hydrastinine-2283 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the hydrastinine-2283 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ACPP acid phosphatase, prostate
ADGRF5 adhesion G protein-coupled receptor F5
AGPS alkylglycerone phosphate synthase
AIF1 allograft inflammatory factor 1
ASPN asporin
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3AR1 complement component 3a receptor 1
CAPN9 calpain 9
CD1B CD1b molecule
CD48 CD48 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CELF2 CUGBP, Elav-like family member 2
CFP complement factor properdin
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLSTN3 calsyntenin 3
CPEB1 cytoplasmic polyadenylation element binding protein 1
CRYGC crystallin, gamma C
CTRC chymotrypsin C (caldecrin)
ECE1 endothelin converting enzyme 1
EFS embryonal Fyn-associated substrate
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ERN2 endoplasmic reticulum to nucleus signaling 2
EXPH5 exophilin 5
FGF16 fibroblast growth factor 16
FGF4 fibroblast growth factor 4
FGF6 fibroblast growth factor 6
FLRT2 fibronectin leucine rich transmembrane protein 2
FRMD1 FERM domain containing 1
FRY furry homolog (Drosophila)
GPR137 G protein-coupled receptor 137
GRK5 G protein-coupled receptor kinase 5
GRM7 glutamate receptor, metabotropic 7
GRM8 glutamate receptor, metabotropic 8
GSK3A glycogen synthase kinase 3 alpha
HDAC7 histone deacetylase 7
HRH4 histamine receptor H4
IDUA iduronidase, alpha-L-
IGF1R insulin-like growth factor 1 receptor
IGHA1 immunoglobulin heavy constant alpha 1
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIF25 kinesin family member 25
LGALS8 lectin, galactoside-binding, soluble, 8
LRRC6 leucine rich repeat containing 6
MIP major intrinsic protein of lens fiber
MMP25 matrix metallopeptidase 25
MRPL41 mitochondrial ribosomal protein L41
MX2 MX dynamin-like GTPase 2
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NCOR2 nuclear receptor corepressor 2
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PLCB2 phospholipase C, beta 2
PMFBP1 polyamine modulated factor 1 binding protein 1
POU5F1B POU class 5 homeobox 1B
PTGIS prostaglandin I2 (prostacyclin) synthase
PTHLH parathyroid hormone-like hormone
RAB3B RAB3B, member RAS oncogene family
RARB retinoic acid receptor, beta
REC8 REC8 meiotic recombination protein
RND1 Rho family GTPase 1
RYR1 ryanodine receptor 1 (skeletal)
S100A8 S100 calcium binding protein A8
SCUBE3 signal peptide, CUB domain, EGF-like 3
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIGLEC8 sialic acid binding Ig-like lectin 8
SLA Src-like-adaptor
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC35G2 solute carrier family 35, member G2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SMAD6 SMAD family member 6
SPAG6 sperm associated antigen 6
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPRR3 small proline-rich protein 3
SYT5 synaptotagmin V
TBX2 T-box 2
TBXA2R thromboxane A2 receptor
TCP11L1 t-complex 11, testis-specific-like 1
TEX14 testis expressed 14
THSD4 thrombospondin, type I, domain containing 4
TLE4 transducin-like enhancer of split 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNS1 tensin 1
TP53I11 tumor protein p53 inducible protein 11
TRIB2 tribbles pseudokinase 2
UBXN1 UBX domain protein 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT10B wingless-type MMTV integration site family, member 10B
ZNF528 zinc finger protein 528
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARRB2 arrestin, beta 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BGLAP bone gamma-carboxyglutamate (gla) protein
C2ORF27A chromosome 2 open reading frame 27A
CBX8 chromobox homolog 8
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD34 CD34 molecule
CD80 CD80 molecule
CDK20 cyclin-dependent kinase 20
CEP85 centrosomal protein 85kDa
CHKB choline kinase beta
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCF1 cardiotrophin-like cytokine factor 1
CORO7 coronin 7
CPPED1 calcineurin-like phosphoesterase domain containing 1
CUZD1 CUB and zona pellucida-like domains 1
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DOCK1 dedicator of cytokinesis 1
ELOVL4 ELOVL fatty acid elongase 4
FAM198B family with sequence similarity 198, member B
FKBP10 FK506 binding protein 10, 65 kDa
FLJ11710 uncharacterized protein FLJ11710
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GSTCD glutathione S-transferase, C-terminal domain containing
GUSBP3 glucuronidase, beta pseudogene 3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC4 homeobox C4
INO80D INO80 complex subunit D
INPP5J inositol polyphosphate-5-phosphatase J
ITPKB inositol-trisphosphate 3-kinase B
KLHDC8A kelch domain containing 8A
KRT13 keratin 13, type I
LARP6 La ribonucleoprotein domain family, member 6
LHX6 LIM homeobox 6
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MFSD11 major facilitator superfamily domain containing 11
MSI1 musashi RNA-binding protein 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NME5 NME/NM23 family member 5
NRSN2 neurensin 2
NT5DC3 5'-nucleotidase domain containing 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCDHA6 protocadherin alpha 6
PCDHB13 protocadherin beta 13
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PEX26 peroxisomal biogenesis factor 26
PGP phosphoglycolate phosphatase
PHEX phosphate regulating endopeptidase homolog, X-linked
PLCD1 phospholipase C, delta 1
PLD3 phospholipase D family, member 3
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRODH proline dehydrogenase (oxidase) 1
PROS1 protein S (alpha)
PRPF39 pre-mRNA processing factor 39
RHOBTB2 Rho-related BTB domain containing 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF122 ring finger protein 122
RPL23AP32 ribosomal protein L23a pseudogene 32
SCRN3 secernin 3
SLPI secretory leukocyte peptidase inhibitor
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNTA1 syntrophin, alpha 1
SP1 Sp1 transcription factor
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD13 StAR-related lipid transfer (START) domain containing 13
STIM1 stromal interaction molecule 1
TBC1D19 TBC1 domain family, member 19
TBKBP1 TBK1 binding protein 1
TCP10 t-complex 10
TCTN2 tectonic family member 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMPRSS4 transmembrane protease, serine 4
TSNAXIP1 translin-associated factor X interacting protein 1
TUBA3C tubulin, alpha 3c
USB1 U6 snRNA biogenesis 1
VIPR1 vasoactive intestinal peptide receptor 1
WDR33 WD repeat domain 33
XK X-linked Kx blood group
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
YY2 YY2 transcription factor
ZBTB22 zinc finger and BTB domain containing 22
ZBTB6 zinc finger and BTB domain containing 6
ZFAND3 zinc finger, AN1-type domain 3
ZFHX3 zinc finger homeobox 3
ZNF197 zinc finger protein 197
ZNF324 zinc finger protein 324
ZNF862 zinc finger protein 862