hyperthyroidism Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A thyroid gland disease that involves an over production of thyroid hormone. (Human Disease Ontology, DOID_7998)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:7998
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Genes

58 genes associated with the disease hyperthyroidism in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
PDE8B phosphodiesterase 8B 2.39342
DIO1 deiodinase, iodothyronine, type I 2.30112
PDE10A phosphodiesterase 10A 2.1372
LHX3 LIM homeobox 3 1.77455
TSHR thyroid stimulating hormone receptor 1.67336
NFIA nuclear factor I/A 1.65612
FGF7 fibroblast growth factor 7 1.63837
C6ORF10 chromosome 6 open reading frame 10 1.62979
PRDM11 PR domain containing 11 1.57873
C1QTNF6 C1q and tumor necrosis factor related protein 6 1.55409
INSR insulin receptor 1.54533
SLAMF6 SLAM family member 6 1.49837
NRG1 neuregulin 1 1.47287
GLIS3 GLIS family zinc finger 3 1.37327
HLA-J major histocompatibility complex, class I, J (pseudogene) 1.35273
LPCAT2 lysophosphatidylcholine acyltransferase 2 1.34719
TCF19 transcription factor 19 1.31635
CCHCR1 coiled-coil alpha-helical rod protein 1 1.28962
MUC22 mucin 22 1.26694
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 1.26694
FCRL3 Fc receptor-like 3 1.24855
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 1.14463
TMEM196 transmembrane protein 196 1.07599
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 1.00407
MOG myelin oligodendrocyte glycoprotein 0.925042
CEP128 centrosomal protein 128kDa 0.882166
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.824682
TG thyroglobulin 0.682799
FCRL1 Fc receptor-like 1 0.662722
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.598832
TNF tumor necrosis factor 0.59062
FGFR1OP FGFR1 oncogene partner 0.570567
NELFE negative elongation factor complex member E 0.548806
SLA Src-like-adaptor 0.523095
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.497776
RNASET2 ribonuclease T2 0.495692
CD5L CD5 molecule-like 0.486808
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.484681
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.478563
FCRL2 Fc receptor-like 2 0.475515
CFB complement factor B 0.473946
CALD1 caldesmon 1 0.464876
LACTB lactamase, beta 0.458948
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.45529
VAV1 vav 1 guanine nucleotide exchange factor 0.45525
TASP1 taspase, threonine aspartase, 1 0.449656
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.448452
WISP1 WNT1 inducible signaling pathway protein 1 0.44652
STAC SH3 and cysteine rich domain 0.446439
RTKN2 rhotekin 2 0.44617
CSMD3 CUB and Sushi multiple domains 3 0.443379
RIN2 Ras and Rab interactor 2 0.441976
CNTNAP2 contactin associated protein-like 2 0.441823
KALRN kalirin, RhoGEF kinase 0.430502
RNF144A ring finger protein 144A 0.424383
CIPC CLOCK-interacting pacemaker 0.405313
ACSF3 acyl-CoA synthetase family member 3 0.404176
IRF2BPL interferon regulatory factor 2 binding protein-like 0.393344