hydrastinine-1436 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the hydrastinine-1436 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AIF1 allograft inflammatory factor 1
AKAP13 A kinase (PRKA) anchor protein 13
ATAD2B ATPase family, AAA domain containing 2B
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BMP15 bone morphogenetic protein 15
CA5BP1 carbonic anhydrase VB pseudogene 1
CACYBP calcyclin binding protein
CHML choroideremia-like (Rab escort protein 2)
CIITA class II, major histocompatibility complex, transactivator
CLEC1B C-type lectin domain family 1, member B
CNGB3 cyclic nucleotide gated channel beta 3
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CSH2 chorionic somatomammotropin hormone 2
CYB561 cytochrome b561
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DLX2 distal-less homeobox 2
DUS2 dihydrouridine synthase 2
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F4 E2F transcription factor 4, p107/p130-binding
ELMO2 engulfment and cell motility 2
FBXO31 F-box protein 31
FN1 fibronectin 1
G6PC3 glucose 6 phosphatase, catalytic, 3
GAB2 GRB2-associated binding protein 2
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GFOD2 glucose-fructose oxidoreductase domain containing 2
GLS glutaminase
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H4J histone cluster 1, H4j
HMX1 H6 family homeobox 1
ICAM1 intercellular adhesion molecule 1
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IPW imprinted in Prader-Willi syndrome (non-protein coding)
KIAA1109 KIAA1109
KPNA1 karyopherin alpha 1 (importin alpha 5)
KRT2 keratin 2, type II
LAD1 ladinin 1
LDOC1 leucine zipper, down-regulated in cancer 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LOC729164 hCG1732469
LRRN2 leucine rich repeat neuronal 2
MAP7D3 MAP7 domain containing 3
MED18 mediator complex subunit 18
MED31 mediator complex subunit 31
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MVK mevalonate kinase
NAT6 N-acetyltransferase 6 (GCN5-related)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NOTCH1 notch 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OR1F1 olfactory receptor, family 1, subfamily F, member 1
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
OR52A1 olfactory receptor, family 52, subfamily A, member 1
PODNL1 podocan-like 1
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRPF39 pre-mRNA processing factor 39
PRR14L proline rich 14-like
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTMA prothymosin, alpha
RBBP5 retinoblastoma binding protein 5
RNGTT RNA guanylyltransferase and 5'-phosphatase
RNMT RNA (guanine-7-) methyltransferase
RPS11 ribosomal protein S11
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SPG20 spastic paraplegia 20 (Troyer syndrome)
STK19 serine/threonine kinase 19
STX2 syntaxin 2
SYNGR1 synaptogyrin 1
TBC1D4 TBC1 domain family, member 4
TEFM transcription elongation factor, mitochondrial
THBS3 thrombospondin 3
THRB thyroid hormone receptor, beta
TMEM8A transmembrane protein 8A
TMPO thymopoietin
TPR translocated promoter region, nuclear basket protein
TRIB2 tribbles pseudokinase 2
TTC3 tetratricopeptide repeat domain 3
TTLL3 tubulin tyrosine ligase-like family member 3
TUBA4B tubulin, alpha 4b
UMPS uridine monophosphate synthetase
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
YLPM1 YLP motif containing 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZMAT3 zinc finger, matrin-type 3
ZMYND11 zinc finger, MYND-type containing 11

decreased expression

Symbol Name
ACYP2 acylphosphatase 2, muscle type
ANKRD28 ankyrin repeat domain 28
ARHGAP4 Rho GTPase activating protein 4
ASB13 ankyrin repeat and SOCS box containing 13
ASB8 ankyrin repeat and SOCS box containing 8
ATG14 autophagy related 14
AUH AU RNA binding protein/enoyl-CoA hydratase
BCL7B B-cell CLL/lymphoma 7B
BCL7C B-cell CLL/lymphoma 7C
BIN2 bridging integrator 2
BLVRB biliverdin reductase B
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCDC130 coiled-coil domain containing 130
CCDC6 coiled-coil domain containing 6
CCDC94 coiled-coil domain containing 94
CENPT centromere protein T
CFAP74 cilia and flagella associated protein 74
CLDN11 claudin 11
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CORO7 coronin 7
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DCLRE1A DNA cross-link repair 1A
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DERL2 derlin 2
DGAT1 diacylglycerol O-acyltransferase 1
DTX4 deltex 4, E3 ubiquitin ligase
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
E4F1 E4F transcription factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
ERCC2 excision repair cross-complementation group 2
ERCC8 excision repair cross-complementation group 8
FAM188A family with sequence similarity 188, member A
GALR3 galanin receptor 3
GMPPB GDP-mannose pyrophosphorylase B
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HIST1H2BK histone cluster 1, H2bk
HPS6 Hermansky-Pudlak syndrome 6
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HYAL2 hyaluronoglucosaminidase 2
KPTN kaptin (actin binding protein)
LY6E lymphocyte antigen 6 complex, locus E
MACROD1 MACRO domain containing 1
MAGT1 magnesium transporter 1
MAP1S microtubule-associated protein 1S
MED9 mediator complex subunit 9
MON1B MON1 secretory trafficking family member B
MPC1 mitochondrial pyruvate carrier 1
MPST mercaptopyruvate sulfurtransferase
MRPL33 mitochondrial ribosomal protein L33
MXRA8 matrix-remodelling associated 8
NEU1 sialidase 1 (lysosomal sialidase)
NPC2 Niemann-Pick disease, type C2
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
PANK4 pantothenate kinase 4
PAQR4 progestin and adipoQ receptor family member IV
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PEF1 penta-EF-hand domain containing 1
PEX26 peroxisomal biogenesis factor 26
PIEZO1 piezo-type mechanosensitive ion channel component 1
PISD phosphatidylserine decarboxylase
PLA2G12A phospholipase A2, group XIIA
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POMT1 protein-O-mannosyltransferase 1
POR P450 (cytochrome) oxidoreductase
PTX3 pentraxin 3, long
QPRT quinolinate phosphoribosyltransferase
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RNASE6 ribonuclease, RNase A family, k6
RNF187 ring finger protein 187
RP2 retinitis pigmentosa 2 (X-linked recessive)
SH3GL1 SH3-domain GRB2-like 1
SIPA1 signal-induced proliferation-associated 1
SLC2A4RG SLC2A4 regulator
SPATA2L spermatogenesis associated 2-like
SREBF1 sterol regulatory element binding transcription factor 1
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STARD3 StAR-related lipid transfer (START) domain containing 3
STARD5 StAR-related lipid transfer (START) domain containing 5
TAC3 tachykinin 3
TET3 tet methylcytosine dioxygenase 3
TMED1 transmembrane emp24 protein transport domain containing 1
TMEM127 transmembrane protein 127
TPK1 thiamin pyrophosphokinase 1
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBB6 tubulin, beta 6 class V
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UNC93B1 unc-93 homolog B1 (C. elegans)
URM1 ubiquitin related modifier 1
WDR19 WD repeat domain 19
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZNF426 zinc finger protein 426
ZNHIT2 zinc finger, HIT-type containing 2