hydralazine-4746 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the hydralazine-4746 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ADAMDEC1 ADAM-like, decysin 1
AKAP7 A kinase (PRKA) anchor protein 7
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ASCL1 achaete-scute family bHLH transcription factor 1
ATRNL1 attractin-like 1
C1ORF54 chromosome 1 open reading frame 54
C3ORF18 chromosome 3 open reading frame 18
CARD10 caspase recruitment domain family, member 10
CD44 CD44 molecule (Indian blood group)
CD70 CD70 molecule
CLTC clathrin, heavy chain (Hc)
CNR2 cannabinoid receptor 2 (macrophage)
CPED1 cadherin-like and PC-esterase domain containing 1
CST4 cystatin S
CTSE cathepsin E
CTSZ cathepsin Z
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DCLK2 doublecortin-like kinase 2
EVI2B ecotropic viral integration site 2B
FASLG Fas ligand (TNF superfamily, member 6)
FBN2 fibrillin 2
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGB fibrinogen beta chain
FYB FYN binding protein
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GAP43 growth associated protein 43
GAS7 growth arrest-specific 7
GIF gastric intrinsic factor (vitamin B synthesis)
GLS glutaminase
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIP2 glutamate receptor interacting protein 2
HIST1H3I histone cluster 1, H3i
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGN5 high mobility group nucleosome binding domain 5
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXB5 homeobox B5
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IFI6 interferon, alpha-inducible protein 6
INO80D INO80 complex subunit D
INTS1 integrator complex subunit 1
IRAK3 interleukin-1 receptor-associated kinase 3
JAK3 Janus kinase 3
KCNIP1 Kv channel interacting protein 1
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF25-AS1 KIF25 antisense RNA 1
LOC440895 two pore channel 3 pseudogene
LOXL3 lysyl oxidase-like 3
LST1 leukocyte specific transcript 1
MAOA monoamine oxidase A
MAPK10 mitogen-activated protein kinase 10
MAPK7 mitogen-activated protein kinase 7
MBD2 methyl-CpG binding domain protein 2
MEF2C myocyte enhancer factor 2C
MSR1 macrophage scavenger receptor 1
MUC6 mucin 6, oligomeric mucus/gel-forming
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAG18 NAG18 mRNA
NRXN3 neurexin 3
OR1A2 olfactory receptor, family 1, subfamily A, member 2
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PAEP progestagen-associated endometrial protein
PARP8 poly (ADP-ribose) polymerase family, member 8
PHF1 PHD finger protein 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PNMAL1 paraneoplastic Ma antigen family-like 1
POM121 POM121 transmembrane nucleoporin
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTCH2 patched 2
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTN pleiotrophin
RAB40C RAB40C, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RARA retinoic acid receptor, alpha
RBBP4 retinoblastoma binding protein 4
REC8 REC8 meiotic recombination protein
RPH3A rabphilin 3A
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLA Src-like-adaptor
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
TBX21 T-box 21
TCF4 transcription factor 4
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TFEB transcription factor EB
TGFBR3 transforming growth factor, beta receptor III
THRA thyroid hormone receptor, alpha
TTLL5 tubulin tyrosine ligase-like family member 5
WDR78 WD repeat domain 78
WISP3 WNT1 inducible signaling pathway protein 3
WNT16 wingless-type MMTV integration site family, member 16
XYLB xylulokinase homolog (H. influenzae)
YY2 YY2 transcription factor
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ALS2CL ALS2 C-terminal like
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ATAD5 ATPase family, AAA domain containing 5
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AUTS2 autism susceptibility candidate 2
BAX BCL2-associated X protein
C2ORF27A chromosome 2 open reading frame 27A
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CCDC186 coiled-coil domain containing 186
CD82 CD82 molecule
CEP131 centrosomal protein 131kDa
CES3 carboxylesterase 3
CLDN1 claudin 1
CLDN15 claudin 15
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CRYBG3 beta-gamma crystallin domain containing 3
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXADR coxsackie virus and adenovirus receptor
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DOCK4 dedicator of cytokinesis 4
ELP6 elongator acetyltransferase complex subunit 6
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FAM131A family with sequence similarity 131, member A
FBXW12 F-box and WD repeat domain containing 12
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FKBP1B FK506 binding protein 1B, 12.6 kDa
FKBP5 FK506 binding protein 5
FKRP fukutin related protein
GBP2 guanylate binding protein 2, interferon-inducible
GID4 GID complex subunit 4
GMEB1 glucocorticoid modulatory element binding protein 1
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIRA histone cell cycle regulator
HIST1H2AI histone cluster 1, H2ai
HMOX1 heme oxygenase 1
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
IDI2-AS1 IDI2 antisense RNA 1
IL17RA interleukin 17 receptor A
KIAA0125 KIAA0125
KIFC1 kinesin family member C1
LHX6 LIM homeobox 6
LINC00339 long intergenic non-protein coding RNA 339
MCOLN3 mucolipin 3
MDM4 MDM4, p53 regulator
MTA2 metastasis associated 1 family, member 2
MXD3 MAX dimerization protein 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPIPB15 nuclear pore complex interacting protein family, member B15
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5DC3 5'-nucleotidase domain containing 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PDIA3 protein disulfide isomerase family A, member 3
PHEX phosphate regulating endopeptidase homolog, X-linked
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PRPH peripherin
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNF123 ring finger protein 123
RPL23AP32 ribosomal protein L23a pseudogene 32
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
S100A4 S100 calcium binding protein A4
SEC14L2 SEC14-like 2 (S. cerevisiae)
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPRY2 sprouty homolog 2 (Drosophila)
SPRYD7 SPRY domain containing 7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STBD1 starch binding domain 1
STX5 syntaxin 5
TEP1 telomerase-associated protein 1
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TMEM209 transmembrane protein 209
TMEM242 transmembrane protein 242
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TPST2 tyrosylprotein sulfotransferase 2
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM36 tripartite motif containing 36
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSPAN1 tetraspanin 1
UNC93B1 unc-93 homolog B1 (C. elegans)
USB1 U6 snRNA biogenesis 1
WDR76 WD repeat domain 76
ZNF350 zinc finger protein 350
ZNF480 zinc finger protein 480
ZNF669 zinc finger protein 669
ZNF675 zinc finger protein 675
ZSCAN31 zinc finger and SCAN domain containing 31