hyperostosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A bone remodeling disease that results in an abnormal growth of located_in bone. (Human Disease Ontology, DOID_205)
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Genes

205 genes co-occuring with the disease hyperostosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 2.77573
EXT2 exostosin glycosyltransferase 2 2.7441
SQSTM1 sequestosome 1 2.34065
SOST sclerostin 2.25001
ALPL alkaline phosphatase, liver/bone/kidney 2.13265
ALPPL2 alkaline phosphatase, placental-like 2 2.13165
ALPP alkaline phosphatase, placental 2.13115
CALCA calcitonin-related polypeptide alpha 1.98436
EXTL2 exostosin-like glycosyltransferase 2 1.82504
VCP valosin containing protein 1.76909
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 1.67277
LRP5 low density lipoprotein receptor-related protein 5 1.60279
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.53216
EXTL1 exostosin-like glycosyltransferase 1 1.48077
TRPS1 trichorhinophalangeal syndrome I 1.46759
BGLAP bone gamma-carboxyglutamate (gla) protein 1.39739
NUP205 nucleoporin 205kDa 1.18582
PTH parathyroid hormone 1.1524
COL6A1 collagen, type VI, alpha 1 1.14178
LRP6 low density lipoprotein receptor-related protein 6 1.08495
COL12A1 collagen, type XII, alpha 1 1.04293
FGF23 fibroblast growth factor 23 1.03662
OPTN optineurin 1.02187
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.993596
DCSTAMP dendrocyte expressed seven transmembrane protein 0.939534
CASC4 cancer susceptibility candidate 4 0.93207
EXTL3 exostosin-like glycosyltransferase 3 0.922561
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.870006
IHH indian hedgehog 0.862228
DMP1 dentin matrix acidic phosphoprotein 1 0.860999
MMP12 matrix metallopeptidase 12 0.831099
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) 0.826589
COL1A2 collagen, type I, alpha 2 0.820026
ANKH ANKH inorganic pyrophosphate transport regulator 0.807308
COL1A1 collagen, type I, alpha 1 0.800744
ASB12 ankyrin repeat and SOCS box containing 12 0.786803
CHPF chondroitin polymerizing factor 0.785984
UCMA upper zone of growth plate and cartilage matrix associated 0.783936
RIN3 Ras and Rab interactor 3 0.78066
MRAP melanocortin 2 receptor accessory protein 0.774523
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 0.774114
PHEX phosphate regulating endopeptidase homolog, X-linked 0.733811
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 0.733811
WDFY3 WD repeat and FYVE domain containing 3 0.732596
ACPP acid phosphatase, prostate 0.727738
TBC1D25 TBC1 domain family, member 25 0.715215
GOLGA6A golgin A6 family, member A 0.709572
GOLGA6B golgin A6 family, member B 0.709572
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.709169
IRS4 insulin receptor substrate 4 0.683892
BMP1 bone morphogenetic protein 1 0.677504
ACP5 acid phosphatase 5, tartrate resistant 0.648533
FAM20B family with sequence similarity 20, member B 0.647743
ETHE1 ethylmalonic encephalopathy 1 0.638676
MEF2C myocyte enhancer factor 2C 0.624535
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.612792
SCUBE3 signal peptide, CUB domain, EGF-like 3 0.610057
LPIN2 lipin 2 0.607323
SRP9 signal recognition particle 9kDa 0.6003
SRP9P1 signal recognition particle 9 pseudogene 1 0.6003
SDC2 syndecan 2 0.591337
FAXDC2 fatty acid hydroxylase domain containing 2 0.583552
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.567609
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 0.548195
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 0.547419
WNT1 wingless-type MMTV integration site family, member 1 0.536183
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.536183
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.527676
MEOX1 mesenchyme homeobox 1 0.525746
RHOT1 ras homolog family member T1 0.509959
GPHA2 glycoprotein hormone alpha 2 0.509576
LEMD3 LEM domain containing 3 0.503058
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.48893
ANKLE1 ankyrin repeat and LEM domain containing 1 0.484364
WNT3A wingless-type MMTV integration site family, member 3A 0.482464
A4GNT alpha-1,4-N-acetylglucosaminyltransferase 0.481325
IBSP integrin-binding sialoprotein 0.460506
KREMEN1 kringle containing transmembrane protein 1 0.460129
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.456355
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 0.450701
CTSK cathepsin K 0.448817
RAD21 RAD21 homolog (S. pombe) 0.446558
NOG noggin 0.434148
SP7 Sp7 transcription factor 0.427765
FDPS farnesyl diphosphate synthase 0.424765
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.42289
DCAF7 DDB1 and CUL4 associated factor 7 0.42214
TOM1 target of myb1 (chicken) 0.421765
SOSTDC1 sclerostin domain containing 1 0.388166
IL6 interleukin 6 0.386308
PRAMEF10 PRAME family member 10 0.382223
YIPF2 Yip1 domain family, member 2 0.379626
KL klotho 0.377402
RAD23A RAD23 homolog A (S. cerevisiae) 0.369628
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.351187
EIF3H eukaryotic translation initiation factor 3, subunit H 0.342372
KIN Kin17 DNA and RNA binding protein 0.339073
