hydroxyachillin-2157 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the hydroxyachillin-2157 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABHD2 abhydrolase domain containing 2
ACACB acetyl-CoA carboxylase beta
AHNAK2 AHNAK nucleoprotein 2
ANXA2P3 annexin A2 pseudogene 3
APAF1 apoptotic peptidase activating factor 1
ATAD2B ATPase family, AAA domain containing 2B
BCAS3 breast carcinoma amplified sequence 3
BMP2 bone morphogenetic protein 2
BSDC1 BSD domain containing 1
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CD47 CD47 molecule
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSRP2 cysteine and glycine-rich protein 2
CUL2 cullin 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
EIF1 eukaryotic translation initiation factor 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPS8L1 EPS8-like 1
F2RL3 coagulation factor II (thrombin) receptor-like 3
FAM168A family with sequence similarity 168, member A
FAM49A family with sequence similarity 49, member A
FCAR Fc fragment of IgA receptor
GFOD2 glucose-fructose oxidoreductase domain containing 2
GLE1 GLE1 RNA export mediator
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR137 G protein-coupled receptor 137
GPR153 G protein-coupled receptor 153
GTPBP1 GTP binding protein 1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIST1H4E histone cluster 1, H4e
IFI6 interferon, alpha-inducible protein 6
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IL27RA interleukin 27 receptor, alpha
IL6ST interleukin 6 signal transducer
IRF4 interferon regulatory factor 4
KLC2 kinesin light chain 2
KRAS Kirsten rat sarcoma viral oncogene homolog
KRIT1 KRIT1, ankyrin repeat containing
LOC257152 uncharacterized LOC257152
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRRC6 leucine rich repeat containing 6
MAP1A microtubule-associated protein 1A
MED25 mediator complex subunit 25
MFAP3 microfibrillar-associated protein 3
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
NDNF neuron-derived neurotrophic factor
NDRG2 NDRG family member 2
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NR3C2 nuclear receptor subfamily 3, group C, member 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUMA1 nuclear mitotic apparatus protein 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PHC1 polyhomeotic homolog 1 (Drosophila)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLA2G3 phospholipase A2, group III
PLD1 phospholipase D1, phosphatidylcholine-specific
POFUT2 protein O-fucosyltransferase 2
PPARD peroxisome proliferator-activated receptor delta
PPP5C protein phosphatase 5, catalytic subunit
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PSG11 pregnancy specific beta-1-glycoprotein 11
PTAFR platelet-activating factor receptor
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYGB phosphorylase, glycogen; brain
RGS5 regulator of G-protein signaling 5
RRBP1 ribosome binding protein 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLIT2 slit homolog 2 (Drosophila)
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOX4 SRY (sex determining region Y)-box 4
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPHK2 sphingosine kinase 2
SRPK2 SRSF protein kinase 2
STS steroid sulfatase (microsomal), isozyme S
THAP9 THAP domain containing 9
TPD52L1 tumor protein D52-like 1
TRIL TLR4 interactor with leucine-rich repeats
TRIM23 tripartite motif containing 23
TSPAN31 tetraspanin 31
UBA6 ubiquitin-like modifier activating enzyme 6
UBR2 ubiquitin protein ligase E3 component n-recognin 2
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP22 ubiquitin specific peptidase 22
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VPRBP Vpr (HIV-1) binding protein
YTHDC2 YTH domain containing 2
ZCCHC24 zinc finger, CCHC domain containing 24
ZER1 zyg-11 related, cell cycle regulator
ZNF224 zinc finger protein 224
ZNF32 zinc finger protein 32

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
A2M alpha-2-macroglobulin
AIM2 absent in melanoma 2
ALPK1 alpha-kinase 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARG1 arginase 1
ATAT1 alpha tubulin acetyltransferase 1
AXIN1 axin 1
BHLHE41 basic helix-loop-helix family, member e41
C2ORF27A chromosome 2 open reading frame 27A
C2ORF44 chromosome 2 open reading frame 44
CAPN5 calpain 5
CCDC106 coiled-coil domain containing 106
CCDC186 coiled-coil domain containing 186
CCDC85C coiled-coil domain containing 85C
CD34 CD34 molecule
CD70 CD70 molecule
CDKL3 cyclin-dependent kinase-like 3
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CIDEB cell death-inducing DFFA-like effector b
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCF1 cardiotrophin-like cytokine factor 1
CLEC2D C-type lectin domain family 2, member D
CNTN1 contactin 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDN dendrin
DNMBP dynamin binding protein
DOK5 docking protein 5
EDAR ectodysplasin A receptor
ETV4 ets variant 4
EXOSC1 exosome component 1
FBRS fibrosin
FKBP5 FK506 binding protein 5
FOXC1 forkhead box C1
FRMD1 FERM domain containing 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLI3 GLI family zinc finger 3
GPR27 G protein-coupled receptor 27
GSDMD gasdermin D
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AJ histone cluster 1, H2aj
HP haptoglobin
HPSE heparanase
ITGA10 integrin, alpha 10
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF1 Kruppel-like factor 1 (erythroid)
LIME1 Lck interacting transmembrane adaptor 1
LOC390998 ribosomal protein L10 pseudogene
LTBP2 latent transforming growth factor beta binding protein 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MCC mutated in colorectal cancers
MLPH melanophilin
MMP9 matrix metallopeptidase 9
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPL28 mitochondrial ribosomal protein L28
MYOZ3 myozenin 3
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NBEAL2 neurobeachin-like 2
NKX3-2 NK3 homeobox 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PER3 period circadian clock 3
PIPOX pipecolic acid oxidase
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSKH1 protein serine kinase H1
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNF39 ring finger protein 39
SALL2 spalt-like transcription factor 2
SCD5 stearoyl-CoA desaturase 5
SHPK sedoheptulokinase
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SNAI1 snail family zinc finger 1
SOCS7 suppressor of cytokine signaling 7
STON1 stonin 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAGLN transgelin
TBXAS1 thromboxane A synthase 1 (platelet)
TFF2 trefoil factor 2
THBS3 thrombospondin 3
THEM6 thioesterase superfamily member 6
TMEM212 transmembrane protein 212
TOLLIP toll interacting protein
TRAF2 TNF receptor-associated factor 2
TTC30A tetratricopeptide repeat domain 30A
UNC119 unc-119 homolog (C. elegans)
URM1 ubiquitin related modifier 1
USP19 ubiquitin specific peptidase 19
ZFHX2 zinc finger homeobox 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF41 zinc finger protein 41
ZNF492 zinc finger protein 492