hydralazine-2311 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the hydralazine-2311 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ADAM22 ADAM metallopeptidase domain 22
AHNAK2 AHNAK nucleoprotein 2
ALDOB aldolase B, fructose-bisphosphate
APOL6 apolipoprotein L, 6
AQP7 aquaporin 7
ARG1 arginase 1
ARSD arylsulfatase D
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C17ORF59 chromosome 17 open reading frame 59
C1ORF61 chromosome 1 open reading frame 61
C3AR1 complement component 3a receptor 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC69 coiled-coil domain containing 69
CD8A CD8a molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CPA1 carboxypeptidase A1 (pancreatic)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DICER1 dicer 1, ribonuclease type III
DMPK dystrophia myotonica-protein kinase
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DNALI1 dynein, axonemal, light intermediate chain 1
DRICH1 aspartate-rich 1
ECM1 extracellular matrix protein 1
ERCC2 excision repair cross-complementation group 2
FAS Fas cell surface death receptor
FGD1 FYVE, RhoGEF and PH domain containing 1
FHL1 four and a half LIM domains 1
FRMD1 FERM domain containing 1
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GGT1 gamma-glutamyltransferase 1
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRIA4 glutamate receptor, ionotropic, AMPA 4
HFE hemochromatosis
HOXA7 homeobox A7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDS iduronate 2-sulfatase
IGLJ3 immunoglobulin lambda joining 3
IMPG2 interphotoreceptor matrix proteoglycan 2
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KITLG KIT ligand
LOXL3 lysyl oxidase-like 3
LRRC40 leucine rich repeat containing 40
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LUZP4 leucine zipper protein 4
LZTS3 leucine zipper, putative tumor suppressor family member 3
MX1 MX dynamin-like GTPase 1
NDN necdin, melanoma antigen (MAGE) family member
NDNF neuron-derived neurotrophic factor
NEUROD4 neuronal differentiation 4
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPR3 natriuretic peptide receptor 3
OLFM1 olfactomedin 1
PCDH1 protocadherin 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDCD2 programmed cell death 2
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB2 phospholipase C, beta 2
PPARA peroxisome proliferator-activated receptor alpha
PRB4 proline-rich protein BstNI subfamily 4
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PTCH1 patched 1
PTK2B protein tyrosine kinase 2 beta
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RETN resistin
RHBDD3 rhomboid domain containing 3
RORC RAR-related orphan receptor C
RPS3A ribosomal protein S3A
SCAND2P SCAN domain containing 2 pseudogene
SELL selectin L
SHANK1 SH3 and multiple ankyrin repeat domains 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SOS2 son of sevenless homolog 2 (Drosophila)
SOX21 SRY (sex determining region Y)-box 21
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPRY2 sprouty homolog 2 (Drosophila)
STAC SH3 and cysteine rich domain
STAT2 signal transducer and activator of transcription 2, 113kDa
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBL1Y transducin (beta)-like 1, Y-linked
TRIM29 tripartite motif containing 29
VAV2 vav 2 guanine nucleotide exchange factor
VCX2 variable charge, X-linked 2
VNN2 vanin 2
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WNT16 wingless-type MMTV integration site family, member 16
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
AHCTF1 AT hook containing transcription factor 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATAD5 ATPase family, AAA domain containing 5
ATP13A2 ATPase type 13A2
AZI2 5-azacytidine induced 2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
C11ORF30 chromosome 11 open reading frame 30
C1ORF105 chromosome 1 open reading frame 105
CA5BP1 carbonic anhydrase VB pseudogene 1
CASZ1 castor zinc finger 1
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CCP110 centriolar coiled coil protein 110kDa
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEP85 centrosomal protein 85kDa
CGREF1 cell growth regulator with EF-hand domain 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EPHX2 epoxide hydrolase 2, cytoplasmic
FAM114A2 family with sequence similarity 114, member A2
FAM131A family with sequence similarity 131, member A
FBXO2 F-box protein 2
FGF23 fibroblast growth factor 23
FLCN folliculin
GALK1 galactokinase 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR21 G protein-coupled receptor 21
GSTM5 glutathione S-transferase mu 5
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
HMG20A high mobility group 20A
IFT140 intraflagellar transport 140
IFT81 intraflagellar transport 81
IQSEC2 IQ motif and Sec7 domain 2
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEL Kell blood group, metallo-endopeptidase
KIAA0125 KIAA0125
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC390998 ribosomal protein L10 pseudogene
LPXN leupaxin
LRP5L low density lipoprotein receptor-related protein 5-like
LYPLA2P1 lysophospholipase II pseudogene 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEB2 melanoma antigen family B2
MAP6D1 MAP6 domain containing 1
MAST3 microtubule associated serine/threonine kinase 3
MCOLN3 mucolipin 3
MMP2 matrix metallopeptidase 2
MUC3A mucin 3A, cell surface associated
MYO1E myosin IE
NLRX1 NLR family member X1
NPFFR1 neuropeptide FF receptor 1
NPIPB15 nuclear pore complex interacting protein family, member B15
OSMR oncostatin M receptor
PALM paralemmin
PC pyruvate carboxylase
PCDHB3 protocadherin beta 3
PCDHB8 protocadherin beta 8
PER3 period circadian clock 3
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
RAB27B RAB27B, member RAS oncogene family
RNF19B ring finger protein 19B
SCAI suppressor of cancer cell invasion
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SIRT2 sirtuin 2
SIRT6 sirtuin 6
SIX1 SIX homeobox 1
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SNX16 sorting nexin 16
SRD5A3 steroid 5 alpha-reductase 3
STIM1 stromal interaction molecule 1
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCP10 t-complex 10
TMEM104 transmembrane protein 104
TMEM121 transmembrane protein 121
TRIM68 tripartite motif containing 68
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUBA3C tubulin, alpha 3c
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
VASP vasodilator-stimulated phosphoprotein
WASF1 WAS protein family, member 1
WDR7 WD repeat domain 7
ZBTB48 zinc finger and BTB domain containing 48
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF16 zinc finger protein 16
ZNF282 zinc finger protein 282
ZNF324 zinc finger protein 324
ZNF350 zinc finger protein 350
ZNF428 zinc finger protein 428
ZNF468 zinc finger protein 468
ZNF862 zinc finger protein 862