hypertrophy Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Hypertrophy is the increase in the volume of an organ or tissue due to the enlargement of its component cells. (Experimental Factor Ontology, EFO_0002460)
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Genes

313 genes co-occuring with the biological term hypertrophy in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABRA actin binding Rho activating protein
ACAT1 acetyl-CoA acetyltransferase 1
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACTC1 actin, alpha, cardiac muscle 1
ADCY6 adenylate cyclase 6
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADRA1A adrenoceptor alpha 1A
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
ADRBK1 adrenergic, beta, receptor kinase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AGTRAP angiotensin II receptor-associated protein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALPL alkaline phosphatase, liver/bone/kidney
ANKH ANKH inorganic pyrophosphate transport regulator
ANXA2 annexin A2
APLN apelin
APLNR apelin receptor
APP amyloid beta (A4) precursor protein
AR androgen receptor
ATM ATM serine/threonine kinase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BCAR1 breast cancer anti-estrogen resistance 1
BCR breakpoint cluster region
BIRC5 baculoviral IAP repeat containing 5
BMP4 bone morphogenetic protein 4
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDV3 CDV3 homolog (mouse)
CHGA chromogranin A
CKMT1B creatine kinase, mitochondrial 1B
CLN3 ceroid-lipofuscinosis, neuronal 3
CMA1 chymase 1, mast cell
CMYA5 cardiomyopathy associated 5
CORIN corin, serine peptidase
CREG1 cellular repressor of E1A-stimulated genes 1
CRP C-reactive protein, pentraxin-related
CRTC1 CREB regulated transcription coactivator 1
CRTC2 CREB regulated transcription coactivator 2
CSF3 colony stimulating factor 3 (granulocyte)
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CST3 cystatin C
CTAG1B cancer/testis antigen 1B
CTF1 cardiotrophin 1
CTGF connective tissue growth factor
CTSL cathepsin L
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DCN decorin
DES desmin
DIO2 deiodinase, iodothyronine, type II
DMD dystrophin
DPP4 dipeptidyl-peptidase 4
E2F1 E2F transcription factor 1
EDN1 endothelin 1
EDNRA endothelin receptor type A
EGFR epidermal growth factor receptor
EIF4E eukaryotic translation initiation factor 4E
EMC7 ER membrane protein complex subunit 7
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EP300 E1A binding protein p300
EPO erythropoietin
ESR1 estrogen receptor 1
ESRRG estrogen-related receptor gamma
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXO32 F-box protein 32
FDPS farnesyl diphosphate synthase
FGF23 fibroblast growth factor 23
FKBP1B FK506 binding protein 1B, 12.6 kDa
FKBP4 FK506 binding protein 4, 59kDa
FKRP fukutin related protein
FLT1 fms-related tyrosine kinase 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GAB1 GRB2-associated binding protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GH1 growth hormone 1
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GIPR gastric inhibitory polypeptide receptor
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GREM1 gremlin 1, DAN family BMP antagonist
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
HBEGF heparin-binding EGF-like growth factor
HDAC2 histone deacetylase 2
HDAC4 histone deacetylase 4
HEXB hexosaminidase B (beta polypeptide)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGB1 high mobility group box 1
HOPX HOP homeobox
HRAS Harvey rat sarcoma viral oncogene homolog
HSPB8 heat shock 22kDa protein 8
HSPG2 heparan sulfate proteoglycan 2
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IFT81 intraflagellar transport 81
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2R insulin-like growth factor 2 receptor
IGFBP7 insulin-like growth factor binding protein 7
IHH indian hedgehog
IL13 interleukin 13
IL18 interleukin 18
IL1B interleukin 1, beta
IL6 interleukin 6
ILK integrin-linked kinase
IRS1 insulin receptor substrate 1
ISL1 ISL LIM homeobox 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JPH2 junctophilin 2
JUND jun D proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KLK3 kallikrein-related peptidase 3
LATS2 large tumor suppressor kinase 2
LEP leptin
LEPR leptin receptor
