hypoglycemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

262 genes co-occuring with the disease hypoglycemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
INS insulin 4.36803
GCG glucagon 3.12475
DPP4 dipeptidyl-peptidase 4 2.41034
POMC proopiomelanocortin 2.26586
PPY pancreatic polypeptide 1.99641
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 1.98203
SST somatostatin 1.96004
IGF1 insulin-like growth factor 1 (somatomedin C) 1.83364
GHRH growth hormone releasing hormone 1.81871
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 1.80698
G6PC glucose-6-phosphatase, catalytic subunit 1.7546
GLP1R glucagon-like peptide 1 receptor 1.65879
IGF2 insulin-like growth factor 2 1.6561
TRH thyrotropin-releasing hormone 1.64576
CRH corticotropin releasing hormone 1.63635
GCK glucokinase (hexokinase 4) 1.59519
INSR insulin receptor 1.54937
GLUD1 glutamate dehydrogenase 1 1.52952
PRL prolactin 1.48428
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 1.47594
GAST gastrin 1.46671
GIP gastric inhibitory polypeptide 1.42411
IGFBP3 insulin-like growth factor binding protein 3 1.41183
ACADVL acyl-CoA dehydrogenase, very long chain 1.38166
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 1.34635
GH1 growth hormone 1 1.34548
HADH hydroxyacyl-CoA dehydrogenase 1.32323
IAPP islet amyloid polypeptide 1.31275
GLS2 glutaminase 2 (liver, mitochondrial) 1.30751
PC pyruvate carboxylase 1.28392
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.24993
AVP arginine vasopressin 1.24776
PYGL phosphorylase, glycogen, liver 1.24602
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 1.24385
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.20742
PYGB phosphorylase, glycogen; brain 1.20656
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 1.2018
HBA1 hemoglobin, alpha 1 1.20007
HBA2 hemoglobin, alpha 2 1.19143
PYGM phosphorylase, glycogen, muscle 1.1841
HK1 hexokinase 1 1.17121
GCGR glucagon receptor 1.15027
NPY neuropeptide Y 1.11898
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.1173
CPT1A carnitine palmitoyltransferase 1A (liver) 1.08747
IGFBP1 insulin-like growth factor binding protein 1 1.0774
FBP1 fructose-1,6-bisphosphatase 1 1.06564
ALB albumin 1.06186
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 1.0585
FFAR1 free fatty acid receptor 1 1.05261
CPT2 carnitine palmitoyltransferase 2 1.00246
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.998236
GYS2 glycogen synthase 2 (liver) 0.950352
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.936214
GHRL ghrelin/obestatin prepropeptide 0.933727
FOS FBJ murine osteosarcoma viral oncogene homolog 0.925039
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.916375
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.914727
LEP leptin 0.914315
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 0.894179
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.876966
REN renin 0.860999
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.839705
GCKR glucokinase (hexokinase 4) regulator 0.835198
ETFDH electron-transferring-flavoprotein dehydrogenase 0.822488
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 0.804436
MEN1 multiple endocrine neoplasia I 0.802385
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 0.792951
HCRT hypocretin (orexin) neuropeptide precursor 0.784345
ACE angiotensin I converting enzyme 0.772479
HNF4A hepatocyte nuclear factor 4, alpha 0.770844
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.768393
DLL1 delta-like 1 (Drosophila) 0.762678
GAL galanin/GMAP prepropeptide 0.755342
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.72612
GHR growth hormone receptor 0.724502
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 0.722482
MPI mannose phosphate isomerase 0.721673
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.718443
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 0.715215
F2 coagulation factor II (thrombin) 0.707559
NPS neuropeptide S 0.703134
GK glycerol kinase 0.699517
PFKM phosphofructokinase, muscle 0.694301
MLYCD malonyl-CoA decarboxylase 0.680697
OXCT1 3-oxoacid CoA transferase 1 0.668345
COASY CoA synthase 0.66755
GPR119 G protein-coupled receptor 119 0.6608
