hyperopia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

310 genes co-occuring with the disease hyperopia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
KIF21A kinesin family member 21A 2.1935
PHOX2A paired-like homeobox 2a 2.02748
MFRP membrane frizzled-related protein 1.87561
CHN1 chimerin 1 1.76999
DPT dermatopontin 1.62739
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 1.59876
VANGL2 VANGL planar cell polarity protein 2 1.54363
IFITM2 interferon induced transmembrane protein 2 1.53216
LMLN leishmanolysin-like (metallopeptidase M8 family) 1.46539
HOXA1 homeobox A1 1.41709
DSE dermatan sulfate epimerase 1.41052
VANGL1 VANGL planar cell polarity protein 1 1.39302
DDT D-dopachrome tautomerase 1.3433
MATK megakaryocyte-associated tyrosine kinase 1.30488
SALL4 spalt-like transcription factor 4 1.23516
NOG noggin 1.19921
CLVS1 clavesin 1 1.18539
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 1.18238
CMSS1 cms1 ribosomal small subunit homolog (yeast) 1.13839
NKD2 naked cuticle homolog 2 (Drosophila) 1.13543
FRMD7 FERM domain containing 7 1.12867
FZD6 frizzled class receptor 6 1.08327
PRICKLE2 prickle homolog 2 (Drosophila) 1.07656
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) 1.05807
PRELID1 PRELI domain containing 1 1.05639
NYX nyctalopin 1.0383
NKD1 naked cuticle homolog 1 (Drosophila) 0.991065
ZNF692 zinc finger protein 692 0.990644
EBP emopamil binding protein (sterol isomerase) 0.97044
TMEM98 transmembrane protein 98 0.95745
WNT11 wingless-type MMTV integration site family, member 11 0.952021
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 0.944106
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 0.918848
MBD5 methyl-CpG binding domain protein 5 0.913492
LCK LCK proto-oncogene, Src family tyrosine kinase 0.911022
OR2B2 olfactory receptor, family 2, subfamily B, member 2 0.887208
ADAL adenosine deaminase-like 0.88475
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.870415
ADGRG1 adhesion G protein-coupled receptor G1 0.853631
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.851583
PTCH1 patched 1 0.843802
AMTN amelotin 0.840525
KERA keratocan 0.822488
GREM2 gremlin 2, DAN family BMP antagonist 0.782298
GJD2 gap junction protein, delta 2, 36kDa 0.781888
EARS2 glutamyl-tRNA synthetase 2, mitochondrial 0.776977
NMS neuromedin S 0.776159
ZNRF3 zinc and ring finger 3 0.766759
PPT1 palmitoyl-protein thioesterase 1 0.765127
EPYC epiphycan 0.756156
ANKRD6 ankyrin repeat domain 6 0.745172
CASQ2 calsequestrin 2 (cardiac muscle) 0.741923
GLRB glycine receptor, beta 0.731786
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 0.727738
ZC3H13 zinc finger CCCH-type containing 13 0.72127
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 0.720058
FUS FUS RNA binding protein 0.704742
LAMA3 laminin, alpha 3 0.699116
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.687491
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.682294
VSX2 visual system homeobox 2 0.681495
SURF1 surfeit 1 0.659611
SCRIB scribbled planar cell polarity protein 0.653276
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 0.647743
C19ORF26 chromosome 19 open reading frame 26 0.644981
FMN1 formin 1 0.643404
NLK nemo-like kinase 0.639463
FGF13 fibroblast growth factor 13 0.638676
DUSP22 dual specificity phosphatase 22 0.635921
BMP2K BMP2 inducible kinase 0.631991
DAAM2 dishevelled associated activator of morphogenesis 2 0.631205
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.630813
UBE2A ubiquitin-conjugating enzyme E2A 0.622575
FBLIM1 filamin binding LIM protein 1 0.6214
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 0.613574
ECEL1 endothelin converting enzyme-like 1 0.610448
