hydralazine-2349 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the hydralazine-2349 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ARRB1 arrestin, beta 1
BMP7 bone morphogenetic protein 7
BMP8B bone morphogenetic protein 8b
C16ORF58 chromosome 16 open reading frame 58
C5ORF45 chromosome 5 open reading frame 45
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCPG1 cell cycle progression 1
CD59 CD59 molecule, complement regulatory protein
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK13 cyclin-dependent kinase 13
CDK16 cyclin-dependent kinase 16
CHPF chondroitin polymerizing factor
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COPE coatomer protein complex, subunit epsilon
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DCAF15 DDB1 and CUL4 associated factor 15
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAL4 dynein, axonemal, light chain 4
DPY19L1 dpy-19-like 1 (C. elegans)
DSTYK dual serine/threonine and tyrosine protein kinase
DTNA dystrobrevin, alpha
E2F4 E2F transcription factor 4, p107/p130-binding
ELK1 ELK1, member of ETS oncogene family
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM3A family with sequence similarity 3, member A
GAL galanin/GMAP prepropeptide
GEMIN4 gem (nuclear organelle) associated protein 4
GID4 GID complex subunit 4
GJB1 gap junction protein, beta 1, 32kDa
GNS glucosamine (N-acetyl)-6-sulfatase
GPR153 G protein-coupled receptor 153
HBB hemoglobin, beta
HIST1H1T histone cluster 1, H1t
HIST1H2BN histone cluster 1, H2bn
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HN1L hematological and neurological expressed 1-like
ICAM2 intercellular adhesion molecule 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
KDM4C lysine (K)-specific demethylase 4C
KDM5A lysine (K)-specific demethylase 5A
KIAA0753 KIAA0753
KMT2A lysine (K)-specific methyltransferase 2A
LINC00597 long intergenic non-protein coding RNA 597
LTB lymphotoxin beta (TNF superfamily, member 3)
MTCP1 mature T-cell proliferation 1
MXD3 MAX dimerization protein 3
NCALD neurocalcin delta
NF1 neurofibromin 1
NLE1 notchless homolog 1 (Drosophila)
NOTCH2 notch 2
NUAK1 NUAK family, SNF1-like kinase, 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PDE4DIP phosphodiesterase 4D interacting protein
PIAS3 protein inhibitor of activated STAT, 3
PLCD1 phospholipase C, delta 1
PLIN2 perilipin 2
PLSCR3 phospholipid scramblase 3
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRLH prolactin releasing hormone
PRMT2 protein arginine methyltransferase 2
PSD3 pleckstrin and Sec7 domain containing 3
PSG4 pregnancy specific beta-1-glycoprotein 4
PTH2R parathyroid hormone 2 receptor
RALGDS ral guanine nucleotide dissociation stimulator
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGS12 regulator of G-protein signaling 12
RPAP1 RNA polymerase II associated protein 1
RUFY3 RUN and FYVE domain containing 3
SGSM2 small G protein signaling modulator 2
SIDT2 SID1 transmembrane family, member 2
SMG7 SMG7 nonsense mediated mRNA decay factor
SOCS2 suppressor of cytokine signaling 2
STBD1 starch binding domain 1
STC2 stanniocalcin 2
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TMCO3 transmembrane and coiled-coil domains 3
TMEM53 transmembrane protein 53
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TP53I11 tumor protein p53 inducible protein 11
TPMT thiopurine S-methyltransferase
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
USB1 U6 snRNA biogenesis 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR60 WD repeat domain 60
ZBTB22 zinc finger and BTB domain containing 22
ZFX zinc finger protein, X-linked
ZNF287 zinc finger protein 287
ZNF500 zinc finger protein 500
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACAD10 acyl-CoA dehydrogenase family, member 10
ADAP2 ArfGAP with dual PH domains 2
AGO4 argonaute RISC catalytic component 4
ALDOC aldolase C, fructose-bisphosphate
APH1B APH1B gamma secretase subunit
ATG9A autophagy related 9A
AVPI1 arginine vasopressin-induced 1
BAG4 BCL2-associated athanogene 4
BAHCC1 BAH domain and coiled-coil containing 1
BTF3P12 basic transcription factor 3 pseudogene 12
C16ORF59 chromosome 16 open reading frame 59
C7ORF69 chromosome 7 open reading frame 69
CARD9 caspase recruitment domain family, member 9
CCDC109B coiled-coil domain containing 109B
CDA cytidine deaminase
CDC23 cell division cycle 23
CENPB centromere protein B, 80kDa
CEP85 centrosomal protein 85kDa
CIC capicua transcriptional repressor
CIR1 corepressor interacting with RBPJ, 1
CYSLTR1 cysteinyl leukotriene receptor 1
ECSIT ECSIT signalling integrator
EDAR ectodysplasin A receptor
ELAC1 elaC ribonuclease Z 1
EXD2 exonuclease 3'-5' domain containing 2
F3 coagulation factor III (thromboplastin, tissue factor)
FJX1 four jointed box 1 (Drosophila)
FLJ21369 uncharacterized protein FLJ21369
GMPPA GDP-mannose pyrophosphorylase A
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPATCH2 G patch domain containing 2
GPR183 G protein-coupled receptor 183
IRF7 interferon regulatory factor 7
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIF18A kinesin family member 18A
LOC729164 hCG1732469
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP6D1 MAP6 domain containing 1
METTL21B methyltransferase like 21B
MPZ myelin protein zero
MTMR11 myotubularin related protein 11
MYL5 myosin, light chain 5, regulatory
NARFL nuclear prelamin A recognition factor-like
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NLRX1 NLR family member X1
NPFFR1 neuropeptide FF receptor 1
NRGN neurogranin (protein kinase C substrate, RC3)
NTSR1 neurotensin receptor 1 (high affinity)
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PBX3 pre-B-cell leukemia homeobox 3
PCYOX1 prenylcysteine oxidase 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
POLH polymerase (DNA directed), eta
PRAF2 PRA1 domain family, member 2
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PWAR5 Prader Willi/Angelman region RNA 5
RAB8B RAB8B, member RAS oncogene family
RBBP5 retinoblastoma binding protein 5
RBM47 RNA binding motif protein 47
RNF121 ring finger protein 121
RPA4 replication protein A4, 30kDa
SETD1A SET domain containing 1A
SKI SKI proto-oncogene
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SMR3A submaxillary gland androgen regulated protein 3A
SNRPN small nuclear ribonucleoprotein polypeptide N
SPATA2L spermatogenesis associated 2-like
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAG3 stromal antigen 3
SUN2 Sad1 and UNC84 domain containing 2
TBXAS1 thromboxane A synthase 1 (platelet)
TIGD6 tigger transposable element derived 6
TM7SF2 transmembrane 7 superfamily member 2
TMC7 transmembrane channel-like 7
TMEM185B transmembrane protein 185B
TMEM212 transmembrane protein 212
TMEM254 transmembrane protein 254
TMOD3 tropomodulin 3 (ubiquitous)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM22 tripartite motif containing 22
TUBGCP5 tubulin, gamma complex associated protein 5
URGCP upregulator of cell proliferation
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR62 WD repeat domain 62
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB48 zinc finger and BTB domain containing 48
ZMYM3 zinc finger, MYM-type 3
ZNF16 zinc finger protein 16
ZNF280D zinc finger protein 280D
ZNF669 zinc finger protein 669
ZNF701 zinc finger protein 701
ZSCAN16 zinc finger and SCAN domain containing 16
ZSCAN31 zinc finger and SCAN domain containing 31