hydralazine-3621 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the hydralazine-3621 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFF2 AF4/FMR2 family, member 2
ALOX12 arachidonate 12-lipoxygenase
ANGPTL2 angiopoietin-like 2
AQP2 aquaporin 2 (collecting duct)
ATF5 activating transcription factor 5
ATN1 atrophin 1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C10ORF95 chromosome 10 open reading frame 95
C1S complement component 1, s subcomponent
CALML3 calmodulin-like 3
CCDC64 coiled-coil domain containing 64
CD101 CD101 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDHR2 cadherin-related family member 2
CDK14 cyclin-dependent kinase 14
CLCF1 cardiotrophin-like cytokine factor 1
COL3A1 collagen, type III, alpha 1
COL7A1 collagen, type VII, alpha 1
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CXCL9 chemokine (C-X-C motif) ligand 9
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DGCR2 DiGeorge syndrome critical region gene 2
DKFZP434C153 DKFZP434C153 protein
EDN1 endothelin 1
EFNB3 ephrin-B3
EPPIN epididymal peptidase inhibitor
FAM153A family with sequence similarity 153, member A
FAM182B family with sequence similarity 182, member B
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GEMIN7 gem (nuclear organelle) associated protein 7
GLIPR1 GLI pathogenesis-related 1
GNRH2 gonadotropin-releasing hormone 2
GPM6A glycoprotein M6A
HLA-G major histocompatibility complex, class I, G
HR hair growth associated
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IFI44 interferon-induced protein 44
ING2 inhibitor of growth family, member 2
KRT17 keratin 17, type I
KXD1 KxDL motif containing 1
LINC00597 long intergenic non-protein coding RNA 597
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAGOH2P mago-nashi homolog 2, pseudogene
MALL mal, T-cell differentiation protein-like
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MARS methionyl-tRNA synthetase
MTMR8 myotubularin related protein 8
MVB12B multivesicular body subunit 12B
NPC1 Niemann-Pick disease, type C1
NPR2 natriuretic peptide receptor 2
NPTX1 neuronal pentraxin I
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OTOR otoraplin
PCDHGA10 protocadherin gamma subfamily A, 10
PDLIM3 PDZ and LIM domain 3
PDLIM7 PDZ and LIM domain 7 (enigma)
PKD2L2 polycystic kidney disease 2-like 2
PKNOX2 PBX/knotted 1 homeobox 2
PLAC4 placenta-specific 4
PML promyelocytic leukemia
RASA3 RAS p21 protein activator 3
RHAG Rh-associated glycoprotein
RIMS3 regulating synaptic membrane exocytosis 3
RPL18 ribosomal protein L18
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RYR1 ryanodine receptor 1 (skeletal)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC19A1 solute carrier family 19 (folate transporter), member 1
SP110 SP110 nuclear body protein
SPINK5 serine peptidase inhibitor, Kazal type 5
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SURF1 surfeit 1
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBX3 T-box 3
TEX15 testis expressed 15
THSD4 thrombospondin, type I, domain containing 4
TIMP3 TIMP metallopeptidase inhibitor 3
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRIM48 tripartite motif containing 48
UBA7 ubiquitin-like modifier activating enzyme 7
USP22 ubiquitin specific peptidase 22
ZFPM2 zinc finger protein, FOG family member 2
ZNF639 zinc finger protein 639
ZNF79 zinc finger protein 79
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
AHSP alpha hemoglobin stabilizing protein
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BCO1 beta-carotene oxygenase 1
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BIRC7 baculoviral IAP repeat containing 7
C11ORF21 chromosome 11 open reading frame 21
C11ORF30 chromosome 11 open reading frame 30
C1ORF159 chromosome 1 open reading frame 159
C2ORF27A chromosome 2 open reading frame 27A
C9ORF9 chromosome 9 open reading frame 9
CD3D CD3d molecule, delta (CD3-TCR complex)
CD53 CD53 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CLCN5 chloride channel, voltage-sensitive 5
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPNE7 copine VII
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CXXC4 CXXC finger protein 4
DOK2 docking protein 2, 56kDa
DOK5 docking protein 5
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPN1 epsin 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV7 ets variant 7
FAM212B family with sequence similarity 212, member B
FBXO31 F-box protein 31
FRS2 fibroblast growth factor receptor substrate 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GBP2 guanylate binding protein 2, interferon-inducible
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPR27 G protein-coupled receptor 27
HIST1H1D histone cluster 1, H1d
HOXD11 homeobox D11
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HYAL1 hyaluronoglucosaminidase 1
IFT140 intraflagellar transport 140
IL17RA interleukin 17 receptor A
IRF1 interferon regulatory factor 1
KAT2A K(lysine) acetyltransferase 2A
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNK5 potassium channel, two pore domain subfamily K, member 5
KDM7A lysine (K)-specific demethylase 7A
KPNA5 karyopherin alpha 5 (importin alpha 6)
LHX6 LIM homeobox 6
LIF leukemia inhibitory factor
LIME1 Lck interacting transmembrane adaptor 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MCOLN3 mucolipin 3
MDM4 MDM4, p53 regulator
MEFV Mediterranean fever
MFAP2 microfibrillar-associated protein 2
NDE1 nudE neurodevelopment protein 1
NLRX1 NLR family member X1
NPTX2 neuronal pentraxin II
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OLFML2A olfactomedin-like 2A
ONECUT2 one cut homeobox 2
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OXTR oxytocin receptor
PGLYRP4 peptidoglycan recognition protein 4
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
REM1 RAS (RAD and GEM)-like GTP-binding 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMIM14 small integral membrane protein 14
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SSTR4 somatostatin receptor 4
TARP TCR gamma alternate reading frame protein
TBKBP1 TBK1 binding protein 1
TCTN1 tectonic family member 1
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TRIM25 tripartite motif containing 25
TSC22D4 TSC22 domain family, member 4
UNC119 unc-119 homolog (C. elegans)
VASH2 vasohibin 2
VAX2 ventral anterior homeobox 2
VGF VGF nerve growth factor inducible
VIPR1 vasoactive intestinal peptide receptor 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZBTB48 zinc finger and BTB domain containing 48
ZNF205 zinc finger protein 205
ZNF329 zinc finger protein 329
ZNF532 zinc finger protein 532
ZSCAN2 zinc finger and SCAN domain containing 2