hypopituitarism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.|A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions. (Experimental Factor Ontology, EFO_0001380)
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Genes

110 genes co-occuring with the disease hypopituitarism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
POMC proopiomelanocortin 2.43099
HESX1 HESX homeobox 1 2.27741
PROP1 PROP paired-like homeobox 1 2.25795
IGF1 insulin-like growth factor 1 (somatomedin C) 2.22926
LHX4 LIM homeobox 4 2.11388
GHRH growth hormone releasing hormone 2.02522
TRH thyrotropin-releasing hormone 2.00056
POU1F1 POU class 1 homeobox 1 1.99687
LHX3 LIM homeobox 3 1.94783
SOX3 SRY (sex determining region Y)-box 3 1.92014
PRL prolactin 1.81104
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.74051
AVP arginine vasopressin 1.72137
INS insulin 1.64083
CRH corticotropin releasing hormone 1.43991
IGFBP3 insulin-like growth factor binding protein 3 1.27693
SST somatostatin 1.18023
GCG glucagon 1.16435
GH1 growth hormone 1 1.08873
GLI2 GLI family zinc finger 2 1.06396
TBX19 T-box 19 1.0606
OTX2 orthodenticle homeobox 2 1.0324
SOX2 SRY (sex determining region Y)-box 2 0.978006
SCRT1 scratch family zinc finger 1 0.913492
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.677903
FRS3 fibroblast growth factor receptor substrate 3 0.670333
SHBG sex hormone-binding globulin 0.663181
IGFBP1 insulin-like growth factor binding protein 1 0.659215
ILVBL ilvB (bacterial acetolactate synthase)-like 0.640251
MNX1 motor neuron and pancreas homeobox 1 0.635135
UFC1 ubiquitin-fold modifier conjugating enzyme 1 0.625319
LEP leptin 0.591337
CRHBP corticotropin releasing hormone binding protein 0.588612
GHR growth hormone receptor 0.587444
PITX2 paired-like homeodomain 2 0.573439
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.555568
GFRA2 GDNF family receptor alpha 2 0.528835
GHRL ghrelin/obestatin prepropeptide 0.523045
TG thyroglobulin 0.512264
TLE2 transducin-like enhancer of split 2 0.508041
ATP11C ATPase, class VI, type 11C 0.505356
SIX3 SIX homeobox 3 0.489691
NPAT nuclear protein, ataxia-telangiectasia locus 0.483985
SIX6 SIX homeobox 6 0.460883
GHRHR growth hormone releasing hormone receptor 0.446558
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.415024
BGLAP bone gamma-carboxyglutamate (gla) protein 0.411657
PROKR2 prokineticin receptor 2 0.405305
PITX1 paired-like homeodomain 1 0.392257
FOXRED1 FAD-dependent oxidoreductase domain containing 1 0.384079
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.383708
H1FX H1 histone family, member X 0.382223
IGF2 insulin-like growth factor 2 0.379256
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.378143
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.377773
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.372587
SHH sonic hedgehog 0.367779
CSH2 chorionic somatomammotropin hormone 2 0.363716
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.355235
CFC1 cripto, FRL-1, cryptic family 1 0.334681
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.332852
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.322637
ADGRV1 adhesion G protein-coupled receptor V1 0.320454
REN renin 0.309566
PROK2 prokineticin 2 0.309204
CD68 CD68 molecule 0.28151
THAP3 THAP domain containing, apoptosis associated protein 3 0.279011
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 0.27153
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.268332
NODAL nodal growth differentiation factor 0.264077
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.263722
CHD7 chromodomain helicase DNA binding protein 7 0.261245
SYP synaptophysin 0.257005
ZIC3 Zic family member 3 0.249257
SIM1 single-minded family bHLH transcription factor 1 0.242945
TRHR thyrotropin-releasing hormone receptor 0.23666
TSHB thyroid stimulating hormone, beta 0.23666
HADH hydroxyacyl-CoA dehydrogenase 0.23353
ADM2 adrenomedullin 2 0.215314
FOXH1 forkhead box H1 0.213621
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.212271
APOB apolipoprotein B 0.206248
AR androgen receptor 0.201635
RPL22 ribosomal protein L22 0.192031
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 0.191097
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.17896
PIDD1 p53-induced death domain protein 1 0.170299
GLI3 GLI family zinc finger 3 0.169091
AFP alpha-fetoprotein 0.159302
PNMA2 paraneoplastic Ma antigen 2 0.143255
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.142713
SATB2 SATB homeobox 2 0.142528
ZIC2 Zic family member 2 0.142528
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.142302
TNNT1 troponin T type 1 (skeletal, slow) 0.142127
SCG5 secretogranin V 0.141749
TCHH trichohyalin 0.141502
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.14146
CFD complement factor D (adipsin) 0.141277
IRF6 interferon regulatory factor 6 0.140855
IGFBP6 insulin-like growth factor binding protein 6 0.140003
AVPR2 arginine vasopressin receptor 2 0.138846
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.1387
WIPF2 WAS/WASL interacting protein family, member 2 0.138564
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.138348
PRTN3 proteinase 3 0.137751
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.137235
GCK glucokinase (hexokinase 4) 0.136412
LGALS3 lectin, galactoside-binding, soluble, 3 0.136081
IGFBP5 insulin-like growth factor binding protein 5 0.135471