hypogonadism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A gonadal disease that is characterized by diminished functional activity of the gonads. (Human Disease Ontology, DOID_1924)
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Genes

264 genes co-occuring with the disease hypogonadism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.66163
ANOS1 anosmin 1 2.57276
PROKR2 prokineticin receptor 2 2.24098
SHBG sex hormone-binding globulin 2.23033
PROK2 prokineticin 2 2.00608
GNRHR gonadotropin-releasing hormone receptor 1.92529
KISS1R KISS1 receptor 1.90102
FGFR1 fibroblast growth factor receptor 1 1.88759
PRL prolactin 1.74051
IGF1 insulin-like growth factor 1 (somatomedin C) 1.73049
CHD7 chromodomain helicase DNA binding protein 7 1.71362
FGF8 fibroblast growth factor 8 (androgen-induced) 1.66285
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 1.64621
NR0B1 nuclear receptor subfamily 0, group B, member 1 1.54584
TAC3 tachykinin 3 1.49394
TRH thyrotropin-releasing hormone 1.49087
LEP leptin 1.48911
AR androgen receptor 1.46715
PDE5A phosphodiesterase 5A, cGMP-specific 1.43771
POMC proopiomelanocortin 1.40876
PROP1 PROP paired-like homeobox 1 1.39783
TACR3 tachykinin receptor 3 1.38909
STS steroid sulfatase (microsomal), isozyme S 1.33632
FSHR follicle stimulating hormone receptor 1.32236
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 1.31886
BGLAP bone gamma-carboxyglutamate (gla) protein 1.28261
KLK3 kallikrein-related peptidase 3 1.2508
INS insulin 1.24168
DCAF17 DDB1 and CUL4 associated factor 17 1.20137
INSL3 insulin-like 3 (Leydig cell) 1.17378
KISS1 KiSS-1 metastasis-suppressor 1.14645
AMH anti-Mullerian hormone 1.13585
GHRH growth hormone releasing hormone 1.13501
SRY sex determining region Y 1.13036
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 1.12741
KRTAP9-3 keratin associated protein 9-3 1.10426
BBS1 Bardet-Biedl syndrome 1 1.07278
OTUD4 OTU deubiquitinase 4 1.06564
RNF216 ring finger protein 216 1.04882
OTUD4P1 OTUD4 pseudogene 1 1.04462
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 1.03072
PTH parathyroid hormone 1.02692
HESX1 HESX homeobox 1 1.00879
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 1.00583
HFE hemochromatosis 1.00077
LHCGR luteinizing hormone/choriogonadotropin receptor 0.979689
FLRT3 fibronectin leucine rich transmembrane protein 3 0.954943
TTC8 tetratricopeptide repeat domain 8 0.951604
PCSK1 proprotein convertase subtilisin/kexin type 1 0.947435
BBS4 Bardet-Biedl syndrome 4 0.941611
BBS12 Bardet-Biedl syndrome 12 0.934556
BBS10 Bardet-Biedl syndrome 10 0.930414
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.919261
SHOX short stature homeobox 0.913903
FTL ferritin, light polypeptide 0.909376
FTH1 ferritin, heavy polypeptide 1 0.909376
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.900746
VCX2 variable charge, X-linked 2 0.882701
LHB luteinizing hormone beta polypeptide 0.871643
SLC10A7 solute carrier family 10, member 7 0.856087
FSHB follicle stimulating hormone, beta polypeptide 0.85404
GALT galactose-1-phosphate uridylyltransferase 0.847078
HFE2 hemochromatosis type 2 (juvenile) 0.837656
VCX3A variable charge, X-linked 3A 0.821667
CALCA calcitonin-related polypeptide alpha 0.818385
IHH indian hedgehog 0.815924
BBS7 Bardet-Biedl syndrome 7 0.798282
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.791721
CRH corticotropin releasing hormone 0.778204
BBS5 Bardet-Biedl syndrome 5 0.77575
NHLH2 nescient helix loop helix 2 0.774114
ALMS1 Alstrom syndrome protein 1 0.759824
GHRL ghrelin/obestatin prepropeptide 0.741111
NDN necdin, melanoma antigen (MAGE) family member 0.740705
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.710378
TF transferrin 0.708767
SPAG5 sperm associated antigen 5 0.699517
PSMC3IP PSMC3 interacting protein 0.697109
LEPR leptin receptor 0.693098
BBS2 Bardet-Biedl syndrome 2 0.690694
IGFBP3 insulin-like growth factor binding protein 3 0.685891
IL17RD interleukin 17 receptor D 0.682693
SNRPN small nuclear ribonucleoprotein polypeptide N 0.681894
VCX variable charge, X-linked 0.680697
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.678302
FGF17 fibroblast growth factor 17 0.674315
NLGN4X neuroligin 4, X-linked 0.67312