PDLIM1 PDZ and LIM domain 1 0.605762
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 0.60108
OVGP1 oviductal glycoprotein 1, 120kDa 0.59874
EFNB1 ephrin-B1 0.597961
PMM2 phosphomannomutase 2 0.590948
FOXF2 forkhead box F2 0.588222
PRICKLE1 prickle homolog 1 (Drosophila) 0.587054
RP2 retinitis pigmentosa 2 (X-linked recessive) 0.584719
FOXC2 forkhead box C2 0.571884
WDFY2 WD repeat and FYVE domain containing 2 0.561392
CHD7 chromodomain helicase DNA binding protein 7 0.560616
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 0.55945
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.554403
LCA5 Leber congenital amaurosis 5 0.551298
RAB2A RAB2A, member RAS oncogene family 0.549747
FZD3 frizzled class receptor 3 0.548971
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 0.546644
VIPR2 vasoactive intestinal peptide receptor 2 0.542767
HOXB1 homeobox B1 0.541217
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.539667
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.53657
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.534248
FGF17 fibroblast growth factor 17 0.526904
DAAM1 dishevelled associated activator of morphogenesis 1 0.526518
CRYBA4 crystallin, beta A4 0.524588
CRLF1 cytokine receptor-like factor 1 0.521502
PER1 period circadian clock 1 0.517649
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.51534
FOXQ1 forkhead box Q1 0.514186
FRZB frizzled-related protein 0.511112
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.507657
COPA coatomer protein complex, subunit alpha 0.507657
NBPF1 neuroblastoma breakpoint family, member 1 0.496175
FOXC1 forkhead box C1 0.489691
EFNB3 ephrin-B3 0.482464
FOXL2 forkhead box L2 0.474877
WNT5B wingless-type MMTV integration site family, member 5B 0.474119
CYCS cytochrome c, somatic 0.471089
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.468063
DVL3 dishevelled segment polarity protein 3 0.465794
BMP8B bone morphogenetic protein 8b 0.465416
PITX2 paired-like homeodomain 2 0.463527
EVC2 Ellis van Creveld syndrome 2 0.460506
RAI1 retinoic acid induced 1 0.460506
CTSC cathepsin C 0.457109
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.454847
CCDC27 coiled-coil domain containing 27 0.453716
CHRND cholinergic receptor, nicotinic, delta (muscle) 0.451454
AMBN ameloblastin (enamel matrix protein) 0.449571
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) 0.447311
SPAG7 sperm associated antigen 7 0.444676
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.43941
ALK anaplastic lymphoma receptor tyrosine kinase 0.438282
RAB2B RAB2B, member RAS oncogene family 0.426265
OSTM1 osteopetrosis associated transmembrane protein 1 0.425514
KARS lysyl-tRNA synthetase 0.425514
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 0.424389
PCDH11Y protocadherin 11 Y-linked 0.421765
COL9A1 collagen, type IX, alpha 1 0.419517
FXR2 fragile X mental retardation, autosomal homolog 2 0.419142
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.415773
MTM1 myotubularin 1 0.412405
ACTC1 actin, alpha, cardiac muscle 1 0.406425
BEST1 bestrophin 1 0.405678
SIM2 single-minded family bHLH transcription factor 2 0.403064
WNT5A wingless-type MMTV integration site family, member 5A 0.401199
DVL2 dishevelled segment polarity protein 2 0.398216
TRDN triadin 0.395235
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.394118
HES4 hes family bHLH transcription factor 4 0.394118
AXL AXL receptor tyrosine kinase 0.393001
FUT2 fucosyltransferase 2 (secretor status included) 0.388909
WNT3 wingless-type MMTV integration site family, member 3 0.387051
PRKCZ protein kinase C, zeta 0.383708
CRYBB1 crystallin, beta B1 0.382966
PCDH11X protocadherin 11 X-linked 0.377773
