hypertension Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. (Experimental Factor Ontology, EFO_0000537)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0000822
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Genes

341 genes associated with the hypertension phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
ZFAT zinc finger and AT hook domain containing 2.49937
NOS3 nitric oxide synthase 3 (endothelial cell) 1.75912
PRKCE protein kinase C, epsilon 1.72215
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 1.70448
HK1 hexokinase 1 1.63258
TMPRSS6 transmembrane protease, serine 6 1.61591
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.48419
UMOD uromodulin 1.46277
ARHGAP42 Rho GTPase activating protein 42 1.45654
BAG6 BCL2-associated athanogene 6 1.43716
LPL lipoprotein lipase 1.43716
GPR39 G protein-coupled receptor 39 1.43716
HFE hemochromatosis 1.41863
MYO6 myosin VI 1.40061
GCKR glucokinase (hexokinase 4) regulator 1.40061
TFR2 transferrin receptor 2 1.38847
BUD13 BUD13 homolog (S. cerevisiae) 1.30781
MACROD2 MACRO domain containing 2 1.26545
NELL1 NEL-like 1 (chicken) 1.26545
PLCE1 phospholipase C, epsilon 1 1.25251
PAX5 paired box 5 1.25251
LRRC7 leucine rich repeat containing 7 1.19958
APOA5 apolipoprotein A-V 1.18704
FCRL1 Fc receptor-like 1 1.17957
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 1.17192
NELFCD negative elongation factor complex member C/D 1.17192
PRKCA protein kinase C, alpha 1.17174
VTA1 vesicle (multivesicular body) trafficking 1 1.15352
ZNF618 zinc finger protein 618 1.14655
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.12851
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 1.12851
NFIB nuclear factor I/B 1.12456
PIEZO2 piezo-type mechanosensitive ion channel component 2 1.11203
GSTCD glutathione S-transferase, C-terminal domain containing 1.08797
SLC39A8 solute carrier family 39 (zinc transporter), member 8 1.08774
MEF2C myocyte enhancer factor 2C 1.08774
FES FES proto-oncogene, tyrosine kinase 1.0674
NLGN1 neuroligin 1 1.06676
ASPG asparaginase 1.06211
AGBL1 ATP/GTP binding protein-like 1 1.05869
GDF3 growth differentiation factor 3 1.05616
PLG plasminogen 1.0543
LOC339529 uncharacterized LOC339529 1.04365
ARHGAP29 Rho GTPase activating protein 29 1.04365
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 1.02868
CCAR1 cell division cycle and apoptosis regulator 1 1.02549
ALX4 ALX homeobox 4 1.01962
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 1.01768
RORA RAR-related orphan receptor A 1.00952
MYH11 myosin, heavy chain 11, smooth muscle 1.00059
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 1.00059
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 1.00059
SEC31B SEC31 homolog B (S. cerevisiae) 1.00059
GPC6 glypican 6 1.00059
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.999507
SDCBP2 syndecan binding protein (syntenin) 2 0.994551
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.988702
UNC5CL unc-5 homolog C (C. elegans)-like 0.98364
CNTN4 contactin 4 0.971944
TMC6 transmembrane channel-like 6 0.969142
CNTNAP5 contactin associated protein-like 5 0.969142
AK5 adenylate kinase 5 0.962749
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.952117
MPPED2 metallophosphoesterase domain containing 2 0.951856
WWC1 WW and C2 domain containing 1 0.948789
EYA2 EYA transcriptional coactivator and phosphatase 2 0.947546
KDM4A lysine (K)-specific demethylase 4A 0.942765
SLC35F1 solute carrier family 35, member F1 0.942765
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.942765
MSRA methionine sulfoxide reductase A 0.942765
MPZL3 myelin protein zero-like 3 0.942765
FMN2 formin 2 0.942765
ARMC9 armadillo repeat containing 9 0.942765
TNR tenascin R 0.942765
MIPEPP3 mitochondrial intermediate peptidase pseudogene 3 0.942765
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.942765
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.935362
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.929444
LOC643339 uncharacterized LOC643339 0.928309
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.926745
CHD2 chromodomain helicase DNA binding protein 2 0.925427
PCDH15 protocadherin-related 15 0.923276
ADAMTSL1 ADAMTS-like 1 0.922222
GPATCH2L G patch domain containing 2-like 0.922222
