hymecromone-5684 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the hymecromone-5684 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTSL4 ADAMTS-like 4
ADGRE3 adhesion G protein-coupled receptor E3
AKAP1 A kinase (PRKA) anchor protein 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BHMT2 betaine--homocysteine S-methyltransferase 2
C11ORF30 chromosome 11 open reading frame 30
C14ORF79 chromosome 14 open reading frame 79
C5ORF45 chromosome 5 open reading frame 45
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CCDC71 coiled-coil domain containing 71
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEP250 centrosomal protein 250kDa
CFAP69 cilia and flagella associated protein 69
CLEC11A C-type lectin domain family 11, member A
COL5A2 collagen, type V, alpha 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRY2 cryptochrome circadian clock 2
CSTA cystatin A (stefin A)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DPPA4 developmental pluripotency associated 4
DRD2 dopamine receptor D2
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EPB41L1 erythrocyte membrane protein band 4.1-like 1
ERO1LB ERO1-like beta (S. cerevisiae)
FAM53B family with sequence similarity 53, member B
FBXO2 F-box protein 2
FGFBP1 fibroblast growth factor binding protein 1
FHL1 four and a half LIM domains 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GK glycerol kinase
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIP2 glutamate receptor interacting protein 2
HIST1H1T histone cluster 1, H1t
HIST1H4E histone cluster 1, H4e
HOXB5 homeobox B5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HRASLS2 HRAS-like suppressor 2
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGLJ3 immunoglobulin lambda joining 3
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM5C lysine (K)-specific demethylase 5C
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LOC390998 ribosomal protein L10 pseudogene
LTBP4 latent transforming growth factor beta binding protein 4
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAGEA5 melanoma antigen family A5
MAOA monoamine oxidase A
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MBD3 methyl-CpG binding domain protein 3
MECOM MDS1 and EVI1 complex locus
MR1 major histocompatibility complex, class I-related
MYOD1 myogenic differentiation 1
MYOM2 myomesin 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NF1 neurofibromin 1
NOL12 nucleolar protein 12
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
ONECUT2 one cut homeobox 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAX2 paired box 2
PDE4DIP phosphodiesterase 4D interacting protein
PGLYRP4 peptidoglycan recognition protein 4
PQLC2 PQ loop repeat containing 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RB1 retinoblastoma 1
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIGLEC7 sialic acid binding Ig-like lectin 7
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SNTA1 syntrophin, alpha 1
SOX30 SRY (sex determining region Y)-box 30
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSPN sarcospan
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STRN3 striatin, calmodulin binding protein 3
SYN1 synapsin I
TCP10 t-complex 10
TCP11L1 t-complex 11, testis-specific-like 1
TECTA tectorin alpha
THBS3 thrombospondin 3
TMEM242 transmembrane protein 242
TMEM8B transmembrane protein 8B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNN tenascin N
TPMT thiopurine S-methyltransferase
TRIB2 tribbles pseudokinase 2
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC4 transient receptor potential cation channel, subfamily C, member 4
ZBTB17 zinc finger and BTB domain containing 17

decreased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ACAD10 acyl-CoA dehydrogenase family, member 10
ACTL8 actin-like 8
ADAM15 ADAM metallopeptidase domain 15
ADAP2 ArfGAP with dual PH domains 2
AHDC1 AT hook, DNA binding motif, containing 1
AMH anti-Mullerian hormone
AMT aminomethyltransferase
APLP1 amyloid beta (A4) precursor-like protein 1
ARMCX2 armadillo repeat containing, X-linked 2
ARRB1 arrestin, beta 1
BMP15 bone morphogenetic protein 15
BST2 bone marrow stromal cell antigen 2
C17ORF80 chromosome 17 open reading frame 80
C1ORF105 chromosome 1 open reading frame 105
CAPN5 calpain 5
CCP110 centriolar coiled coil protein 110kDa
CD70 CD70 molecule
CDHR2 cadherin-related family member 2
CDKL3 cyclin-dependent kinase-like 3
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CIR1 corepressor interacting with RBPJ, 1
CLGN calmegin
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNGB3 cyclic nucleotide gated channel beta 3
CRIP1 cysteine-rich protein 1 (intestinal)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DBR1 debranching RNA lariats 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGAT1 diacylglycerol O-acyltransferase 1
ECHDC3 enoyl CoA hydratase domain containing 3
ERN2 endoplasmic reticulum to nucleus signaling 2
EXTL3 exostosin-like glycosyltransferase 3
FAM169A family with sequence similarity 169, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FMO4 flavin containing monooxygenase 4
GPR3 G protein-coupled receptor 3
HDAC11 histone deacetylase 11
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOXA4 homeobox A4
IFITM1 interferon induced transmembrane protein 1
IFT54 intraflagellar transport 54
INPP1 inositol polyphosphate-1-phosphatase
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KDM8 lysine (K)-specific demethylase 8
KIAA0754 KIAA0754
KLF2 Kruppel-like factor 2
LAX1 lymphocyte transmembrane adaptor 1
LIME1 Lck interacting transmembrane adaptor 1
LOC100272216 uncharacterized LOC100272216
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRP3 low density lipoprotein receptor-related protein 3
LRRC37A3 leucine rich repeat containing 37, member A3
LRRC61 leucine rich repeat containing 61
LTC4S leukotriene C4 synthase
MED9 mediator complex subunit 9
MGC12488
MYL5 myosin, light chain 5, regulatory
NES nestin
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPFFR1 neuropeptide FF receptor 1
PBLD phenazine biosynthesis-like protein domain containing
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGPEP1 pyroglutamyl-peptidase I
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
POLH polymerase (DNA directed), eta
POU4F2 POU class 4 homeobox 2
PPT2 palmitoyl-protein thioesterase 2
PROL1 proline rich, lacrimal 1
PTK6 protein tyrosine kinase 6
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RAB3D RAB3D, member RAS oncogene family
RIN2 Ras and Rab interactor 2
RIPK4 receptor-interacting serine-threonine kinase 4
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPH3AL rabphilin 3A-like (without C2 domains)
SCN10A sodium channel, voltage gated, type X alpha subunit
SHARPIN SHANK-associated RH domain interactor
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SPAG4 sperm associated antigen 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRPX sushi-repeat containing protein, X-linked
STIM1 stromal interaction molecule 1
TBX19 T-box 19
TDRD12 tudor domain containing 12
TGFBR3 transforming growth factor, beta receptor III
TIGD6 tigger transposable element derived 6
TMC5 transmembrane channel-like 5
TMEM180 transmembrane protein 180
TSC22D4 TSC22 domain family, member 4
ZBED1 zinc finger, BED-type containing 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF134 zinc finger protein 134
ZNF205 zinc finger protein 205