hypoxic Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

329 genes co-occuring with the biological term hypoxic in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ADIPOQ adiponectin, C1Q and collagen domain containing
ADORA2B adenosine A2b receptor
ADRA1D adrenoceptor alpha 1D
AFP alpha-fetoprotein
AGER advanced glycosylation end product-specific receptor
AGO2 argonaute RISC catalytic component 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALAS2 5'-aminolevulinate synthase 2
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANGPTL4 angiopoietin-like 4
ANKH ANKH inorganic pyrophosphate transport regulator
APLN apelin
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATR ATR serine/threonine kinase
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BDNF brain-derived neurotrophic factor
BIRC5 baculoviral IAP repeat containing 5
BMF Bcl2 modifying factor
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRCA1 breast cancer 1, early onset
BSG basigin (Ok blood group)
C19ORF33 chromosome 19 open reading frame 33
CA12 carbonic anhydrase XII
CA9 carbonic anhydrase IX
CAPNS1 calpain, small subunit 1
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHKA choline kinase alpha
CHMP4A charged multivesicular body protein 4A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A1 collagen, type I, alpha 1
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CTBP1 C-terminal binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSL cathepsin L
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYGB cytoglobin
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DLL4 delta-like 4 (Drosophila)
DPYSL3 dihydropyrimidinase-like 3
DUSP9 dual specificity phosphatase 9
DYNLT1 dynein, light chain, Tctex-type 1
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EDN1 endothelin 1
EEF2 eukaryotic translation elongation factor 2
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELAVL1 ELAV like RNA binding protein 1
ELF2 E74-like factor 2 (ets domain transcription factor)
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
EPO erythropoietin
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC6 excision repair cross-complementation group 6
ERN1 endoplasmic reticulum to nucleus signaling 1
ERO1L ERO1-like (S. cerevisiae)
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP1 fatty acid binding protein 1, liver
FABP3 fatty acid binding protein 3, muscle and heart
FABP4 fatty acid binding protein 4, adipocyte
FASN fatty acid synthase
FGF2 fibroblast growth factor 2 (basic)
FGF8 fibroblast growth factor 8 (androgen-induced)
FLT1 fms-related tyrosine kinase 1
FLT4 fms-related tyrosine kinase 4
FOXO3 forkhead box O3
FXN frataxin
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GDF15 growth differentiation factor 15
GFAP glial fibrillary acidic protein
GJA1 gap junction protein, alpha 1, 43kDa
GLIS1 GLIS family zinc finger 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GYS1 glycogen synthase 1 (muscle)
H19 H19, imprinted maternally expressed transcript (non-protein coding)
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HDC histidine decarboxylase
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIF3A hypoxia inducible factor 3, alpha subunit
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AA2P heat shock protein 90kDa alpha (cytosolic), class A member 2, pseudogene
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNG interferon, gamma
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL15 interleukin 15
IL1B interleukin 1, beta
IL6 interleukin 6
ILK integrin-linked kinase
INHBA inhibin, beta A
INSIG2 insulin induced gene 2
ITGAV integrin, alpha V
ITGB6 integrin, beta 6
JAG2 jagged 2
JAK2 Janus kinase 2
JMY junction mediating and regulatory protein, p53 cofactor
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM3A lysine (K)-specific demethylase 3A
KDM4B lysine (K)-specific demethylase 4B
KDR kinase insert domain receptor
KEAP1 kelch-like ECH-associated protein 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT18 keratin 18, type I
LAMP3 lysosomal-associated membrane protein 3
LEP leptin
LOX lysyl oxidase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA11 melanoma antigen family A11
MAP2 microtubule-associated protein 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MB myoglobin
MCL1 myeloid cell leukemia 1
MDK midkine (neurite growth-promoting factor 2)
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR107 microRNA 107
MIR143 microRNA 143
MIR145 microRNA 145
MIR17 microRNA 17
MIR210 microRNA 210
MIR449A microRNA 449a
MIR675 microRNA 675
MIR93 microRNA 93
MITF microphthalmia-associated transcription factor
MKI67 marker of proliferation Ki-67
MLYCD malonyl-CoA decarboxylase
MME membrane metallo-endopeptidase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MOCS2 molybdenum cofactor synthesis 2
MSTN myostatin
MT3 metallothionein 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MUC17 mucin 17, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NACA nascent polypeptide-associated complex alpha subunit
NDRG1 N-myc downstream regulated 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGB neuroglobin
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX4 NADPH oxidase 4
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTN1 netrin 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PADI2 peptidyl arginine deiminase, type II
PDCD5 programmed cell death 5
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PGK1 phosphoglycerate kinase 1
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAGL2 pleiomorphic adenoma gene-like 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POMC proopiomelanocortin
POR P450 (cytochrome) oxidoreductase
POSTN periostin, osteoblast specific factor
POU5F1 POU class 5 homeobox 1
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRNP prion protein
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROM1 prominin 1
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTX3 pentraxin 3, long
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1A RAP1A, member of RAS oncogene family
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SCARA3 scavenger receptor class A, member 3
SCO2 SCO2 cytochrome c oxidase assembly protein
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIRT1 sirtuin 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNAI2 snail family zinc finger 2
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SOX2 SRY (sex determining region Y)-box 2
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
SPRY4 sprouty homolog 4 (Drosophila)
SREBF1 sterol regulatory element binding transcription factor 1
SRPK1 SRSF protein kinase 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5B signal transducer and activator of transcription 5B
SULF1 sulfatase 1
TAGLN transgelin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEAD4 TEA domain family member 4
TERT telomerase reverse transcriptase
TF transferrin
TGFB1 transforming growth factor, beta 1
TH tyrosine hydroxylase
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
TLL1 tolloid-like 1
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
TREM1 triggering receptor expressed on myeloid cells 1
TRIP11 thyroid hormone receptor interactor 11
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TUBB3 tubulin, beta 3 class III
TWIST1 twist family bHLH transcription factor 1
TWIST2 twist family bHLH transcription factor 2
UBE2T ubiquitin-conjugating enzyme E2T
UCA1 urothelial cancer associated 1 (non-protein coding)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
UGP2 UDP-glucose pyrophosphorylase 2
UNC5B unc-5 homolog B (C. elegans)
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
USF1 upstream transcription factor 1
USF2 upstream transcription factor 2, c-fos interacting
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VLDLR very low density lipoprotein receptor
VWF von Willebrand factor
WNT1 wingless-type MMTV integration site family, member 1
WNT10B wingless-type MMTV integration site family, member 10B
ZNF217 zinc finger protein 217