igfbp3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description insulin-like growth factor binding protein 3|This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3486)
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Genes

90 genes co-occuring with the biological term igfbp3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
AURKA aurora kinase A
BAG1 BCL2-associated athanogene
BCL2 B-cell CLL/lymphoma 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDX2 caudal type homeobox 2
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
EGF epidermal growth factor
EGR1 early growth response 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOXA1 forkhead box A1
FTO fat mass and obesity associated
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GH1 growth hormone 1
GHR growth hormone receptor
GHRL ghrelin/obestatin prepropeptide
GSTP1 glutathione S-transferase pi 1
HCRT hypocretin (orexin) neuropeptide precursor
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOXA@ homeobox A cluster
HOXC6 homeobox C6
HOXD@ homeobox D cluster
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
INS insulin
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
JUNB jun B proto-oncogene
KL klotho
LEP leptin
LRP1 low density lipoprotein receptor-related protein 1
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MIR21 microRNA 21
MMP1 matrix metallopeptidase 1
MMP19 matrix metallopeptidase 19
MMP3 matrix metallopeptidase 3
NKX3-1 NK3 homeobox 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRN1 neuritin 1
PCA3 prostate cancer associated 3 (non-protein coding)
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAT plasminogen activator, tissue
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RXRA retinoid X receptor, alpha
S1PR1 sphingosine-1-phosphate receptor 1
S1PR3 sphingosine-1-phosphate receptor 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHBG sex hormone-binding globulin
SP1 Sp1 transcription factor
SPHK1 sphingosine kinase 1
SREBF2 sterol regulatory element binding transcription factor 2
SSTR5 somatostatin receptor 5
STAT1 signal transducer and activator of transcription 1, 91kDa
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
THRA thyroid hormone receptor, alpha
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMP2 TIMP metallopeptidase inhibitor 2
TNF tumor necrosis factor
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TTR transthyretin
TXNIP thioredoxin interacting protein
USF1 upstream transcription factor 1
USF2 upstream transcription factor 2, c-fos interacting
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A