochore complex component	-3.16948
DNAJC24	DnaJ (Hsp40) homolog, subfamily C, member 24	-3.15592
UBE2C	ubiquitin-conjugating enzyme E2C	-3.14725
ALKBH4	alkB, alkylation repair homolog 4 (E. coli)	-3.06847
PARP2	poly (ADP-ribose) polymerase 2	-3.06517
SLC25A21	solute carrier family 25 (mitochondrial oxoadipate carrier), member 21	-3.01697