MYO1D myosin ID 0.919744
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.919744
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1 0.919744
COL8A1 collagen, type VIII, alpha 1 0.914846
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.914419
SYNE1 spectrin repeat containing, nuclear envelope 1 0.913994
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.911691
FCRL2 Fc receptor-like 2 0.906866
TRIM54 tripartite motif containing 54 0.901186
EFCAB11 EF-hand calcium binding domain 11 0.899912
YEATS4 YEATS domain containing 4 0.899912
ARRB1 arrestin, beta 1 0.899912
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.899731
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 0.891813
C8ORF34 chromosome 8 open reading frame 34 0.891649
BMPR1B bone morphogenetic protein receptor, type IB 0.882984
TSPO2 translocator protein 2 0.880922
THSD4 thrombospondin, type I, domain containing 4 0.880453
PACRG PARK2 co-regulated 0.879677
UBQLN1 ubiquilin 1 0.875451
EML5 echinoderm microtubule associated protein like 5 0.874717
FSTL4 follistatin-like 4 0.87156
ZNF221 zinc finger protein 221 0.869196
STOX2 storkhead box 2 0.868241
PHB prohibitin 0.868241
AGO2 argonaute RISC catalytic component 2 0.868241
EXOC4 exocyst complex component 4 0.868241
PHF10 PHD finger protein 10 0.868241
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.868241
C1ORF27 chromosome 1 open reading frame 27 0.868241
CNTN5 contactin 5 0.86743
MPV17 MpV17 mitochondrial inner membrane protein 0.866229
JAZF1 JAZF zinc finger 1 0.859871
PKD1L1 polycystic kidney disease 1 like 1 0.85593
ADAM12 ADAM metallopeptidase domain 12 0.855449
SLC39A11 solute carrier family 39, member 11 0.855449
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.851243
PLCB4 phospholipase C, beta 4 0.849438
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 0.849327
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.849215
WDR4 WD repeat domain 4 0.845725
NPAS2 neuronal PAS domain protein 2 0.840142
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.839148
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 0.838165
TF transferrin 0.824663
COL23A1 collagen, type XXIII, alpha 1 0.823019
PRKG1 protein kinase, cGMP-dependent, type I 0.81905
CD276 CD276 molecule 0.817516
PVT1 Pvt1 oncogene (non-protein coding) 0.817516
SERGEF secretion regulating guanine nucleotide exchange factor 0.810722
IDNK idnK, gluconokinase homolog (E. coli) 0.810722
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.802966
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.800318
COL4A1 collagen, type IV, alpha 1 0.797753
RHOBTB2 Rho-related BTB domain containing 2 0.797753
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.7965
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.7965
INTS12 integrator complex subunit 12 0.794052
CCDC180 coiled-coil domain containing 180 0.790435
FRMD4A FERM domain containing 4A 0.790435
ADD2 adducin 2 (beta) 0.790435
UNQ6494 uncharacterized LOC100129066 0.790435
CHN2 chimerin 2 0.786
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.784165
TP63 tumor protein p63 0.784165
DNAH5 dynein, axonemal, heavy chain 5 0.782369
MIR1-1HG MIR1-1 host gene 0.781779
UNC13C unc-13 homolog C (C. elegans) 0.779456
HOTTIP HOXA distal transcript antisense RNA 0.772313
HPCAL1 hippocalcin-like 1 0.771787
GAB1 GRB2-associated binding protein 1 0.770746
MAPK10 mitogen-activated protein kinase 10 0.768197
SLIT3 slit homolog 3 (Drosophila) 0.766212
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.762996
FRMD6 FERM domain containing 6 0.756753
ETV6 ets variant 6 0.756252
C9ORF129 chromosome 9 open reading frame 129 0.753299
LARGE like-glycosyltransferase 0.751382
SEPT9 septin 9 0.751382
CHODL chondrolectin 0.750439
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.747212
DPYD dihydropyrimidine dehydrogenase 0.745419
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.743226
CD163L1 CD163 molecule-like 1 0.740664
CYLD cylindromatosis (turban tumor syndrome) 0.739411
COL28A1 collagen, type XXVIII, alpha 1 0.735423
FTO fat mass and obesity associated 0.735423
ANO2 anoctamin 2, calcium activated chloride channel 0.734535
GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 0.730636