LPP LIM domain containing preferred translocation partner in lipoma
LRP5 low density lipoprotein receptor-related protein 5
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA1 melanoma antigen family A1
MAGEA3 melanoma antigen family A3
MAGEA4 melanoma antigen family A4
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MATN3 matrilin 3
MBL2 mannose-binding lectin (protein C) 2, soluble
MEF2A myocyte enhancer factor 2A
MEF2C myocyte enhancer factor 2C
MEF2D myocyte enhancer factor 2D
MIR150 microRNA 150
MIR155 microRNA 155
MIR200C microRNA 200c
MIR20A microRNA 20a
MIR21 microRNA 21
MIR212 microRNA 212
MIR214 microRNA 214
MIR26A1 microRNA 26a-1
MIR29A microRNA 29a
MIR499A microRNA 499a
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPZ myelin protein zero
MSTN myostatin
MT-TM tRNA
MT-TQ tRNA
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBPC3 myosin binding protein C, cardiac
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYOCD myocardin
MYOZ2 myozenin 2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NGF nerve growth factor (beta polypeptide)
NISCH nischarin
NMB neuromedin B
NODAL nodal growth differentiation factor
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX4 NADPH oxidase 4
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPPC natriuretic peptide C
NPY2R neuropeptide Y receptor Y2
NR3C2 nuclear receptor subfamily 3, group C, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
ORAI1 ORAI calcium release-activated calcium modulator 1
PALLD palladin, cytoskeletal associated protein
PARP1 poly (ADP-ribose) polymerase 1
PDGFB platelet-derived growth factor beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PEBP1 phosphatidylethanolamine binding protein 1
PEPD peptidase D
PFN1 profilin 1
PITX2 paired-like homeodomain 2
PLAGL1 pleiomorphic adenoma gene-like 1
POLG polymerase (DNA directed), gamma
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARA peroxisome proliferator-activated receptor alpha
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKCA protein kinase C, alpha
PRKD1 protein kinase D1
PRL prolactin
PRMT5 protein arginine methyltransferase 5
PTEN phosphatase and tensin homolog
PTH parathyroid hormone
PTH1R parathyroid hormone 1 receptor
PTK2 protein tyrosine kinase 2
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAP1A RAP1A, member of RAS oncogene family
RARB retinoic acid receptor, beta
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RCAN1 regulator of calcineurin 1
REN renin
RETN resistin
RGS3 regulator of G-protein signaling 3
RGS5 regulator of G-protein signaling 5
RHOA ras homolog family member A
RLN1 relaxin 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRAD Ras-related associated with diabetes
RUNX2 runt-related transcription factor 2
RYR1 ryanodine receptor 1 (skeletal)
S100A11 S100 calcium binding protein A11
S100B S100 calcium binding protein B
SCN5A sodium channel, voltage gated, type V alpha subunit
SDC4 syndecan 4
SELE selectin E
SHH sonic hedgehog
SHOX short stature homeobox
SHOX2 short stature homeobox 2
SIRPA signal-regulatory protein alpha
SIRT1 sirtuin 1
SLC25A46 solute carrier family 25, member 46
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD3 SMAD family member 3
SMN1 survival of motor neuron 1, telomeric
SP1 Sp1 transcription factor
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
STAB2 stabilin 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
STK3 serine/threonine kinase 3
TFAM transcription factor A, mitochondrial
TFB1M transcription factor B1, mitochondrial
TFB2M transcription factor B2, mitochondrial
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
THBS1 thrombospondin 1
THRB thyroid hormone receptor, beta
TK2 thymidine kinase 2, mitochondrial
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNNI3 troponin I type 3 (cardiac)
TNNI3K TNNI3 interacting kinase
TNNT2 troponin T type 2 (cardiac)
TOLLIP toll interacting protein
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TRAP1 TNF receptor-associated protein 1
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TWF1 twinfilin actin binding protein 1
TXN thioredoxin
UTS2R urotensin 2 receptor
VCAM1 vascular cell adhesion molecule 1
VCL vinculin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
YAP1 Yes-associated protein 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta