hyoscyamine-2108 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the hyoscyamine-2108 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX3 acyl-CoA oxidase 3, pristanoyl
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDOB aldolase B, fructose-bisphosphate
APOA1 apolipoprotein A-I
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C2CD2L C2CD2-like
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCDC28B coiled-coil domain containing 28B
CDH8 cadherin 8, type 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLEC1A C-type lectin domain family 1, member A
CNR2 cannabinoid receptor 2 (macrophage)
CYB561 cytochrome b561
DCAF15 DDB1 and CUL4 associated factor 15
DEFA4 defensin, alpha 4, corticostatin
DLK2 delta-like 2 homolog (Drosophila)
EPHA5 EPH receptor A5
FKRP fukutin related protein
FNDC4 fibronectin type III domain containing 4
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAB1 GRB2-associated binding protein 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GDF5 growth differentiation factor 5
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPM6A glycoprotein M6A
GPR162 G protein-coupled receptor 162
GSK3A glycogen synthase kinase 3 alpha
HIST1H1D histone cluster 1, H1d
HOXB5 homeobox B5
HOXD9 homeobox D9
HPS1 Hermansky-Pudlak syndrome 1
IGSF1 immunoglobulin superfamily, member 1
IL19 interleukin 19
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JUND jun D proto-oncogene
LINC00260 long intergenic non-protein coding RNA 260
LOC390998 ribosomal protein L10 pseudogene
LOXL3 lysyl oxidase-like 3
LPA lipoprotein, Lp(a)
LPAR4 lysophosphatidic acid receptor 4
LRRC23 leucine rich repeat containing 23
LRRN3 leucine rich repeat neuronal 3
LUM lumican
LYPD3 LY6/PLAUR domain containing 3
MDFI MyoD family inhibitor
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MUC3B mucin 3B, cell surface associated
MX2 MX dynamin-like GTPase 2
MYH15 myosin, heavy chain 15
NEBL nebulette
NF1 neurofibromin 1
NLRP3 NLR family, pyrin domain containing 3
NPC1L1 NPC1-like 1
NPY1R neuropeptide Y receptor Y1
NUP214 nucleoporin 214kDa
PCDH11Y protocadherin 11 Y-linked
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PDLIM7 PDZ and LIM domain 7 (enigma)
PHF1 PHD finger protein 1
PRMT2IP PRMT2 interacting protein
PRPH peripherin
PRR14L proline rich 14-like
PTAFR platelet-activating factor receptor
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RBM12B RNA binding motif protein 12B
REST RE1-silencing transcription factor
RGS10 regulator of G-protein signaling 10
RNF43 ring finger protein 43
RPL10L ribosomal protein L10-like
SACK1E scaffolding CK1 anchoring protein E
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAP30 Sin3A-associated protein, 30kDa
SCARB1 scavenger receptor class B, member 1
SELL selectin L
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SOGA1 suppressor of glucose, autophagy associated 1
SOX12 SRY (sex determining region Y)-box 12
SRRM2 serine/arginine repetitive matrix 2
STAB1 stabilin 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THRA thyroid hormone receptor, alpha
TMEM180 transmembrane protein 180
TRIM14 tripartite motif containing 14
TRIM33 tripartite motif containing 33
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TTC38 tetratricopeptide repeat domain 38
TTC39A tetratricopeptide repeat domain 39A
UBTD1 ubiquitin domain containing 1
WIPF1 WAS/WASL interacting protein family, member 1
WNT16 wingless-type MMTV integration site family, member 16
XDH xanthine dehydrogenase
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZMYM5 zinc finger, MYM-type 5
ZNF492 zinc finger protein 492
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACYP2 acylphosphatase 2, muscle type
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AKIP1 A kinase (PRKA) interacting protein 1
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ASTE1 asteroid homolog 1 (Drosophila)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BGLAP bone gamma-carboxyglutamate (gla) protein
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CCS copper chaperone for superoxide dismutase
CDC37L1 cell division cycle 37-like 1
CHKB choline kinase beta
CIR1 corepressor interacting with RBPJ, 1
CLDN14 claudin 14
CLSPN claspin
CNN2 calponin 2
COQ4 coenzyme Q4
CTNNBL1 catenin, beta like 1
CUL9 cullin 9
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOCK1 dedicator of cytokinesis 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EML4 echinoderm microtubule associated protein like 4
ERAP2 endoplasmic reticulum aminopeptidase 2
EXOC5 exocyst complex component 5
FEM1C fem-1 homolog c (C. elegans)
FER fer (fps/fes related) tyrosine kinase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJC1 gap junction protein, gamma 1, 45kDa
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HIRA histone cell cycle regulator
IFT46 intraflagellar transport 46
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
JMJD4 jumonji domain containing 4
KIAA0894 KIAA0894 protein
KLHL3 kelch-like family member 3
KRT34 keratin 34, type I
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRRC8D leucine rich repeat containing 8 family, member D
LYRM2 LYR motif containing 2
MNX1 motor neuron and pancreas homeobox 1
MXD3 MAX dimerization protein 3
NECAB3 N-terminal EF-hand calcium binding protein 3
NINJ1 ninjurin 1
NMB neuromedin B
NXPE3 neurexophilin and PC-esterase domain family, member 3
OTUD3 OTU deubiquitinase 3
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PECR peroxisomal trans-2-enoyl-CoA reductase
PHACTR4 phosphatase and actin regulator 4
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCD1 phospholipase C, delta 1
POLM polymerase (DNA directed), mu
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RBM42 RNA binding motif protein 42
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RSF1 remodeling and spacing factor 1
RUSC2 RUN and SH3 domain containing 2
SHROOM2 shroom family member 2
SKA1 spindle and kinetochore associated complex subunit 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPATA7 spermatogenesis associated 7
STX5 syntaxin 5
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TOR4A torsin family 4, member A
TPMT thiopurine S-methyltransferase
TRIM16 tripartite motif containing 16
TRIM52 tripartite motif containing 52
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TTC33 tetratricopeptide repeat domain 33
TUBG2 tubulin, gamma 2
TUBGCP5 tubulin, gamma complex associated protein 5
UBXN6 UBX domain protein 6
UBXN8 UBX domain protein 8
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF112 zinc finger protein 112
ZNF160 zinc finger protein 160
ZNF264 zinc finger protein 264
ZNF33B zinc finger protein 33B
ZNF574 zinc finger protein 574
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721
ZNF91 zinc finger protein 91