TSSC1 tumor suppressing subtransferable candidate 1 0.730213
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.728954
CCSER1 coiled-coil serine-rich protein 1 0.728123
THSD7A thrombospondin, type I, domain containing 7A 0.7273
PHTF2 putative homeodomain transcription factor 2 0.722896
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 0.717942
RGS7 regulator of G-protein signaling 7 0.717203
LEKR1 leucine, glutamate and lysine rich 1 0.712186
NTN1 netrin 1 0.710458
PTPRD protein tyrosine phosphatase, receptor type, D 0.707893
ING3 inhibitor of growth family, member 3 0.707523
SOX5 SRY (sex determining region Y)-box 5 0.706786
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K 0.706055
C15ORF41 chromosome 15 open reading frame 41 0.704251
CSF3R colony stimulating factor 3 receptor (granulocyte) 0.703894
CROT carnitine O-octanoyltransferase 0.701084
ATRAID all-trans retinoic acid-induced differentiation factor 0.700393
CELF5 CUGBP, Elav-like family member 5 0.69768
MSI2 musashi RNA-binding protein 2 0.69768
LOC285000 uncharacterized LOC285000 0.696681
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.694067
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.692152
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.689656
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.686922
TMX4 thioredoxin-related transmembrane protein 4 0.685437
FSCN1 fascin actin-bundling protein 1 0.684849
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.683107
LHFPL3 lipoma HMGIC fusion partner-like 3 0.682533
CWC22 CWC22 spliceosome-associated protein 0.681679
MRGPRE MAS-related GPR, member E 0.681114
MYT1L myelin transcription factor 1-like 0.677522
BRSK2 BR serine/threonine kinase 2 0.677522
SLC22A23 solute carrier family 22, member 23 0.676616
SAMD12 sterile alpha motif domain containing 12 0.675124
ACOXL acyl-CoA oxidase-like 0.675124
MALRD1 MAM and LDL receptor class A domain containing 1 0.674532
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.674238
BEAN1 brain expressed, associated with NEDD4, 1 0.672779
DPCR1 diffuse panbronchiolitis critical region 1 0.671914
PALLD palladin, cytoskeletal associated protein 0.671627
VCAN versican 0.670772
PBX3 pre-B-cell leukemia homeobox 3 0.669923
EXT2 exostosin glycosyltransferase 2 0.669362
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.665784
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.66233
KIAA2018 KIAA2018 0.661809
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.661549
EMX2OS EMX2 opposite strand/antisense RNA 0.660775
TSPYL6 TSPY-like 6 0.657736
ZBTB16 zinc finger and BTB domain containing 16 0.65699
RET ret proto-oncogene 0.656496
MATN2 matrilin 2 0.654787
PLA2G4E phospholipase A2, group IVE 0.654545
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 0.653823
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.653345
STK39 serine threonine kinase 39 0.652869
TRIM58 tripartite motif containing 58 0.652869
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 0.652631
CAMKMT calmodulin-lysine N-methyltransferase 0.651923
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.651688
NXPH2 neurexophilin 2 0.65006
FIP1L1 factor interacting with PAPOLA and CPSF1 0.649139
PRKD1 protein kinase D1 0.649139
CDH13 cadherin 13 0.640562
NRXN3 neurexin 3 0.639391
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.638004
SP4 Sp4 transcription factor 0.63709
ZNF26 zinc finger protein 26 0.636862
SRPRB signal recognition particle receptor, B subunit 0.635508
STARD13 StAR-related lipid transfer (START) domain containing 13 0.63373
C11ORF74 chromosome 11 open reading frame 74 0.63373
ANKRD55 ankyrin repeat domain 55 0.63329
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.633071
MYO3B myosin IIIB 0.631765
COL4A2 collagen, type IV, alpha 2 0.629625
MED12L mediator complex subunit 12-like 0.626496
RNF216 ring finger protein 216 0.625067
DNAH8 dynein, axonemal, heavy chain 8 0.624865
ZNF84 zinc finger protein 84 0.62426
MTMR2 myotubularin related protein 2 0.622467
ITGA1 integrin, alpha 1 0.622467
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.62168
LPP LIM domain containing preferred translocation partner in lipoma 0.620511
SPACA3 sperm acrosome associated 3 0.620318
