hyperaldosteronism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands. (Human Disease Ontology, DOID_446)
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Genes

92 genes co-occuring with the disease hyperaldosteronism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
REN renin 2.81652
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.60576
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 2.13466
NR3C2 nuclear receptor subfamily 3, group C, member 2 2.10424
POMC proopiomelanocortin 1.90335
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.81465
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.4834
CLCNKB chloride channel, voltage-sensitive Kb 1.4057
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 1.33283
KCNK9 potassium channel, two pore domain subfamily K, member 9 1.2595
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.21348
ACE angiotensin I converting enzyme 1.12952
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.11099
AVP arginine vasopressin 1.05093
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 1.02692
BSND barttin CLCNK-type chloride channel accessory beta subunit 1.01174
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.00794
RBAK RB-associated KRAB zinc finger 0.998236
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.952021
ZNF226 zinc finger protein 226 0.931656
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.920085
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.914727
NPPA natriuretic peptide A 0.887618
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.886389
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.88475
ARMC5 armadillo repeat containing 5 0.825358
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 0.821257
KCNK3 potassium channel, two pore domain subfamily K, member 3 0.812642
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.733001
MGAM maltase-glucoamylase 0.725716
WNK4 WNK lysine deficient protein kinase 4 0.725311
SCNN1B sodium channel, non voltage gated 1 beta subunit 0.714005
KL klotho 0.709975
ADD1 adducin 1 (alpha) 0.707559
PCP4 Purkinje cell protein 4 0.653671
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.615138
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.595233
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.591337
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 0.590558
CRY1 cryptochrome circadian clock 1 0.58939
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.571884
TRPM6 transient receptor potential cation channel, subfamily M, member 6 0.571884
CRY2 cryptochrome circadian clock 2 0.549359
WNK1 WNK lysine deficient protein kinase 1 0.547419
DNAH8 dynein, axonemal, heavy chain 8 0.530768
PTH parathyroid hormone 0.52729
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.516494
FDX1 ferredoxin 1 0.515725
SGK1 serum/glucocorticoid regulated kinase 1 0.508808
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 0.470332
PBK PDZ binding kinase 0.467306
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.460883
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.460506
ZNF222 zinc finger protein 222 0.459373
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.45447
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.449194
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 0.437154
INS insulin 0.434899
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.43227
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.431144
MEN1 multiple endocrine neoplasia I 0.391513
CRH corticotropin releasing hormone 0.388166
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.383708
TRHR thyrotropin-releasing hormone receptor 0.362978
CYTL1 cytokine-like 1 0.35892
STAR steroidogenic acute regulatory protein 0.342006
NAGS N-acetylglutamate synthase 0.337975
DNASE1L3 deoxyribonuclease I-like 3 0.327375
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 0.324458
CLDN8 claudin 8 0.323002
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 0.322637
ARRB1 arrestin, beta 1 0.317545
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.315366
PDE11A phosphodiesterase 11A 0.313552
ALB albumin 0.306672
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.302698
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 0.269043
KNG1 kininogen 1 0.261599
SOX6 SRY (sex determining region Y)-box 6 0.253127
HAT1 histone acetyltransferase 1 0.245747
A4GALT alpha 1,4-galactosyltransferase 0.241196
GRM3 glutamate receptor, metabotropic 3 0.22937
ALDOB aldolase B, fructose-bisphosphate 0.211597
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.205916
GIPR gastric inhibitory polypeptide receptor 0.167224
SIX2 SIX homeobox 2 0.164786
OXT oxytocin/neurophysin I prepropeptide 0.163111
FGF23 fibroblast growth factor 23 0.161912
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.157929
ADRB2 adrenoceptor beta 2, surface 0.152887
POR P450 (cytochrome) oxidoreductase 0.144662
MLX MLX, MAX dimerization protein 0.142037