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.656441
HNF1A HNF1 homeobox A 0.648533
CSH2 chorionic somatomammotropin hormone 2 0.648138
TNF tumor necrosis factor 0.646165
DPP9 dipeptidyl-peptidase 9 0.64577
PNMT phenylethanolamine N-methyltransferase 0.639463
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.637889
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.634742
CHGA chromogranin A 0.633956
GPR142 G protein-coupled receptor 142 0.632777
PHKG2 phosphorylase kinase, gamma 2 (testis) 0.624927
PHKB phosphorylase kinase, beta 0.620617
DPP8 dipeptidyl-peptidase 8 0.610057
PER2 period circadian clock 2 0.596012
PRG4 proteoglycan 4 0.594454
PER1 period circadian clock 1 0.594064
TH tyrosine hydroxylase 0.585108
IL6 interleukin 6 0.578106
ALDOB aldolase B, fructose-bisphosphate 0.574605
LHX4 LIM homeobox 4 0.561392
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.558674
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.555568
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.538506
DGUOK deoxyguanosine kinase 0.530381
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.528063
PCSK2 proprotein convertase subtilisin/kexin type 2 0.524588
CCK cholecystokinin 0.521117
TEAD2 TEA domain family member 2 0.518034
PPARA peroxisome proliferator-activated receptor alpha 0.513417
PROP1 PROP paired-like homeobox 1 0.501144
SPATA21 spermatogenesis associated 21 0.496557
CORT cortistatin 0.492359
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.491597
GCDH glutaryl-CoA dehydrogenase 0.479807
ETFB electron-transfer-flavoprotein, beta polypeptide 0.479427
ACAT1 acetyl-CoA acetyltransferase 1 0.468819
PHKA2 phosphorylase kinase, alpha 2 (liver) 0.463527
PITPNA phosphatidylinositol transfer protein, alpha 0.462394
CALCA calcitonin-related polypeptide alpha 0.455224
ALPPL2 alkaline phosphatase, placental-like 2 0.448064
ALPP alkaline phosphatase, placental 0.447687
ALPL alkaline phosphatase, liver/bone/kidney 0.447311
FOXA3 forkhead box A3 0.436026
ACAD9 acyl-CoA dehydrogenase family, member 9 0.431519
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.42364
ACAT2 acetyl-CoA acetyltransferase 2 0.418768
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.41727
PPARG peroxisome proliferator-activated receptor gamma 0.41727
FOXM1 forkhead box M1 0.411657
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 0.403064
MPV17 MpV17 mitochondrial inner membrane protein 0.401945
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.397098
HESX1 HESX homeobox 1 0.395608
IL1B interleukin 1, beta 0.390397
LHX3 LIM homeobox 3 0.390025
GRP gastrin-releasing peptide 0.386679
GGT1 gamma-glutamyltransferase 1 0.382594
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.37629
POU1F1 POU class 1 homeobox 1 0.374068
LRRC4C leucine rich repeat containing 4C 0.368518
GHRHR growth hormone releasing hormone receptor 0.36704
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.35892
RRAGA Ras-related GTP binding A 0.358551
STX8 syntaxin 8 0.358183
CPT1C carnitine palmitoyltransferase 1C 0.354868
PPP1R3F protein phosphatase 1, regulatory subunit 3F 0.354499
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.349349
GFM1 G elongation factor, mitochondrial 1 0.348614
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.337608
PTH parathyroid hormone 0.335778
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.335778
GHSR growth hormone secretagogue receptor 0.335046
IRS1 insulin receptor substrate 1 0.331025
MLN motilin 0.327375
HAND2 heart and neural crest derivatives expressed 2 0.327375
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.324823
TF transferrin 0.321181
CRHR1 corticotropin releasing hormone receptor 1 0.312464
GPR83 G protein-coupled receptor 83 0.310652
ALDOC aldolase C, fructose-bisphosphate 0.310652
PER3 period circadian clock 3 0.31029
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.305948
IGF1R insulin-like growth factor 1 receptor 0.305587
EPHA5 EPH receptor A5 0.295132
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.294413
PDX1 pancreatic and duodenal homeobox 1 0.285444
TMEM56 transmembrane protein 56 0.280796
SLC30A3 solute carrier family 30 (zinc transporter), member 3 0.280082
CRP C-reactive protein, pentraxin-related 0.277584