FLNA filamin A, alpha 0.333583
SFRP4 secreted frizzled-related protein 4 0.324823
TBK1 TANK-binding kinase 1 0.322637
PTDSS1 phosphatidylserine synthase 1 0.294053
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 0.290821
MUCL1 mucin-like 1 0.285444
NCOA1 nuclear receptor coactivator 1 0.280796
RUNX2 runt-related transcription factor 2 0.279011
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.278654
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.276514
MRO maestro 0.270108
KRTAP1-3 keratin associated protein 1-3 0.269398
KRTAP1-1 keratin associated protein 1-1 0.269398
TGFB1 transforming growth factor, beta 1 0.261245
EMP1 epithelial membrane protein 1 0.258064
C1ORF174 chromosome 1 open reading frame 174 0.257711
HSF2 heat shock transcription factor 2 0.257358
SDC3 syndecan 3 0.253127
TBCA tubulin folding cofactor A 0.243645
BMP7 bone morphogenetic protein 7 0.243295
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.233878
HAPLN1 hyaluronan and proteoglycan link protein 1 0.227297
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.22454
ONECUT3 one cut homeobox 3 0.222136
CALCR calcitonin receptor 0.220081
TNF tumor necrosis factor 0.218374
PEBP1 phosphatidylethanolamine binding protein 1 0.218374
CHRD chordin 0.217693
FGF8 fibroblast growth factor 8 (androgen-induced) 0.216332
BMP6 bone morphogenetic protein 6 0.212271
GLI3 GLI family zinc finger 3 0.208245
CTSC cathepsin C 0.198386
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.195501
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 0.187415
CRTAP cartilage associated protein 0.184424
BMP4 bone morphogenetic protein 4 0.181798
HSF4 heat shock transcription factor 4 0.181222
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.180937
CRP C-reactive protein, pentraxin-related 0.180652
P3H1 prolyl 3-hydroxylase 1 0.176485
PTER phosphotriesterase related 0.174354
OSTM1 osteopetrosis associated transmembrane protein 1 0.173571
AMER1 APC membrane recruitment protein 1 0.173314
WNT7B wingless-type MMTV integration site family, member 7B 0.171286
ANXA13 annexin A13 0.171286
LRP4 low density lipoprotein receptor-related protein 4 0.167452
PTHLH parathyroid hormone-like hormone 0.162505
MAPK11 mitogen-activated protein kinase 11 0.162505
PARD6A par-6 family cell polarity regulator alpha 0.162109
ALX4 ALX homeobox 4 0.161716
A4GALT alpha 1,4-galactosyltransferase 0.161139
GH2 growth hormone 2 0.160761
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.157765
HAS3 hyaluronan synthase 3 0.143064
HAS2 hyaluronan synthase 2 0.141702
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.141635
CSMD3 CUB and Sushi multiple domains 3 0.14142
GPC1 glypican 1 0.141282
RFXANK regulatory factor X-associated ankyrin-containing protein 0.140671
WNT11 wingless-type MMTV integration site family, member 11 0.140607
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.139832
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.139798
SCAI suppressor of cancer cell invasion 0.139557
FES FES proto-oncogene, tyrosine kinase 0.139085
TRAF3 TNF receptor-associated factor 3 0.136723
HNMT histamine N-methyltransferase 0.135423
SHH sonic hedgehog 0.133111
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.133007
MEF2A myocyte enhancer factor 2A 0.131011
DOK7 docking protein 7 0.130775
ADAM28 ADAM metallopeptidase domain 28 0.130717
DLX5 distal-less homeobox 5 0.129616
YIPF1 Yip1 domain family, member 1 0.129296
RAPSN receptor-associated protein of the synapse 0.128843
GREM1 gremlin 1, DAN family BMP antagonist 0.128758
HAS1 hyaluronan synthase 1 0.128018
LOXL2 lysyl oxidase-like 2 0.127136
MYEF2 myelin expression factor 2 0.126245
NT5C2 5'-nucleotidase, cytosolic II 0.125831
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.125653
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.125167
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.12391
GREM2 gremlin 2, DAN family BMP antagonist 0.123305
LDLR low density lipoprotein receptor 0.122399
FGF9 fibroblast growth factor 9 0.121101
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 0.121032
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.119389
MSX2 msh homeobox 2 0.118724
AXIN2 axin 2 0.11833
CXADR coxsackie virus and adenovirus receptor 0.117689
TG thyroglobulin 0.117443
HHAT hedgehog acyltransferase 0.116149
LEF1 lymphoid enhancer-binding factor 1 0.114907
FGFR3 fibroblast growth factor receptor 3 0.114046
KEAP1 kelch-like ECH-associated protein 1 0.108235
MYO6 myosin VI 0.107784
AHSG alpha-2-HS-glycoprotein 0.107481
LGALS8 lectin, galactoside-binding, soluble, 8 0.105656
IL6ST interleukin 6 signal transducer 0.105296
CARD17 caspase recruitment domain family, member 17 0.10219
HPSE heparanase 0.100624
SOX9 SRY (sex determining region Y)-box 9 0.098143
PDHX pyruvate dehydrogenase complex, component X 0.098004
MUSK muscle, skeletal, receptor tyrosine kinase 0.097912
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.097309
COL4A5 collagen, type IV, alpha 5 0.097026
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.096791
GCG glucagon 0.096131