STAR steroidogenic acute regulatory protein 0.658026
GOLGA8F golgin A8 family, member F 0.654463
GOLGA8EP golgin A8 family, member E, pseudogene 0.654463
GOLGA8G golgin A8 family, member G 0.654463
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.651694
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 0.648138
EBF2 early B-cell factor 2 0.641827
SPRY4 sprouty homolog 4 (Drosophila) 0.635528
PTER phosphotriesterase related 0.62728
VCX3B variable charge, X-linked 3B 0.618268
HELQ helicase, POLQ-like 0.618268
WHAMMP3 WAS protein homolog associated with actin, golgi membranes and microtubules pseudogene 3 0.617877
ARSE arylsulfatase E (chondrodysplasia punctata 1) 0.613574
ESR1 estrogen receptor 1 0.604201
LHX3 LIM homeobox 3 0.590558
MIB2 mindbomb E3 ubiquitin protein ligase 2 0.58939
RBM28 RNA binding motif protein 28 0.579661
AIRE autoimmune regulator 0.576939
TFR2 transferrin receptor 2 0.572273
ALB albumin 0.562169
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 0.556344
ALPL alkaline phosphatase, liver/bone/kidney 0.548583
SETDB1 SET domain, bifurcated 1 0.543542
C10ORF2 chromosome 10 open reading frame 2 0.534248
ALPPL2 alkaline phosphatase, placental-like 2 0.531928
ALPP alkaline phosphatase, placental 0.531541
PHF6 PHD finger protein 6 0.528449
FTHL17 ferritin, heavy polypeptide-like 17 0.528449
SYNE2 spectrin repeat containing, nuclear envelope 2 0.522273
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.520731
NPY neuropeptide Y 0.51611
CUL4B cullin 4B 0.50689
SST somatostatin 0.500379
TSHZ1 teashirt zinc finger homeobox 1 0.498849
NKX2-6 NK2 homeobox 6 0.495029
NPFFR1 neuropeptide FF receptor 1 0.485505
NPAP1 nuclear pore associated protein 1 0.484744
PPAP2A phosphatidic acid phosphatase type 2A 0.480945
FEZF1 FEZ family zinc finger 1 0.479807
YIPF7 Yip1 domain family, member 7 0.474119
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 0.471089
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.468819
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 0.465038
CRP C-reactive protein, pentraxin-related 0.463149
GK glycerol kinase 0.454093
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.448064
HAMP hepcidin antimicrobial peptide 0.445429
KL klotho 0.442418
SIM1 single-minded family bHLH transcription factor 1 0.436778
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.433397
NDP Norrie disease (pseudoglioma) 0.426265
UMODL1 uromodulin-like 1 0.419892
GH1 growth hormone 1 0.416521
ARID4B AT rich interactive domain 4B (RBP1-like) 0.415773
RXFP2 relaxin/insulin-like family peptide receptor 2 0.415773
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.413901
PYY peptide YY 0.397843
ZFY zinc finger protein, Y-linked 0.392629
DUSP6 dual specificity phosphatase 6 0.391885
XG Xg blood group 0.389653
USP26 ubiquitin specific peptidase 26 0.388538
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.385565
JMY junction mediating and regulatory protein, p53 cofactor 0.383337
GDF6 growth differentiation factor 6 0.374438
EXOC7 exocyst complex component 7 0.374438
FN1 fibronectin 1 0.372587
GALK1 galactokinase 1 0.367779
RAB33A RAB33A, member RAS oncogene family 0.36741
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 0.365562
DMRT2 doublesex and mab-3 related transcription factor 2 0.363716
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.35892
CMC4 C-x(9)-C motif containing 4 0.354499
ARL6 ADP-ribosylation factor-like 6 0.351187
BICC1 BicC family RNA binding protein 1 0.350084
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 0.349717
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.344941
CEP290 centrosomal protein 290kDa 0.344574
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.343106
DAZL deleted in azoospermia-like 0.342739
SNRPE small nuclear ribonucleoprotein polypeptide E 0.340906
ALX4 ALX homeobox 4 0.338341
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 0.33651
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 0.32993
FGF23 fibroblast growth factor 23 0.327375
TBX19 T-box 19 0.324823
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 0.324458
PRDM9 PR domain containing 9 0.323365
PIWIL4 piwi-like RNA-mediated gene silencing 4 0.32009