LSR lipolysis stimulated lipoprotein receptor 0.372217
DLG1 discs, large homolog 1 (Drosophila) 0.371847
CLCN6 chloride channel, voltage-sensitive 6 0.369628
CUTA cutA divalent cation tolerance homolog (E. coli) 0.366301
MCM8 minichromosome maintenance complex component 8 0.361133
TGFBR3 transforming growth factor, beta receptor III 0.358183
CFAP74 cilia and flagella associated protein 74 0.35082
TBCE tubulin folding cofactor E 0.340539
HRK harakiri, BCL2 interacting protein 0.340173
MON1A MON1 secretory trafficking family member A 0.33944
SDCBP syndecan binding protein (syntenin) 0.33944
TGFBI transforming growth factor, beta-induced, 68kDa 0.338707
NOTCH1 notch 1 0.337975
OSCAR osteoclast associated, immunoglobulin-like receptor 0.333583
CLCN7 chloride channel, voltage-sensitive 7 0.332121
ZIC2 Zic family member 2 0.331391
RORA RAR-related orphan receptor A 0.329565
LARS leucyl-tRNA synthetase 0.325916
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.325187
RSPO1 R-spondin 1 0.32373
EVC Ellis van Creveld protein 0.318635
NUMA1 nuclear mitotic apparatus protein 1 0.317909
RS1 retinoschisin 1 0.313915
GADD45G growth arrest and DNA-damage-inducible, gamma 0.313189
CDKN2A cyclin-dependent kinase inhibitor 2A 0.309204
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 0.304142
PEX19 peroxisomal biogenesis factor 19 0.300894
FGFR2 fibroblast growth factor receptor 2 0.299452
TYR tyrosinase 0.297291
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.295492
SETX senataxin 0.295132
CUL1 cullin 1 0.292257
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.290103
FYB FYN binding protein 0.289744
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 0.289744
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.285086
SDC4 syndecan 4 0.285086
CPSF3L cleavage and polyadenylation specific factor 3-like 0.281868
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 0.27794
OMG oligodendrocyte myelin glycoprotein 0.277584
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 0.276158
MYDGF myeloid-derived growth factor 0.275089
PTK7 protein tyrosine kinase 7 (inactive) 0.274732
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 0.274021
MITF microphthalmia-associated transcription factor 0.271174
DVL1 dishevelled segment polarity protein 1 0.264077
HTN3 histatin 3 0.261952
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.25877
THBS2 thrombospondin 2 0.257711
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.256299
ERBB4 erb-b2 receptor tyrosine kinase 4 0.254183
VSX1 visual system homeobox 1 0.253479
YARS tyrosyl-tRNA synthetase 0.253479
JMJD6 jumonji domain containing 6 0.249608
CA8 carbonic anhydrase VIII 0.246448
STAT2 signal transducer and activator of transcription 2, 113kDa 0.237706
PAX6 paired box 6 0.237009
COL11A1 collagen, type XI, alpha 1 0.237009
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.236312
EREG epiregulin 0.230409
FZD4 frizzled class receptor 4 0.226952
MERTK MER proto-oncogene, tyrosine kinase 0.225917
TTPA tocopherol (alpha) transfer protein 0.222822
PANK2 pantothenate kinase 2 0.221793
ENAM enamelin 0.220424
SOX2 SRY (sex determining region Y)-box 2 0.216332
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.216332
MAP2K4 mitogen-activated protein kinase kinase 4 0.215992
NRL neural retina leucine zipper 0.214975
HEXA hexosaminidase A (alpha polypeptide) 0.212271
CEP290 centrosomal protein 290kDa 0.210589
CLCN1 chloride channel, voltage-sensitive 1 0.208914
NPR1 natriuretic peptide receptor 1 0.208579
DAND5 DAN domain family member 5, BMP antagonist 0.208579
GUCY2C guanylate cyclase 2C 0.207912
SIX3 SIX homeobox 3 0.207578
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 0.202618