ZNF891 zinc finger protein 891 0.620125
AKAP13 A kinase (PRKA) anchor protein 13 0.619356
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.618783
RAP1GAP2 RAP1 GTPase activating protein 2 0.618783
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.617271
DNAH9 dynein, axonemal, heavy chain 9 0.614969
CSMD1 CUB and Sushi multiple domains 1 0.614779
SHISA9 shisa family member 9 0.613833
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.612151
MARCH10 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase 0.611781
PRKG2 protein kinase, cGMP-dependent, type II 0.610862
SYK spleen tyrosine kinase 0.610497
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.610315
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.609589
MEF2BNB-MEF2B MEF2BNB-MEF2B readthrough 0.609408
SGSH N-sulfoglucosamine sulfohydrolase 0.60709
LOC644838 uncharacterized LOC644838 0.605862
MECOM MDS1 and EVI1 complex locus 0.60465
CCDC59 coiled-coil domain containing 59 0.604478
MYO10 myosin X 0.604306
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.603622
GALNS galactosamine (N-acetyl)-6-sulfatase 0.603452
FRMD4B FERM domain containing 4B 0.603282
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 0.602268
MCM10 minichromosome maintenance complex component 10 0.600931
WDR7 WD repeat domain 7 0.599285
NCKAP5 NCK-associated protein 5 0.596707
DOCK5 dedicator of cytokinesis 5 0.596548
ASTN2 astrotactin 2 0.596389
TSHZ2 teashirt zinc finger homeobox 2 0.594972
EXOC5 exocyst complex component 5 0.594038
FAM81B family with sequence similarity 81, member B 0.594038
GAPVD1 GTPase activating protein and VPS9 domains 1 0.594038
ZNRF3 zinc and ring finger 3 0.592807
ADAM19 ADAM metallopeptidase domain 19 0.592197
UTRN utrophin 0.591893
PARK2 parkin RBR E3 ubiquitin protein ligase 0.59159
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.591289
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.591138
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.588613
ZFR2 zinc finger RNA binding protein 2 0.587592
ANK2 ankyrin 2, neuronal 0.586438
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 0.585756
RAB3C RAB3C, member RAS oncogene family 0.584643
PEX5L peroxisomal biogenesis factor 5-like 0.584397
GPATCH2 G patch domain containing 2 0.58403
STRADA STE20-related kinase adaptor alpha 0.582458
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.582099
PHACTR2 phosphatase and actin regulator 2 0.581623
DOCK1 dedicator of cytokinesis 1 0.581623
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.581268
KALRN kalirin, RhoGEF kinase 0.581031
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.580444
METTL25 methyltransferase like 25 0.579976
SLC38A3 solute carrier family 38, member 3 0.579744
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.578589
CREB5 cAMP responsive element binding protein 5 0.578246
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.57745
GLRA3 glycine receptor, alpha 3 0.576886
SHB Src homology 2 domain containing adaptor protein B 0.576774
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.575991
ESRRB estrogen-related receptor beta 0.57588
TRAF1 TNF receptor-associated factor 1 0.573469
WSCD2 WSC domain containing 2 0.572823
NIPBL Nipped-B homolog (Drosophila) 0.571756
PDILT protein disulfide isomerase-like, testis expressed 0.571756
ERCC6L2 excision repair cross-complementation group 6-like 2 0.545725
FAM76B family with sequence similarity 76, member B 0.545725
C5ORF42 chromosome 5 open reading frame 42 0.524758
CEP57 centrosomal protein 57kDa 0.522995
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.500023
M6PR mannose-6-phosphate receptor (cation dependent) 0.498792
ZNF45 zinc finger protein 45 0.468945
CSMD3 CUB and Sushi multiple domains 3 0.463649
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.432155
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.408206
CLEC12B C-type lectin domain family 12, member B 0.406588
THRB thyroid hormone receptor, beta 0.40409
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.403073
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.401651
DSCAM Down syndrome cell adhesion molecule 0.400734
TMEM233 transmembrane protein 233 0.400089
SNX29 sorting nexin 29 0.396719
DRD2 dopamine receptor D2 0.395833