hyperhomocysteinemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood. (Human Disease Ontology, DOID_9279)
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Genes

193 genes co-occuring with the disease hyperhomocysteinemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 3.17168
CBS cystathionine-beta-synthase 2.64492
F5 coagulation factor V (proaccelerin, labile factor) 2.14737
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 2.04191
BHMT betaine--homocysteine S-methyltransferase 1.87653
PROS1 protein S (alpha) 1.76954
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.71909
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 1.6986
F2 coagulation factor II (thrombin) 1.68045
AHCY adenosylhomocysteinase 1.38472
CTH cystathionine gamma-lyase 1.31013
NOS3 nitric oxide synthase 3 (endothelial cell) 1.30226
MMD monocyte to macrophage differentiation-associated 1.29178
CRP C-reactive protein, pentraxin-related 1.16949
ALB albumin 1.14093
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 1.1367
CASR calcium-sensing receptor 1.12066
F8 coagulation factor VIII, procoagulant component 1.10931
GNMT glycine N-methyltransferase 1.08663
SOD2 superoxide dismutase 2, mitochondrial 1.06564
TIMP4 TIMP metallopeptidase inhibitor 4 1.03282
APOE apolipoprotein E 0.99908
PON1 paraoxonase 1 0.995705
TCN2 transcobalamin II 0.968341
PLG plasminogen 0.962053
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.957033
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.924626
MMP9 matrix metallopeptidase 9 0.898693
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.897872
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.894589
GPX1 glutathione peroxidase 1 0.864684
COMT catechol-O-methyltransferase 0.859771
CAT catalase 0.859362
TBCB tubulin folding cofactor B 0.838885
APOA1 apolipoprotein A-I 0.824128
BLMH bleomycin hydrolase 0.816745
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.813873
NNMT nicotinamide N-methyltransferase 0.800744
THBD thrombomodulin 0.800333
HDHD2 haloacid dehalogenase-like hydrolase domain containing 2 0.792541
PEMT phosphatidylethanolamine N-methyltransferase 0.779023
MARS methionyl-tRNA synthetase 0.770027
MMP2 matrix metallopeptidase 2 0.763086
LPA lipoprotein, Lp(a) 0.762678
VCAM1 vascular cell adhesion molecule 1 0.761047
APOB apolipoprotein B 0.759824
CCL2 chemokine (C-C motif) ligand 2 0.752898
INS insulin 0.733811
NCALD neurocalcin delta 0.725311
VWF von Willebrand factor 0.721673
GPX5 glutathione peroxidase 5 0.700321
GPX4 glutathione peroxidase 4 0.697109
BHMT2 betaine--homocysteine S-methyltransferase 2 0.689893
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.688692
CD320 CD320 molecule 0.671527
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.663975
F3 coagulation factor III (thromboplastin, tissue factor) 0.663578
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.66199
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.658818
TXN thioredoxin 0.656441
CYBA cytochrome b-245, alpha polypeptide 0.649323
TIMP1 TIMP metallopeptidase inhibitor 1 0.646559
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 0.644192
GIF gastric intrinsic factor (vitamin B synthesis) 0.62885
CBX1 chromobox homolog 1 0.607714
CST3 cystatin C 0.60147
PLAT plasminogen activator, tissue 0.592895
NOX4 NADPH oxidase 4 0.591337
GJA5 gap junction protein, alpha 5, 40kDa 0.580828
KNG1 kininogen 1 0.571884
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.564889
PPARG peroxisome proliferator-activated receptor gamma 0.562558
TTR transthyretin 0.561004
COG2 component of oligomeric golgi complex 2 0.547807
CSN1S1 casein alpha s1 0.543155
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 0.537731
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.534635
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.526904
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.521117
MPST mercaptopyruvate sulfurtransferase 0.51534
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.512648
ICAM1 intercellular adhesion molecule 1 0.51188
DDIT3 DNA-damage-inducible transcript 3 0.509576
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.497321
INMT indolethylamine N-methyltransferase 0.494266
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.482844
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d 0.472604
MAT1A methionine adenosyltransferase I, alpha 0.462394
ACE angiotensin I converting enzyme 0.458241
SELE selectin E 0.457864
DUOX1 dual oxidase 1 0.449947
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.441666
GLOD4 glyoxalase domain containing 4 0.441666
CHDH choline dehydrogenase 0.430017
DUOX2 dual oxidase 2 0.429642
