igf1r Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description insulin-like growth factor 1 receptor|This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 3480)
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Genes

122 genes co-occuring with the biological term igf1r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
AGTR1 angiotensin II receptor, type 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
AR androgen receptor
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BCL2L1 BCL2-like 1
BGLAP bone gamma-carboxyglutamate (gla) protein
CAV1 caveolin 1, caveolae protein, 22kDa
CD44 CD44 molecule (Indian blood group)
CDH13 cadherin 13
CDK4 cyclin-dependent kinase 4
CLTA clathrin, light chain A
CXCR4 chemokine (C-X-C motif) receptor 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPHA3 EPH receptor A3
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZR ezrin
FGFR1 fibroblast growth factor receptor 1
FOXO3 forkhead box O3
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HOXA9 homeobox A9
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IFNB1 interferon, beta 1, fibroblast
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KANK1 KN motif and ankyrin repeat domains 1
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LEF1 lymphoid enhancer-binding factor 1
LIMA1 LIM domain and actin binding 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MIR133A1 microRNA 133a-1
MIR133B microRNA 133b
MIR140 microRNA 140
MIR150 microRNA 150
MIR16-1 microRNA 16-1
MIR181B1 microRNA 181b-1
MIR195 microRNA 195
MIR223 microRNA 223
MIR375 microRNA 375
MIR376A1 microRNA 376a-1
MIR376C microRNA 376c
MIR383 microRNA 383
MIR431 microRNA 431
MIR497 microRNA 497
MIR503 microRNA 503
MIR515-1 microRNA 515-1
MIR515-2 microRNA 515-2
MIR630 microRNA 630
MIR7-1 microRNA 7-1
MIR99A microRNA 99a
MIRLET7A1 microRNA let-7a-1
MIRLET7C microRNA let-7c
MIRLET7I microRNA let-7i
MMP11 matrix metallopeptidase 11
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MVP major vault protein
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX3-1 NK3 homeobox 1
NOTCH1 notch 1
NTS neurotensin
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PDZK1 PDZ domain containing 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRKCD protein kinase C, delta
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
SDC1 syndecan 1
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHOX short stature homeobox
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSX1 synovial sarcoma, X breakpoint 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUMO1 small ubiquitin-like modifier 1
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB1 transforming growth factor, beta 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP73 tumor protein p73
UBE2I ubiquitin-conjugating enzyme E2I
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase