hypothyroidism Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A deficiency of thyroid hormone. (Experimental Factor Ontology, EFO_0004705)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:1459
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Genes

87 genes associated with the disease hypothyroidism in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
PDE8B phosphodiesterase 8B 2.39342
DIO1 deiodinase, iodothyronine, type I 2.30112
PDE10A phosphodiesterase 10A 2.1372
LHX3 LIM homeobox 3 1.77455
SH2B3 SH2B adaptor protein 3 1.67004
ATXN2 ataxin 2 1.65612
NFIA nuclear factor I/A 1.65612
FGF7 fibroblast growth factor 7 1.63837
PRDM11 PR domain containing 11 1.57873
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 1.54733
INSR insulin receptor 1.54533
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.53633
VAV3 vav 3 guanine nucleotide exchange factor 1.51636
NRG1 neuregulin 1 1.47287
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.46748
GLIS3 GLIS family zinc finger 3 1.37327
LPCAT2 lysophosphatidylcholine acyltransferase 2 1.34719
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 1.16261
HLA-B major histocompatibility complex, class I, B 1.1576
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.14463
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.12515
C6ORF15 chromosome 6 open reading frame 15 1.10764
RECQL5 RecQ protein-like 5 1.00985
ZNF804B zinc finger protein 804B 1.00407
ASIC2 acid sensing (proton gated) ion channel 2 1.00407
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.00407
C1QTNF6 C1q and tumor necrosis factor related protein 6 0.971169
MTF1 metal-regulatory transcription factor 1 0.971169
HCG22 HLA complex group 22 0.964504
LOC100506999 uncharacterized LOC100506999 0.937304
TSHZ2 teashirt zinc finger homeobox 2 0.937304
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 0.912987
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.905653
PFKP phosphofructokinase, platelet 0.898875
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.892579
CLECL1 C-type lectin-like 1 0.874542
RAB20 RAB20, member RAS oncogene family 0.874542
CALN1 calneuron 1 0.869084
PRKCE protein kinase C, epsilon 0.858922
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.844278
ZDHHC17 zinc finger, DHHC-type containing 17 0.839855
THSD4 thrombospondin, type I, domain containing 4 0.831584
PCDH15 protocadherin-related 15 0.831584
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.808055
SNAP47 synaptosomal-associated protein, 47kDa 0.804621
AGER advanced glycosylation end product-specific receptor 0.79774
BTNL2 butyrophilin-like 2 0.794247
CNTNAP2 contactin associated protein-like 2 0.781342
FOXE1 forkhead box E1 0.775452
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 0.769887
FKTN fukutin 0.766993
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.748112
RBP4 retinol binding protein 4, plasma 0.743283
VMP1 vacuole membrane protein 1 0.74095
TTLL6 tubulin tyrosine ligase-like family member 6 0.734059
TRIM15 tripartite motif containing 15 0.731685
CAPZB capping protein (actin filament) muscle Z-line, beta 0.731685
ANKRD26 ankyrin repeat domain 26 0.727087
DFNB31 deafness, autosomal recessive 31 0.721383
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.718432
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 0.718432
IL2RA interleukin 2 receptor, alpha 0.712368
CLDN2 claudin 2 0.712368
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.71042
KIRREL3 kin of IRRE like 3 (Drosophila) 0.71042
KLHL29 kelch-like family member 29 0.708508
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.708508
CHL1 cell adhesion molecule L1-like 0.708508
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.70663
URI1 URI1, prefoldin-like chaperone 0.704784
OPCML opioid binding protein/cell adhesion molecule-like 0.699446
DAAM1 dishevelled associated activator of morphogenesis 1 0.694381
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.691138
TNNT3 troponin T type 3 (skeletal, fast) 0.689554
CNTN4 contactin 4 0.687994
GPC5 glypican 5 0.686457
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.686457
ERICH1 glutamate-rich 1 0.680534
ERCC5 excision repair cross-complementation group 5 0.674941
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.674941
MACROD2 MACRO domain containing 2 0.670943
MAN1C1 mannosidase, alpha, class 1C, member 1 0.669849
HCG9 HLA complex group 9 (non-protein coding) 0.572462
FGFR1OP FGFR1 oncogene partner 0.542589
LEMD2 LEM domain containing 2 0.498059
CLEC16A C-type lectin domain family 16, member A 0.498059
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.497696