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 0.423265
ENOSF1 enolase superfamily member 1 0.420266
SHD Src homology 2 domain containing transforming protein D 0.413527
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.411283
ANXA2 annexin A2 0.410161
LDHD lactate dehydrogenase D 0.406798
UNG uracil-DNA glycosylase 0.40008
EDN1 endothelin 1 0.399707
NT5E 5'-nucleotidase, ecto (CD73) 0.398962
FEV FEV (ETS oncogene family) 0.381852
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.378885
RPS3A ribosomal protein S3A 0.376661
LOX lysyl oxidase 0.375179
PRDX2 peroxiredoxin 2 0.374438
COX5A cytochrome c oxidase subunit Va 0.365562
IL6 interleukin 6 0.362609
GAMT guanidinoacetate N-methyltransferase 0.361133
CYB5R2 cytochrome b5 reductase 2 0.360764
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.348614
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.345308
SREBF2 sterol regulatory element binding transcription factor 2 0.340906
MUT methylmalonyl CoA mutase 0.340173
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 0.338341
HRG histidine-rich glycoprotein 0.336876
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 0.335046
WDR1 WD repeat domain 1 0.334315
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.328834
GCLC glutamate-cysteine ligase, catalytic subunit 0.327375
BGLAP bone gamma-carboxyglutamate (gla) protein 0.32373
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) 0.323002
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.320817
AK1 adenylate kinase 1 0.320454
TNF tumor necrosis factor 0.32009
GRM5 glutamate receptor, metabotropic 5 0.318635
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.313552
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 0.31029
PDHB pyruvate dehydrogenase (lipoamide) beta 0.30848
CDH5 cadherin 5, type 2 (vascular endothelium) 0.305948
SOAT2 sterol O-acyltransferase 2 0.301976
TJP1 tight junction protein 1 0.301254
XBP1 X-box binding protein 1 0.301254
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.300173
PSEN1 presenilin 1 0.295492
TYMS thymidylate synthetase 0.285444
NRGN neurogranin (protein kinase C substrate, RC3) 0.280439
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.274376
CPB2 carboxypeptidase B2 (plasma) 0.272241
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.270819
ATF6 activating transcription factor 6 0.265494
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.26266
PCBP1 poly(rC) binding protein 1 0.260891
BCHE butyrylcholinesterase 0.259477
OR3A1 olfactory receptor, family 3, subfamily A, member 1 0.259124
JUN jun proto-oncogene 0.259124
FOLR1 folate receptor 1 (adult) 0.248203
STMN1 stathmin 1 0.248203
NOS2 nitric oxide synthase 2, inducible 0.244696
COPB1 coatomer protein complex, subunit beta 1 0.243295
GJA1 gap junction protein, alpha 1, 43kDa 0.241196
SREBF1 sterol regulatory element binding transcription factor 1 0.240497
BEND3 BEN domain containing 3 0.238054
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.236312
C12ORF57 chromosome 12 open reading frame 57 0.235268
LASP1 LIM and SH3 protein 1 0.227297
XPO4 exportin 4 0.218034
ANXA5 annexin A5 0.218034
FADS2 fatty acid desaturase 2 0.217012
GSR glutathione reductase 0.211597
TGFB1 transforming growth factor, beta 1 0.211597
CXCL8 chemokine (C-X-C motif) ligand 8 0.211261
BACE1 beta-site APP-cleaving enzyme 1 0.209583
BBS9 Bardet-Biedl syndrome 9 0.209248
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.207245
S100B S100 calcium binding protein B 0.204923
ACHE acetylcholinesterase (Yt blood group) 0.204923
TIMP3 TIMP metallopeptidase inhibitor 3 0.204263
HCFC1 host cell factor C1 0.203604
CARD17 caspase recruitment domain family, member 17 0.198064
OCLN occludin 0.196779
DRAM1 DNA-damage regulated autophagy modulator 1 0.196459
SYCP3 synaptonemal complex protein 3 0.191097
SLC46A1 solute carrier family 46 (folate transporter), member 1 0.190168
EPHB4 EPH receptor B4 0.189859
VEGFA vascular endothelial growth factor A 0.180937
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.179802
PSPH phosphoserine phosphatase 0.175146
SYN1 synapsin I 0.173832
NLRP3 NLR family, pyrin domain containing 3 0.170054
FDXR ferredoxin reductase 0.166768
ARHGAP35 Rho GTPase activating protein 35 0.165435
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.163317
ICMT isoprenylcysteine carboxyl methyltransferase 0.163317
PON2 paraoxonase 2 0.162109
IGLV2-14 immunoglobulin lambda variable 2-14 0.161139
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.160948
IL18 interleukin 18 0.160761
ATP11A ATPase, class VI, type 11A 0.160387
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.15948