KIFC3 kinesin family member C3 0.316456
ZNF274 zinc finger protein 274 0.313189
RIN2 Ras and Rab interactor 2 0.31029
CARTPT CART prepropeptide 0.302337
IGFBP4 insulin-like growth factor binding protein 4 0.300894
IGSF1 immunoglobulin superfamily, member 1 0.299812
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.298731
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.298011
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.295851
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.294772
MKRN3 makorin ring finger protein 3 0.294053
ETF1 eukaryotic translation termination factor 1 0.294053
PMM1 phosphomannomutase 1 0.28831
PLK4 polo-like kinase 4 0.287235
TSGA10 testis specific, 10 0.286519
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.28616
ALX3 ALX homeobox 3 0.283297
RPS4Y1 ribosomal protein S4, Y-linked 1 0.28294
POLG polymerase (DNA directed), gamma 0.279011
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 0.278654
AGO2 argonaute RISC catalytic component 2 0.276514
DLX5 distal-less homeobox 5 0.276158
NHEJ1 nonhomologous end-joining factor 1 0.275445
TSPY1 testis specific protein, Y-linked 1 0.275089
FANCM Fanconi anemia, complementation group M 0.273664
ALX1 ALX homeobox 1 0.273664
CD4 CD4 molecule 0.272597
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.269398
TMPO thymopoietin 0.267977
CALCR calcitonin receptor 0.267622
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 0.266913
NPS neuropeptide S 0.263722
ACSBG1 acyl-CoA synthetase bubblegum family member 1 0.261599
SOX3 SRY (sex determining region Y)-box 3 0.261245
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.260538
FMR1 fragile X mental retardation 1 0.255241
FGFR2 fibroblast growth factor receptor 2 0.250311
NCEH1 neutral cholesterol ester hydrolase 1 0.249257
PREPL prolyl endopeptidase-like 0.246448
OXT oxytocin/neurophysin I prepropeptide 0.246098
FOXL2 forkhead box L2 0.242945
PSG5 pregnancy specific beta-1-glycoprotein 5 0.238403
AVP arginine vasopressin 0.23492
TSPY3 testis specific protein, Y-linked 3 0.232836
TSPY10 testis specific protein, Y-linked 10 0.232836
EMX1 empty spiracles homeobox 1 0.231448
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.231102
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.218715
SOX10 SRY (sex determining region Y)-box 10 0.214636
RAB18 RAB18, member RAS oncogene family 0.214297
IGFBP1 insulin-like growth factor binding protein 1 0.210925
HSD17B1P1 hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 0.207912
ADGRV1 adhesion G protein-coupled receptor V1 0.201962
CPE carboxypeptidase E 0.201962
GCG glucagon 0.196459
SIL1 SIL1 nucleotide exchange factor 0.196139
MPLKIP M-phase specific PLK1 interacting protein 0.195183
FGF1 fibroblast growth factor 1 (acidic) 0.190476
SDCCAG8 serologically defined colon cancer antigen 8 0.186811
AZU1 azurocidin 1 0.18651
UTF1 undifferentiated embryonic cell transcription factor 1 0.185313
WT1 Wilms tumor 1 0.183248
GCM1 glial cells missing homolog 1 (Drosophila) 0.182375
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.17896
PMM2 phosphomannomutase 2 0.175679
CASR calcium-sensing receptor 0.172291
CBX3 chromobox homolog 3 0.168617
OTX2 orthodenticle homeobox 2 0.163523
SOX2 SRY (sex determining region Y)-box 2 0.163111
GBA2 glucosidase, beta (bile acid) 2 0.162707
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 0.162306
DMPK dystrophia myotonica-protein kinase 0.162109
MCM8 minichromosome maintenance complex component 8 0.161716
WFS1 Wolfram syndrome 1 (wolframin) 0.159302
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.143324
AMELY amelogenin, Y-linked 0.143263
GPR143 G protein-coupled receptor 143 0.143082
EMX2 empty spiracles homeobox 2 0.142948
AMELX amelogenin, X-linked 0.142901
PROK1 prokineticin 1 0.142565
BMP5 bone morphogenetic protein 5 0.142097
SPRY2 sprouty homolog 2 (Drosophila) 0.141467
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.141344
SPTA1 spectrin, alpha, erythrocytic 1 0.141194
CKAP5 cytoskeleton associated protein 5 0.141133
LIN28B lin-28 homolog B (C. elegans) 0.140976
CHD1L chromodomain helicase DNA binding protein 1-like 0.138737
ANK1 ankyrin 1, erythrocytic 0.138399
GZMM granzyme M (lymphocyte met-ase 1) 0.137096