hypertension Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. (Experimental Factor Ontology, EFO_0000537)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000231
Similar Terms
Downloads & Tools

Genes

41 gene mutations causing the hypertension phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACE2 angiotensin I converting enzyme 2
ADD2 adducin 2 (beta)
AGXT2 alanine--glyoxylate aminotransferase 2
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CHGA chromogranin A
COMT catechol-O-methyltransferase
CORIN corin, serine peptidase
CRHR2 corticotropin releasing hormone receptor 2
CTH cystathionine gamma-lyase
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
DRD5 dopamine receptor D5
ELN elastin
FKBP1B FK506 binding protein 1B, 12.6 kDa
FSTL3 follistatin-like 3 (secreted glycoprotein)
GUCA2B guanylate cyclase activator 2B (uroguanylin)
HRAS Harvey rat sarcoma viral oncogene homolog
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IRS1 insulin receptor substrate 1
KCNK6 potassium channel, two pore domain subfamily K, member 6
KRAS Kirsten rat sarcoma viral oncogene homolog
MPV17 MpV17 mitochondrial inner membrane protein
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PDC phosducin
PNMT phenylethanolamine N-methyltransferase
PPARG peroxisome proliferator-activated receptor gamma
PRKG1 protein kinase, cGMP-dependent, type I
SCNN1B sodium channel, non voltage gated 1 beta subunit
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18
TAL1 T-cell acute lymphocytic leukemia 1
TLR5 toll-like receptor 5
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNK4 WNK lysine deficient protein kinase 4