ifosfamide-3485 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the ifosfamide-3485 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ANKRD12 ankyrin repeat domain 12
ANKRD6 ankyrin repeat domain 6
APLP2 amyloid beta (A4) precursor-like protein 2
ASF1A anti-silencing function 1A histone chaperone
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BMP8B bone morphogenetic protein 8b
BTBD7 BTB (POZ) domain containing 7
CD58 CD58 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CLCC1 chloride channel CLIC-like 1
COX5B cytochrome c oxidase subunit Vb
CRYBG3 beta-gamma crystallin domain containing 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EIF5B eukaryotic translation initiation factor 5B
EZR ezrin
FBXO11 F-box protein 11
FGFR1OP FGFR1 oncogene partner
FGFR2 fibroblast growth factor receptor 2
GPATCH4 G patch domain containing 4
GRSF1 G-rich RNA sequence binding factor 1
GUK1 guanylate kinase 1
H2AFX H2A histone family, member X
HDAC5 histone deacetylase 5
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTT huntingtin
IER3IP1 immediate early response 3 interacting protein 1
ING2 inhibitor of growth family, member 2
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KRAS Kirsten rat sarcoma viral oncogene homolog
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MED18 mediator complex subunit 18
MRPL41 mitochondrial ribosomal protein L41
NCKAP1 NCK-associated protein 1
NFIB nuclear factor I/B
NOP14-AS1 NOP14 antisense RNA 1
NOP16 NOP16 nucleolar protein
NPEPPS aminopeptidase puromycin sensitive
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OAZ3 ornithine decarboxylase antizyme 3
OPHN1 oligophrenin 1
OSGIN2 oxidative stress induced growth inhibitor family member 2
PAPOLA poly(A) polymerase alpha
PAWR PRKC, apoptosis, WT1, regulator
PGK1 phosphoglycerate kinase 1
PMCH pro-melanin-concentrating hormone
PRRC2C proline-rich coiled-coil 2C
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB2A RAB2A, member RAS oncogene family
RANBP1 RAN binding protein 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RHEB Ras homolog enriched in brain
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae)
RPAIN RPA interacting protein
RPL14 ribosomal protein L14
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
S100A8 S100 calcium binding protein A8
SAP30 Sin3A-associated protein, 30kDa
SCAND2P SCAN domain containing 2 pseudogene
SH3BP2 SH3-domain binding protein 2
SIAH1 siah E3 ubiquitin protein ligase 1
SIKE1 suppressor of IKBKE 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SPRR1B small proline-rich protein 1B
SRR serine racemase
STON1 stonin 1
TAPBP TAP binding protein (tapasin)
TFG TRK-fused gene
TM6SF1 transmembrane 6 superfamily member 1
TRAM1 translocation associated membrane protein 1
TWF1 twinfilin actin binding protein 1
TXN thioredoxin
UBE2I ubiquitin-conjugating enzyme E2I
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VDAC3 voltage-dependent anion channel 3
WAPAL wings apart-like homolog (Drosophila)
WSB1 WD repeat and SOCS box containing 1
YIPF4 Yip1 domain family, member 4
YY1 YY1 transcription factor
ZNF639 zinc finger protein 639
ZNF770 zinc finger protein 770

decreased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABI3BP ABI family, member 3 (NESH) binding protein
ALDOC aldolase C, fructose-bisphosphate
AP1B1 adaptor-related protein complex 1, beta 1 subunit
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
B9D2 B9 protein domain 2
BAG4 BCL2-associated athanogene 4
BANP BTG3 associated nuclear protein
BCORL1 BCL6 corepressor-like 1
C16ORF45 chromosome 16 open reading frame 45
C2ORF54 chromosome 2 open reading frame 54
CAMTA2 calmodulin binding transcription activator 2
CAPN15 calpain 15
CASZ1 castor zinc finger 1
CCDC121 coiled-coil domain containing 121
CCDC176 coiled-coil domain containing 176
CCDC25 coiled-coil domain containing 25
CCDC85C coiled-coil domain containing 85C
CCNO cyclin O
CDK3 cyclin-dependent kinase 3
CEP170B centrosomal protein 170B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIC capicua transcriptional repressor
CLDN9 claudin 9
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CORT cortistatin
CRLF1 cytokine receptor-like factor 1
CTAGE9 CTAGE family, member 9
CTNNBIP1 catenin, beta interacting protein 1
DSCAM Down syndrome cell adhesion molecule
DUSP8 dual specificity phosphatase 8
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EPPK1 epiplakin 1
FAM131A family with sequence similarity 131, member A
FAM198B family with sequence similarity 198, member B
FAM50B family with sequence similarity 50, member B
FZD4 frizzled class receptor 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPATCH3 G patch domain containing 3
GPR143 G protein-coupled receptor 143
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H3B histone cluster 1, H3b
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INO80D INO80 complex subunit D
IRF1 interferon regulatory factor 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KLC2 kinesin light chain 2
KRT13 keratin 13, type I
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LPAR4 lysophosphatidic acid receptor 4
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAPK10 mitogen-activated protein kinase 10
MFAP2 microfibrillar-associated protein 2
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MYL5 myosin, light chain 5, regulatory
NEK11 NIMA-related kinase 11
PCSK7 proprotein convertase subtilisin/kexin type 7
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLXNA3 plexin A3
POLH polymerase (DNA directed), eta
RAB3D RAB3D, member RAS oncogene family
RCAN3 RCAN family member 3
RFTN1 raftlin, lipid raft linker 1
RGS19 regulator of G-protein signaling 19
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC12A8 solute carrier family 12, member 8
SLC22A14 solute carrier family 22, member 14
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STARD5 StAR-related lipid transfer (START) domain containing 5
STBD1 starch binding domain 1
STK16 serine/threonine kinase 16
SULT4A1 sulfotransferase family 4A, member 1
TARP TCR gamma alternate reading frame protein
TCTA T-cell leukemia translocation altered
TESC tescalcin
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNS2 tensin 2
TPRA1 transmembrane protein, adipocyte asscociated 1
TUBA3C tubulin, alpha 3c
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
VAX2 ventral anterior homeobox 2
WDR33 WD repeat domain 33
ZFHX3 zinc finger homeobox 3
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF34 zinc finger protein 34