hydralazine-4282 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the hydralazine-4282 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
AADAC arylacetamide deacetylase
ABHD17B abhydrolase domain containing 17B
ADAP1 ArfGAP with dual PH domains 1
ADGRF5 adhesion G protein-coupled receptor F5
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKRD55 ankyrin repeat domain 55
BMP5 bone morphogenetic protein 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA1 carbonic anhydrase I
CAMK1D calcium/calmodulin-dependent protein kinase ID
CD22 CD22 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDHR2 cadherin-related family member 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CNTFR ciliary neurotrophic factor receptor
COL9A3 collagen, type IX, alpha 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPEB3 cytoplasmic polyadenylation element binding protein 3
CRYGC crystallin, gamma C
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
CYTH3 cytohesin 3
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DHRS12 dehydrogenase/reductase (SDR family) member 12
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DSG3 desmoglein 3
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EDRF1 erythroid differentiation regulatory factor 1
EML2 echinoderm microtubule associated protein like 2
FOLR2 folate receptor 2 (fetal)
FOSL2 FOS-like antigen 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GATA3 GATA binding protein 3
GIMAP6 GTPase, IMAP family member 6
GPR17 G protein-coupled receptor 17
GRK5 G protein-coupled receptor kinase 5
GRM1 glutamate receptor, metabotropic 1
HIST1H2AK histone cluster 1, H2ak
HOMER3 homer scaffolding protein 3
HR hair growth associated
HRH3 histamine receptor H3
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
IRF4 interferon regulatory factor 4
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KLHL22 kelch-like family member 22
KRT86 keratin 86, type II
LAT2 linker for activation of T cells family, member 2
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LOC100294391 uncharacterized LOC100294391
LOXL3 lysyl oxidase-like 3
MAGOH2P mago-nashi homolog 2, pseudogene
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MCF2L MCF.2 cell line derived transforming sequence-like
MEF2D myocyte enhancer factor 2D
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MORC1 MORC family CW-type zinc finger 1
MRPL41 mitochondrial ribosomal protein L41
MUC3A mucin 3A, cell surface associated
MVB12B multivesicular body subunit 12B
N4BP1 NEDD4 binding protein 1
NCLN nicalin
NCOR2 nuclear receptor corepressor 2
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NIPAL2 NIPA-like domain containing 2
NOVA2 neuro-oncological ventral antigen 2
NPR1 natriuretic peptide receptor 1
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
PDPN podoplanin
PECAM1 platelet/endothelial cell adhesion molecule 1
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein
PKP3 plakophilin 3
POU3F1 POU class 3 homeobox 1
PRUNE2 prune homolog 2 (Drosophila)
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RBMS2 RNA binding motif, single stranded interacting protein 2
RGS14 regulator of G-protein signaling 14
RIBC2 RIB43A domain with coiled-coils 2
RXRB retinoid X receptor, beta
SAYSD1 SAYSVFN motif domain containing 1
SCNN1B sodium channel, non voltage gated 1 beta subunit
SELPLG selectin P ligand
SLC22A14 solute carrier family 22, member 14
SMO smoothened, frizzled class receptor
SUGP1 SURP and G patch domain containing 1
SYMPK symplekin
TET3 tet methylcytosine dioxygenase 3
THBS1 thrombospondin 1
TK2 thymidine kinase 2, mitochondrial
TLDC1 TBC/LysM-associated domain containing 1
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VCAN versican
VCL vinculin
WNT3 wingless-type MMTV integration site family, member 3
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZIM2 zinc finger, imprinted 2
ZNF343 zinc finger protein 343
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
ANKH ANKH inorganic pyrophosphate transport regulator
ANKRD36 ankyrin repeat domain 36
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
C17ORF53 chromosome 17 open reading frame 53
C5ORF42 chromosome 5 open reading frame 42
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CD82 CD82 molecule
CENPJ centromere protein J
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CIR1 corepressor interacting with RBPJ, 1
CLEC4E C-type lectin domain family 4, member E
COL21A1 collagen, type XXI, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY2 cryptochrome circadian clock 2
DEPDC1 DEP domain containing 1
EDIL3 EGF-like repeats and discoidin I-like domains 3
EGR2 early growth response 2
ELP6 elongator acetyltransferase complex subunit 6
ETV6 ets variant 6
FAM186A family with sequence similarity 186, member A
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FOXN2 forkhead box N2
FRS3 fibroblast growth factor receptor substrate 3
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRM6 glutamate receptor, metabotropic 6
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H2AJ histone cluster 1, H2aj
HIST1H4C histone cluster 1, H4c
HIST1H4D histone cluster 1, H4d
HOXC5 homeobox C5
IDI2-AS1 IDI2 antisense RNA 1
IFI6 interferon, alpha-inducible protein 6
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL24 interleukin 24
IL6 interleukin 6
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC390998 ribosomal protein L10 pseudogene
MBIP MAP3K12 binding inhibitory protein 1
MED18 mediator complex subunit 18
MED31 mediator complex subunit 31
METTL2B methyltransferase like 2B
MIS18BP1 MIS18 binding protein 1
MMP3 matrix metallopeptidase 3
MTA2 metastasis associated 1 family, member 2
MXD3 MAX dimerization protein 3
NABP1 nucleic acid binding protein 1
NEK11 NIMA-related kinase 11
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NOL10 nucleolar protein 10
NXPH4 neurexophilin 4
PACS1 phosphofurin acidic cluster sorting protein 1
PCOLCE procollagen C-endopeptidase enhancer
PDE12 phosphodiesterase 12
PID1 phosphotyrosine interaction domain containing 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POLL polymerase (DNA directed), lambda
PPT2 palmitoyl-protein thioesterase 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFX7 regulatory factor X, 7
RNF122 ring finger protein 122
RPS14P3 ribosomal protein S14 pseudogene 3
SENP7 SUMO1/sentrin specific peptidase 7
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC46A3 solute carrier family 46, member 3
SLMO1 slowmo homolog 1 (Drosophila)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOX21 SRY (sex determining region Y)-box 21
SP4 Sp4 transcription factor
SPTBN2 spectrin, beta, non-erythrocytic 2
SSBP3 single stranded DNA binding protein 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TCEAL2 transcription elongation factor A (SII)-like 2
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEP1 telomerase-associated protein 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TLN1 talin 1
TRIM21 tripartite motif containing 21
TRPS1 trichorhinophalangeal syndrome I
USP20 ubiquitin specific peptidase 20
VGF VGF nerve growth factor inducible
WDR25 WD repeat domain 25
WFDC2 WAP four-disulfide core domain 2
ZC3H4 zinc finger CCCH-type containing 4
ZNF219 zinc finger protein 219
ZNF639 zinc finger protein 639
ZNF76 zinc finger protein 76
ZNF816 zinc finger protein 816