OCA2 oculocutaneous albinism II 0.197742
LMX1B LIM homeobox transcription factor 1, beta 0.196139
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.19582
OPRM1 opioid receptor, mu 1 0.190476
CNTN2 contactin 2 (axonal) 0.189244
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.189244
GK glycerol kinase 0.18472
EFNB2 ephrin-B2 0.184424
SARS seryl-tRNA synthetase 0.181798
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.178126
BTC betacellulin 0.176215
HNF4A hepatocyte nuclear factor 4, alpha 0.171036
WIPF2 WAS/WASL interacting protein family, member 2 0.169812
LMNB1 lamin B1 0.167452
FGFR3 fibroblast growth factor receptor 3 0.163729
TYRP1 tyrosinase-related protein 1 0.162505
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.160948
NCSTN nicastrin 0.158097
PRSS21 protease, serine, 21 (testisin) 0.130911
PRL prolactin 0.130505
BSG basigin (Ok blood group) 0.129797
LAX1 lymphocyte transmembrane adaptor 1 0.129181
CXCR5 chemokine (C-X-C motif) receptor 5 0.126021
UBE2S ubiquitin-conjugating enzyme E2S 0.122836
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.121649
UBE2K ubiquitin-conjugating enzyme E2K 0.120322
EP300 E1A binding protein p300 0.118132
F3 coagulation factor III (thromboplastin, tissue factor) 0.117552
GLO1 glyoxalase I 0.116762
FGF8 fibroblast growth factor 8 (androgen-induced) 0.116691
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.115057
TBP TATA box binding protein 0.11287
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.112541
HEXB hexosaminidase B (beta polypeptide) 0.111727
CADM1 cell adhesion molecule 1 0.111083
IDS iduronate 2-sulfatase 0.110979
FGF19 fibroblast growth factor 19 0.110944
FN1 fibronectin 1 0.109838
ATP7B ATPase, Cu++ transporting, beta polypeptide 0.109263
PIDD1 p53-induced death domain protein 1 0.108715
HCRT hypocretin (orexin) neuropeptide precursor 0.108696
MBP myelin basic protein 0.10714
TPH1 tryptophan hydroxylase 1 0.106617
AQP4 aquaporin 4 0.09625
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 0.095866
TTR transthyretin 0.094588
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.094515
PLAT plasminogen activator, tissue 0.093436
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.092513
PSEN1 presenilin 1 0.089658
LRP2 low density lipoprotein receptor-related protein 2 0.087161
PTER phosphotriesterase related 0.087081
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.086974
MNX1 motor neuron and pancreas homeobox 1 0.086038
IFNB1 interferon, beta 1, fibroblast 0.085795
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.085281
DMPK dystrophia myotonica-protein kinase 0.0852
TF transferrin 0.085092
CREBBP CREB binding protein 0.084521
AREG amphiregulin 0.084466
NF1 neurofibromin 1 0.083205
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.082483
COL2A1 collagen, type II, alpha 1 0.082456
PKD1P6 polycystic kidney disease 1 (autosomal dominant) pseudogene 6 0.08204
FOXP2 forkhead box P2 0.081984
BCHE butyrylcholinesterase 0.079058
ATXN3 ataxin 3 0.077889
F12 coagulation factor XII (Hageman factor) 0.076656
DNM2 dynamin 2 0.075818
CA2 carbonic anhydrase II 0.075501
ACAN aggrecan 0.075443
AXIN1 axin 1 0.074193
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.074135
FGF1 fibroblast growth factor 1 (acidic) 0.072702
OXA1L oxidase (cytochrome c) assembly 1-like 0.072263
SUMO2 small ubiquitin-like modifier 2 0.071498
ASPH aspartate beta-hydroxylase 0.070851
PPARA peroxisome proliferator-activated receptor alpha 0.070821
WNT3A wingless-type MMTV integration site family, member 3A 0.068455
CXCL12 chemokine (C-X-C motif) ligand 12 0.068366
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.068366