hyperuricemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood. (Human Disease Ontology, DOID_1920)
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Genes

184 genes co-occuring with the disease hyperuricemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.38609
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.37628
UMOD uromodulin 2.35821
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 2.27637
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 1.92482
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 1.79886
XDH xanthine dehydrogenase 1.68045
G6PC glucose-6-phosphatase, catalytic subunit 1.66015
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.56
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.53789
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.51369
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 1.49789
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 1.3987
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 1.39433
INS insulin 1.36509
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 1.33981
PRPS1 phosphoribosyl pyrophosphate synthetase 1 1.31537
SLC16A9 solute carrier family 16, member 9 1.29615
APRT adenine phosphoribosyltransferase 1.29396
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 1.23429
LRRC16A leucine rich repeat containing 16A 1.18281
LUC7L2 LUC7-like 2 (S. cerevisiae) 1.15752
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 1.15752
CRP C-reactive protein, pentraxin-related 1.1312
PFKM phosphofructokinase, muscle 1.09419
ALB albumin 1.09377
FBXL20 F-box and leucine-rich repeat protein 20 1.04924
PRPS2 phosphoribosyl pyrophosphate synthetase 2 1.04798
GPATCH8 G patch domain containing 8 1.04041
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 1.02903
GGT1 gamma-glutamyltransferase 1 1.01807
ACE angiotensin I converting enzyme 0.981794
REN renin 0.962891
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 0.949519
APOC3 apolipoprotein C-III 0.947852
COX18 COX18 cytochrome c oxidase assembly factor 0.944521
HNF1B HNF1 homeobox B 0.93497
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.914315
PPAT phosphoribosyl pyrophosphate amidotransferase 0.897872
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 0.873281
APOB apolipoprotein B 0.836017
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 0.835198
MOCOS molybdenum cofactor sulfurase 0.831918
PDZK1 PDZ domain containing 1 0.80936
ZNF365 zinc finger protein 365 0.772479
ADRB3 adrenoceptor beta 3 0.733406
NPHP1 nephronophthisis 1 (juvenile) 0.708364
ANKRD17 ankyrin repeat domain 17 0.698313
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 0.689492
FABP2 fatty acid binding protein 2, intestinal 0.672722
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.665563
CEP104 centrosomal protein 104kDa 0.661197
KHK ketohexokinase (fructokinase) 0.659611
PNP purine nucleoside phosphorylase 0.647348
LIN9 lin-9 DREAM MuvB core complex component 0.619834
GJA4 gap junction protein, alpha 4, 37kDa 0.61162
PARD3B par-3 family cell polarity regulator beta 0.60069
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.591727
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 0.587054
ADSL adenylosuccinate lyase 0.582384
ADSS adenylosuccinate synthase 0.580828
SAE1 SUMO1 activating enzyme subunit 1 0.569552
CABIN1 calcineurin binding protein 1 0.564889
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.563335
LEP leptin 0.557509
SPTA1 spectrin, alpha, erythrocytic 1 0.556732
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 0.543542
GDA guanine deaminase 0.535022
OIT3 oncoprotein induced transcript 3 0.526132
ZPBP2 zona pellucida binding protein 2 0.522659
GCG glucagon 0.518034
APOA1 apolipoprotein A-I 0.513417
STARD8 StAR-related lipid transfer (START) domain containing 8 0.501909
NPHP4 nephronophthisis 4 0.496175
B2M beta-2-microglobulin 0.487407
ALPPL2 alkaline phosphatase, placental-like 2 0.483604
ALPP alkaline phosphatase, placental 0.483224
ALPL alkaline phosphatase, liver/bone/kidney 0.482844
OR5K2 olfactory receptor, family 5, subfamily K, member 2 0.471089
TCTA T-cell leukemia translocation altered 0.468819
GGT2 gamma-glutamyltransferase 2 0.468441
ANKH ANKH inorganic pyrophosphate transport regulator 0.466172
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.455224
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.449194
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.446182
NLRP3 NLR family, pyrin domain containing 3 0.445805
LPA lipoprotein, Lp(a) 0.442795
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 0.434524
