ifosfamide-5805 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ifosfamide-5805 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ACSS3 acyl-CoA synthetase short-chain family member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAP2 ArfGAP with dual PH domains 2
ADRBK2 adrenergic, beta, receptor kinase 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALPK1 alpha-kinase 1
ANP32A-IT1 ANP32A intronic transcript 1
ARMCX2 armadillo repeat containing, X-linked 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BTN3A1 butyrophilin, subfamily 3, member A1
C14ORF1 chromosome 14 open reading frame 1
C1ORF95 chromosome 1 open reading frame 95
C9ORF9 chromosome 9 open reading frame 9
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLDN17 claudin 17
CORO2B coronin, actin binding protein, 2B
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRISP2 cysteine-rich secretory protein 2
CST4 cystatin S
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DENND3 DENN/MADD domain containing 3
DFNB31 deafness, autosomal recessive 31
DZIP1 DAZ interacting zinc finger protein 1
EBF2 early B-cell factor 2
EMC1 ER membrane protein complex subunit 1
EPS8L3 EPS8-like 3
GATA3 GATA binding protein 3
GPATCH4 G patch domain containing 4
GRIP2 glutamate receptor interacting protein 2
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HOXB2 homeobox B2
IGFBP7 insulin-like growth factor binding protein 7
IL12RB2 interleukin 12 receptor, beta 2
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL2RB interleukin 2 receptor, beta
IRF5 interferon regulatory factor 5
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
JUND jun D proto-oncogene
KCNA10 potassium channel, voltage gated shaker related subfamily A, member 10
KDM4B lysine (K)-specific demethylase 4B
KIAA0125 KIAA0125
KLK2 kallikrein-related peptidase 2
KRT17 keratin 17, type I
KSR1 kinase suppressor of ras 1
LOX lysyl oxidase
MAP3K7CL MAP3K7 C-terminal like
MX2 MX dynamin-like GTPase 2
MYO9B myosin IXB
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit
NCOR2 nuclear receptor corepressor 2
NKAIN1 Na+/K+ transporting ATPase interacting 1
PAIP2B poly(A) binding protein interacting protein 2B
PAX2 paired box 2
PEX16 peroxisomal biogenesis factor 16
PIP prolactin-induced protein
PKNOX2 PBX/knotted 1 homeobox 2
PLIN2 perilipin 2
PLK4 polo-like kinase 4
PRB1 proline-rich protein BstNI subfamily 1
PROL1 proline rich, lacrimal 1
PSD4 pleckstrin and Sec7 domain containing 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
RBPMS RNA binding protein with multiple splicing
REEP1 receptor accessory protein 1
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RSU1 Ras suppressor protein 1
RTCA RNA 3'-terminal phosphate cyclase
RUNX1 runt-related transcription factor 1
SAYSD1 SAYSVFN motif domain containing 1
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SEZ6L seizure related 6 homolog (mouse)-like
SKIL SKI-like proto-oncogene
SLA Src-like-adaptor
SOX21 SRY (sex determining region Y)-box 21
SRRT serrate, RNA effector molecule
STAB1 stabilin 1
TACR1 tachykinin receptor 1
TAGLN3 transgelin 3
TBC1D2B TBC1 domain family, member 2B
TBX2 T-box 2
TFIP11 tuftelin interacting protein 11
TLR4 toll-like receptor 4
TM4SF4 transmembrane 4 L six family member 4
TMEM180 transmembrane protein 180
TP63 tumor protein p63
TUBA3C tubulin, alpha 3c
U2AF2 U2 small nuclear RNA auxiliary factor 2
WNT3 wingless-type MMTV integration site family, member 3
ZER1 zyg-11 related, cell cycle regulator
ZNF529 zinc finger protein 529

decreased expression

Symbol Name
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP10D ATPase, class V, type 10D
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BBC3 BCL2 binding component 3
BEX4 brain expressed, X-linked 4
C1QTNF3 C1q and tumor necrosis factor related protein 3
C1RL complement component 1, r subcomponent-like
CBX4 chromobox homolog 4
CCDC106 coiled-coil domain containing 106
CFAP45 cilia and flagella associated protein 45
CHEK2 checkpoint kinase 2
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CRY2 cryptochrome circadian clock 2
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EXOC6B exocyst complex component 6B
FAM86C1 family with sequence similarity 86, member C1
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL15 F-box and leucine-rich repeat protein 15
FGF23 fibroblast growth factor 23
FKBP10 FK506 binding protein 10, 65 kDa
FKBP5 FK506 binding protein 5
FMO4 flavin containing monooxygenase 4
FOXC1 forkhead box C1
HIST1H1D histone cluster 1, H1d
HIST1H2AI histone cluster 1, H2ai
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC10 homeobox C10
HSF2BP heat shock transcription factor 2 binding protein
IDI2-AS1 IDI2 antisense RNA 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KDM8 lysine (K)-specific demethylase 8
KIF13B kinesin family member 13B
KLHL28 kelch-like family member 28
LAX1 lymphocyte transmembrane adaptor 1
LIG4 ligase IV, DNA, ATP-dependent
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMO7 LIM domain 7
LOC100287590 uncharacterized LOC100287590
LRP3 low density lipoprotein receptor-related protein 3
LRRK1 leucine-rich repeat kinase 1
MANBA mannosidase, beta A, lysosomal
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MVD mevalonate (diphospho) decarboxylase
MX1 MX dynamin-like GTPase 1
MYLIP myosin regulatory light chain interacting protein
NOTCH1 notch 1
NPM3 nucleophosmin/nucleoplasmin 3
NT5C 5', 3'-nucleotidase, cytosolic
OR3A3 olfactory receptor, family 3, subfamily A, member 3
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAQR5 progestin and adipoQ receptor family member V
PCBP4 poly(rC) binding protein 4
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLAC8 placenta-specific 8
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRR4 proline rich 4 (lacrimal)
PRSS8 protease, serine, 8
PSG4 pregnancy specific beta-1-glycoprotein 4
PTPRH protein tyrosine phosphatase, receptor type, H
PXMP4 peroxisomal membrane protein 4, 24kDa
R3HCC1L R3H domain and coiled-coil containing 1-like
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL13P5 ribosomal protein L13 pseudogene 5
S100A3 S100 calcium binding protein A3
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCARA3 scavenger receptor class A, member 3
SELL selectin L
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SHPK sedoheptulokinase
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SOX12 SRY (sex determining region Y)-box 12
STARD3 StAR-related lipid transfer (START) domain containing 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D17 TBC1 domain family, member 17
TMEM121 transmembrane protein 121
TPST2 tyrosylprotein sulfotransferase 2
USP20 ubiquitin specific peptidase 20
VASH1 vasohibin 1
WFDC2 WAP four-disulfide core domain 2
YY2 YY2 transcription factor
ZBTB6 zinc finger and BTB domain containing 6
ZNF280A zinc finger protein 280A
ZNF350 zinc finger protein 350
ZNF423 zinc finger protein 423
ZNF428 zinc finger protein 428
ZNF76 zinc finger protein 76