NEIL3 nei endonuclease VIII-like 3 (E. coli) 0.277227
FOXO1 forkhead box O1 0.277227
CGA glycoprotein hormones, alpha polypeptide 0.272953
ADRB2 adrenoceptor beta 2, surface 0.270108
TXNIP thioredoxin interacting protein 0.267267
POLG polymerase (DNA directed), gamma 0.266558
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.259124
SREBF1 sterol regulatory element binding transcription factor 1 0.257358
CRHR2 corticotropin releasing hormone receptor 2 0.255946
MBOAT4 membrane bound O-acyltransferase domain containing 4 0.255241
MLX MLX, MAX dimerization protein 0.253479
PYY peptide YY 0.253127
FOXA2 forkhead box A2 0.251718
LPL lipoprotein lipase 0.250311
ACAA2 acetyl-CoA acyltransferase 2 0.250311
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.24996
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.246799
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.246799
NRK Nik related kinase 0.246448
DNAH8 dynein, axonemal, heavy chain 8 0.243295
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.241895
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.239799
GPX5 glutathione peroxidase 5 0.239799
SOD2 superoxide dismutase 2, mitochondrial 0.237706
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.237706
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.237706
GPX4 glutathione peroxidase 4 0.23666
IGFBP6 insulin-like growth factor binding protein 6 0.234225
AFP alpha-fetoprotein 0.231448
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 0.228679
AVPR1B arginine vasopressin receptor 1B 0.227297
PGM1 phosphoglucomutase 1 0.225917
VIP vasoactive intestinal peptide 0.22454
HINT2 histidine triad nucleotide binding protein 2 0.223165
GPX1 glutathione peroxidase 1 0.222822
AGRP agouti related neuropeptide 0.218715
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.217012
PKLR pyruvate kinase, liver and RBC 0.216332
CHKB choline kinase beta 0.214297
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.210253
NTS neurotensin 0.210253
ADORA1 adenosine A1 receptor 0.210253
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.208914
IL1A interleukin 1, alpha 0.208914
SIK3 SIK family kinase 3 0.207245
ALLC allantoicase 0.205585
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.204593
NGF nerve growth factor (beta polypeptide) 0.201962
SLC37A3 solute carrier family 37, member 3 0.198064
MEGF6 multiple EGF-like-domains 6 0.196779
GRIP1 glutamate receptor interacting protein 1 0.196459
SCG5 secretogranin V 0.195183
AMY2A amylase, alpha 2A (pancreatic) 0.1936
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.191097
CRAT carnitine O-acetyltransferase 0.190168
ILVBL ilvB (bacterial acetolactate synthase)-like 0.190168
SIRT6 sirtuin 6 0.189551
FBP2 fructose-1,6-bisphosphatase 2 0.187719
GHDC GH3 domain containing 0.186811
ZDHHC23 zinc finger, DHHC-type containing 23 0.181222
CA1 carbonic anhydrase I 0.180652
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 0.178403
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.175411
PAQR7 progestin and adipoQ receptor family member VII 0.174617
GCSAM germinal center-associated, signaling and motility 0.174093
FOCAD focadhesin 0.174093
GIPR gastric inhibitory polypeptide receptor 0.173314
ALDOA aldolase A, fructose-bisphosphate 0.172291
TTC19 tetratricopeptide repeat domain 19 0.172038
F3 coagulation factor III (thromboplastin, tissue factor) 0.171785
SMR3A submaxillary gland androgen regulated protein 3A 0.170544
PDK2 pyruvate dehydrogenase kinase, isozyme 2 0.168381
COG2 component of oligomeric golgi complex 2 0.167682
GBP3 guanylate binding protein 3 0.167682
MMD monocyte to macrophage differentiation-associated 0.167682
MC4R melanocortin 4 receptor 0.167224
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 0.166768
UQCRB ubiquinol-cytochrome c reductase binding protein 0.166095
PKM pyruvate kinase, muscle 0.165001
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.164149
OPRM1 opioid receptor, mu 1 0.163317
TPTE transmembrane phosphatase with tensin homology 0.159838
WWOX WW domain containing oxidoreductase 0.158778
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.158605
STAR steroidogenic acute regulatory protein 0.157765