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 0.432646
COG2 component of oligomeric golgi complex 2 0.42739
TMOD4 tropomodulin 4 (muscle) 0.425139
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.421765
PTH parathyroid hormone 0.416521
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 0.411657
TMEM18 transmembrane protein 18 0.410161
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 0.406051
APOE apolipoprotein E 0.402692
LGALS9 lectin, galactoside-binding, soluble, 9 0.401945
TNF tumor necrosis factor 0.397098
CRYM crystallin, mu 0.394863
CLDN16 claudin 16 0.388909
IL1B interleukin 1, beta 0.381481
CYBA cytochrome b-245, alpha polypeptide 0.377031
PSRC1 proline/serine-rich coiled-coil 1 0.369997
ADA adenosine deaminase 0.367779
CCL2 chemokine (C-C motif) ligand 2 0.365562
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.359657
SOCS3 suppressor of cytokine signaling 3 0.359289
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.35892
G6PD glucose-6-phosphate dehydrogenase 0.358183
CARD17 caspase recruitment domain family, member 17 0.355604
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.353395
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.352291
SARS seryl-tRNA synthetase 0.328834
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.317545
PRRC2A proline-rich coiled-coil 2A 0.315729
CST3 cystatin C 0.31029
EMP1 epithelial membrane protein 1 0.307757
NARS asparaginyl-tRNA synthetase 0.301615
FBXO2 F-box protein 2 0.296571
MLXIPL MLX interacting protein-like 0.291898
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.287952
TTK TTK protein kinase 0.281868
SMCP sperm mitochondria-associated cysteine-rich protein 0.277227
HRAS Harvey rat sarcoma viral oncogene homolog 0.27153
EDN1 endothelin 1 0.270819
FBXO17 F-box protein 17 0.269043
BAG6 BCL2-associated athanogene 6 0.267622
FBXO42 F-box protein 42 0.257711
APOA2 apolipoprotein A-II 0.251015
MSH5 mutS homolog 5 0.250311
TAS1R1 taste receptor, type 1, member 1 0.248554
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 0.241196
PPARG peroxisome proliferator-activated receptor gamma 0.23945
CELA2A chymotrypsin-like elastase family, member 2A 0.239101
HEXA hexosaminidase A (alpha polypeptide) 0.23666
SPAG7 sperm associated antigen 7 0.233878
PYGB phosphorylase, glycogen; brain 0.231795
UBTF upstream binding transcription factor, RNA polymerase I 0.230063
PYGL phosphorylase, glycogen, liver 0.228679
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 0.228333
ADORA2A adenosine A2a receptor 0.227988
IL6 interleukin 6 0.226952
LCAT lecithin-cholesterol acyltransferase 0.226952
LYZ lysozyme 0.22454
NPHP3 nephronophthisis 3 (adolescent) 0.215992
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.215653
COPS2 COP9 signalosome subunit 2 0.213959
KIF3A kinesin family member 3A 0.212271
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.205916
PYGM phosphorylase, glycogen, muscle 0.205254
SOD2 superoxide dismutase 2, mitochondrial 0.203604
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.201962
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 0.201308
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5 0.199356
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 0.197742
KLHL17 kelch-like family member 17 0.19742
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.196139
LGALS13 lectin, galactoside-binding, soluble, 13 0.195183
PARVA parvin, alpha 0.1936
TRDN triadin 0.189859
CARD8 caspase recruitment domain family, member 8 0.189551
ADORA2B adenosine A2b receptor 0.188938
CAT catalase 0.188632
NAAA N-acylethanolamine acid amidase 0.188326
LPL lipoprotein lipase 0.185612
FTO fat mass and obesity associated 0.185313
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 0.180084
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 0.178682
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 0.178403
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.175947
PPARA peroxisome proliferator-activated receptor alpha 0.174881
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.174617
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.173832
ENO3 enolase 3 (beta, muscle) 0.170544
MCAM melanoma cell adhesion molecule 0.170299
LRP2 low density lipoprotein receptor-related protein 2 0.168854
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 0.168854
HCAR2 hydroxycarboxylic acid receptor 2 0.163523
CD79A CD79a molecule, immunoglobulin-associated alpha 0.162908
AARS alanyl-tRNA synthetase 0.159838
CFAP74 cilia and flagella associated protein 74 0.159658
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.158266
SUOX sulfite oxidase 0.157602