hydroquinine-5789 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the hydroquinine-5789 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM20 ADAM metallopeptidase domain 20
ADAMDEC1 ADAM-like, decysin 1
ADCK2 aarF domain containing kinase 2
ADRA1D adrenoceptor alpha 1D
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARR3 arrestin 3, retinal (X-arrestin)
ATF7IP activating transcription factor 7 interacting protein
ATP4B ATPase, H+/K+ exchanging, beta polypeptide
BCAN brevican
C1ORF54 chromosome 1 open reading frame 54
C8B complement component 8, beta polypeptide
CACFD1 calcium channel flower domain containing 1
CEMP1 cementum protein 1
COLEC12 collectin sub-family member 12
CPNE7 copine VII
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DSCR4 Down syndrome critical region 4
DVL2 dishevelled segment polarity protein 2
EDN1 endothelin 1
EIF5A2 eukaryotic translation initiation factor 5A2
ELMO3 engulfment and cell motility 3
FAIM2 Fas apoptotic inhibitory molecule 2
FOLR1 folate receptor 1 (adult)
FRMD1 FERM domain containing 1
FRMPD4 FERM and PDZ domain containing 4
GIPC2 GIPC PDZ domain containing family, member 2
GP5 glycoprotein V (platelet)
GPR50 G protein-coupled receptor 50
GRM1 glutamate receptor, metabotropic 1
GRM7 glutamate receptor, metabotropic 7
HDAC11 histone deacetylase 11
HLA-DOB major histocompatibility complex, class II, DO beta
HMOX1 heme oxygenase 1
IL36A interleukin 36, alpha
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIF1C kinesin family member 1C
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KITLG KIT ligand
KLHL20 kelch-like family member 20
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LRRN3 leucine rich repeat neuronal 3
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED25 mediator complex subunit 25
MFAP3 microfibrillar-associated protein 3
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MOCS1 molybdenum cofactor synthesis 1
MORN1 MORN repeat containing 1
MRPS18C mitochondrial ribosomal protein S18C
MSC musculin
MTRF1L mitochondrial translational release factor 1-like
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCOR2 nuclear receptor corepressor 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPC1 Niemann-Pick disease, type C1
OGDHL oxoglutarate dehydrogenase-like
ORC5 origin recognition complex, subunit 5
PCDH12 protocadherin 12
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE10A phosphodiesterase 10A
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDGFB platelet-derived growth factor beta polypeptide
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLSCR2 phospholipid scramblase 2
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD51B RAD51 paralog B
RASA3 RAS p21 protein activator 3
RBM12B RNA binding motif protein 12B
REPS1 RALBP1 associated Eps domain containing 1
RPL35A ribosomal protein L35a
RTCA RNA 3'-terminal phosphate cyclase
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH3BP2 SH3-domain binding protein 2
SIX3 SIX homeobox 3
SLC19A3 solute carrier family 19 (thiamine transporter), member 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLMO1 slowmo homolog 1 (Drosophila)
SOSTDC1 sclerostin domain containing 1
TADA2A transcriptional adaptor 2A
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
WT1-AS WT1 antisense RNA
XYLB xylulokinase homolog (H. influenzae)
ZC2HC1C zinc finger, C2HC-type containing 1C
ZER1 zyg-11 related, cell cycle regulator
ZNF549 zinc finger protein 549
ZNF695 zinc finger protein 695
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABHD8 abhydrolase domain containing 8
AGMAT agmatine ureohydrolase (agmatinase)
AGO4 argonaute RISC catalytic component 4
AK5 adenylate kinase 5
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASTE1 asteroid homolog 1 (Drosophila)
BAHCC1 BAH domain and coiled-coil containing 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEND5 BEN domain containing 5
BET1L Bet1 golgi vesicular membrane trafficking protein-like
C11ORF63 chromosome 11 open reading frame 63
CDK6 cyclin-dependent kinase 6
CFAP45 cilia and flagella associated protein 45
CHEK2 checkpoint kinase 2
CHKB choline kinase beta
CHMP6 charged multivesicular body protein 6
CREB5 cAMP responsive element binding protein 5
CSRNP3 cysteine-serine-rich nuclear protein 3
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DTX2 deltex 2, E3 ubiquitin ligase
EGR2 early growth response 2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERCC2 excision repair cross-complementation group 2
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GLS2 glutaminase 2 (liver, mitochondrial)
GPATCH3 G patch domain containing 3
GPR19 G protein-coupled receptor 19
GPR3 G protein-coupled receptor 3
HDAC5 histone deacetylase 5
HIRA histone cell cycle regulator
HIST1H2BJ histone cluster 1, H2bj
HIST1H3G histone cluster 1, H3g
HIST1H4D histone cluster 1, H4d
HMHA1 histocompatibility (minor) HA-1
HOXA7 homeobox A7
HOXC10 homeobox C10
HOXC11 homeobox C11
HSPA1L heat shock 70kDa protein 1-like
IFT54 intraflagellar transport 54
IL2 interleukin 2
IRF1 interferon regulatory factor 1
ITK IL2-inducible T-cell kinase
KCTD15 potassium channel tetramerization domain containing 15
KIAA1549L KIAA1549-like
KRT8P12 keratin 8 pseudogene 12
LOC100287590 uncharacterized LOC100287590
LRRK1 leucine-rich repeat kinase 1
MANBA mannosidase, beta A, lysosomal
MAST3 microtubule associated serine/threonine kinase 3
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MVD mevalonate (diphospho) decarboxylase
MYO1F myosin IF
NINL ninein-like
NTSR1 neurotensin receptor 1 (high affinity)
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PACS1 phosphofurin acidic cluster sorting protein 1
PARD6A par-6 family cell polarity regulator alpha
PCDH17 protocadherin 17
PDE8B phosphodiesterase 8B
PRICKLE3 prickle homolog 3 (Drosophila)
PRSS22 protease, serine, 22
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRH protein tyrosine phosphatase, receptor type, H
RANBP17 RAN binding protein 17
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RPL23AP32 ribosomal protein L23a pseudogene 32
SELL selectin L
SH2D2A SH2 domain containing 2A
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC46A3 solute carrier family 46, member 3
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLITRK5 SLIT and NTRK-like family, member 5
SPRYD7 SPRY domain containing 7
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAGLN transgelin
TFRC transferrin receptor
THRB thyroid hormone receptor, beta
TMEM121 transmembrane protein 121
TMEM209 transmembrane protein 209
TOM1 target of myb1 (chicken)
TPCN1 two pore segment channel 1
TSC22D4 TSC22 domain family, member 4
TUBA3C tubulin, alpha 3c
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UNC119 unc-119 homolog (C. elegans)
ZBTB6 zinc finger and BTB domain containing 6
ZFHX3 zinc finger homeobox 3
ZFP30 ZFP30 zinc finger protein
ZNF10 zinc finger protein 10
ZNF358 zinc finger protein 358
ZNF606 zinc finger protein 606
ZNF654 zinc finger protein 654
ZNF701 zinc finger protein 701