hypothalamus Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description The ventral part of the diencephalon that forms the floor and part of the lateral wall of the third ventricle. Anatomically, it includes the preoptic area, optic tract, optic chiasm, mammillary bodies, tuber cinereum, infundibulum, and neurohypophysis, but for physiological purposes the neurohypophysis is considered a distinct structure. The hypothalamus may be divided into five regions or areas (area hypothalamica rostralis, area hypothalamica dorsalis, area hypothalamica intermedia, area hypothalamica lateralis and area hypothalamica posterior) or into three longitudinal zones (periventricular zone, medial zone, and lateral zone). The hypothalamic nuclei constitute that part of the corticodiencephalic mechanism that activates, controls and integrates the peripheral autonomic mechanisms, endocrine activity, and many somatic functions, e.g., a general regulation of water balance, body temperature, sleep, and food intake, and the development of secondary sex characteristics. The hypothalamus secretes vasopressin and oxytocin, which are stored in the pituitary, as well as many releasing factors (hypophysiotropic hormones), by means of which it exerts control over functions of the adenohypophysis. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000614)
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Genes

63 genes co-occuring with the biological term hypothalamus in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACVR2A activin A receptor, type IIA
ACVR2B activin A receptor, type IIB
AGTR1 angiotensin II receptor, type 1
AR androgen receptor
ASIP agouti signaling protein
BDNF brain-derived neurotrophic factor
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CRH corticotropin releasing hormone
CTSC cathepsin C
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPP4 dipeptidyl-peptidase 4
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FSHB follicle stimulating hormone, beta polypeptide
GCK glucokinase (hexokinase 4)
GH1 growth hormone 1
GHRH growth hormone releasing hormone
GPER1 G protein-coupled estrogen receptor 1
GPR50 G protein-coupled receptor 50
GRM1 glutamate receptor, metabotropic 1
GRP gastrin-releasing peptide
HCRT hypocretin (orexin) neuropeptide precursor
HMBOX1 homeobox containing 1
IL6R interleukin 6 receptor
INHBA inhibin, beta A
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
LEP leptin
LEPR leptin receptor
LHB luteinizing hormone beta polypeptide
LHX2 LIM homeobox 2
LINC00163 long intergenic non-protein coding RNA 163
MC4R melanocortin 4 receptor
MRAP2 melanocortin 2 receptor accessory protein 2
NKX2-1 NK2 homeobox 1
NPFFR1 neuropeptide FF receptor 1
NPVF neuropeptide VF precursor
NPY neuropeptide Y
NRD1 nardilysin (N-arginine dibasic convertase)
OXT oxytocin/neurophysin I prepropeptide
OXTR oxytocin receptor
PDYN prodynorphin
PMCH pro-melanin-concentrating hormone
POMC proopiomelanocortin
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
QRFP pyroglutamylated RFamide peptide
SF1 splicing factor 1
SHH sonic hedgehog
SIRT1 sirtuin 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SOD1 superoxide dismutase 1, soluble
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAC3 tachykinin 3
TGFB2 transforming growth factor, beta 2
TMEM18 transmembrane protein 18
TRH thyrotropin-releasing hormone
TRPV1 transient receptor potential cation channel, subfamily V, member 1
WDR6 WD repeat domain 6