hydrastinine-5494 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the hydrastinine-5494 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ADARB1 adenosine deaminase, RNA-specific, B1
ADGRL1 adhesion G protein-coupled receptor L1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATF5 activating transcription factor 5
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BMP1 bone morphogenetic protein 1
BTD biotinidase
BTN3A1 butyrophilin, subfamily 3, member A1
C10ORF10 chromosome 10 open reading frame 10
CCDC93 coiled-coil domain containing 93
CCNT2 cyclin T2
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCA1 chloride channel accessory 1
CLCF1 cardiotrophin-like cytokine factor 1
CLTC clathrin, heavy chain (Hc)
CNTN1 contactin 1
COPZ2 coatomer protein complex, subunit zeta 2
CORO2B coronin, actin binding protein, 2B
CRTC1 CREB regulated transcription coactivator 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
EDN2 endothelin 2
EPHA5 EPH receptor A5
EPYC epiphycan
FAM149B1 family with sequence similarity 149, member B1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FECH ferrochelatase
FNTB farnesyltransferase, CAAX box, beta
FSTL1 follistatin-like 1
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HIRA histone cell cycle regulator
HIST1H2AL histone cluster 1, H2al
IGHA1 immunoglobulin heavy constant alpha 1
IL23A interleukin 23, alpha subunit p19
JAG1 jagged 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCTD12 potassium channel tetramerization domain containing 12
KIF5A kinesin family member 5A
LOC257152 uncharacterized LOC257152
LRRC15 leucine rich repeat containing 15
MARK4 MAP/microtubule affinity-regulating kinase 4
MAU2 MAU2 sister chromatid cohesion factor
MBNL2 muscleblind-like splicing regulator 2
MEF2C myocyte enhancer factor 2C
METTL16 methyltransferase like 16
MIP major intrinsic protein of lens fiber
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MTM1 myotubularin 1
MZF1 myeloid zinc finger 1
NECAP2 NECAP endocytosis associated 2
NPPA natriuretic peptide A
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCDHGB5 protocadherin gamma subfamily B, 5
PCNX pecanex homolog (Drosophila)
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLAUR plasminogen activator, urokinase receptor
PLD2 phospholipase D2
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTH1R parathyroid hormone 1 receptor
RAD23B RAD23 homolog B (S. cerevisiae)
RAI2 retinoic acid induced 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RCN3 reticulocalbin 3, EF-hand calcium binding domain
SEC24D SEC24 family member D
SENP5 SUMO1/sentrin specific peptidase 5
SIRT5 sirtuin 5
SLC16A4 solute carrier family 16, member 4
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTBN5 spectrin, beta, non-erythrocytic 5
SRRT serrate, RNA effector molecule
SSPN sarcospan
STEAP4 STEAP family member 4
STK11 serine/threonine kinase 11
TFF2 trefoil factor 2
THOC5 THO complex 5
TM4SF5 transmembrane 4 L six family member 5
TMEM209 transmembrane protein 209
TMEM242 transmembrane protein 242
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WFDC2 WAP four-disulfide core domain 2
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADTRP androgen-dependent TFPI-regulating protein
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AMPD2 adenosine monophosphate deaminase 2
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARSB arylsulfatase B
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BBC3 BCL2 binding component 3
BCL9 B-cell CLL/lymphoma 9
C1QTNF3 C1q and tumor necrosis factor related protein 3
C5 complement component 5
CCDC85C coiled-coil domain containing 85C
CCDC9 coiled-coil domain containing 9
CLASRP CLK4-associating serine/arginine rich protein
CLEC4E C-type lectin domain family 4, member E
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CTC1 CTS telomere maintenance complex component 1
CTNNBL1 catenin, beta like 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXADR coxsackie virus and adenovirus receptor
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DESI1 desumoylating isopeptidase 1
DNAL4 dynein, axonemal, light chain 4
DSCAM Down syndrome cell adhesion molecule
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM110B family with sequence similarity 110, member B
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GPX2 glutathione peroxidase 2
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IL2 interleukin 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT24 keratin 24, type I
KRT31 keratin 31, type I
LOC100286895 cell division cycle 27 homolog pseudogene
LOC729164 hCG1732469
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRP2 low density lipoprotein receptor-related protein 2
LY6D lymphocyte antigen 6 complex, locus D
LZTR1 leucine-zipper-like transcription regulator 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED9 mediator complex subunit 9
MEIS1 Meis homeobox 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYO1F myosin IF
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NKAIN1 Na+/K+ transporting ATPase interacting 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPM3 nucleophosmin/nucleoplasmin 3
NPTX1 neuronal pentraxin I
OGFRL1 opioid growth factor receptor-like 1
PARP16 poly (ADP-ribose) polymerase family, member 16
PC pyruvate carboxylase
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLSCR4 phospholipid scramblase 4
PODXL2 podocalyxin-like 2
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM42 RNA binding motif protein 42
REEP4 receptor accessory protein 4
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGS2 regulator of G-protein signaling 2
RNF122 ring finger protein 122
SARS2 seryl-tRNA synthetase 2, mitochondrial
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SETD1A SET domain containing 1A
SH2D4A SH2 domain containing 4A
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STAG3 stromal antigen 3
STARD13 StAR-related lipid transfer (START) domain containing 13
STX4 syntaxin 4
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX19 T-box 19
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THBS3 thrombospondin 3
TMEM183A transmembrane protein 183A
TMEM62 transmembrane protein 62
TRAIP TRAF interacting protein
TSPYL2 TSPY-like 2
TUBG1 tubulin, gamma 1
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
URM1 ubiquitin related modifier 1
USB1 U6 snRNA biogenesis 1
VGF VGF nerve growth factor inducible
ZNF136 zinc finger protein 136
ZNF34 zinc finger protein 34
ZNF442 zinc finger protein 442
ZNF639 zinc finger protein 639
ZNF747 zinc finger protein 747