iloprost-496 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the iloprost-496 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ACSL4 acyl-CoA synthetase long-chain family member 4
ADAM20 ADAM metallopeptidase domain 20
ADRA1A adrenoceptor alpha 1A
AFF1 AF4/FMR2 family, member 1
AHI1 Abelson helper integration site 1
ALK anaplastic lymphoma receptor tyrosine kinase
AMT aminomethyltransferase
ANAPC2 anaphase promoting complex subunit 2
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARR3 arrestin 3, retinal (X-arrestin)
ASCC1 activating signal cointegrator 1 complex subunit 1
ASRGL1 asparaginase like 1
ATP10A ATPase, class V, type 10A
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCR breakpoint cluster region
BEST2 bestrophin 2
BICD1 bicaudal D homolog 1 (Drosophila)
C11ORF49 chromosome 11 open reading frame 49
C11ORF68 chromosome 11 open reading frame 68
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C20ORF27 chromosome 20 open reading frame 27
CD22 CD22 molecule
CHRM4 cholinergic receptor, muscarinic 4
CISH cytokine inducible SH2-containing protein
CLEC4E C-type lectin domain family 4, member E
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CTRC chymotrypsin C (caldecrin)
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DNAH3 dynein, axonemal, heavy chain 3
DNAH6 dynein, axonemal, heavy chain 6
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
EGR4 early growth response 4
FBXO11 F-box protein 11
FBXO42 F-box protein 42
FLRT1 fibronectin leucine rich transmembrane protein 1
FOXA2 forkhead box A2
FXR2 fragile X mental retardation, autosomal homolog 2
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GLDC glycine dehydrogenase (decarboxylating)
GPSM2 G-protein signaling modulator 2
HDAC2 histone deacetylase 2
HFE hemochromatosis
HLA-E major histocompatibility complex, class I, E
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LINC00339 long intergenic non-protein coding RNA 339
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MOGAT2 monoacylglycerol O-acyltransferase 2
MST1R macrophage stimulating 1 receptor
MXD4 MAX dimerization protein 4
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYO15A myosin XVA
NPAT nuclear protein, ataxia-telangiectasia locus
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
NPTX1 neuronal pentraxin I
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
PDZK1IP1 PDZK1 interacting protein 1
PHACTR1 phosphatase and actin regulator 1
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PPAN peter pan homolog (Drosophila)
PQLC3 PQ loop repeat containing 3
PRB1 proline-rich protein BstNI subfamily 1
PRPF6 pre-mRNA processing factor 6
PRRC2A proline-rich coiled-coil 2A
RGS11 regulator of G-protein signaling 11
RHOT2 ras homolog family member T2
RPS2 ribosomal protein S2
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RRP1 ribosomal RNA processing 1
SEZ6L seizure related 6 homolog (mouse)-like
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMAGP small cell adhesion glycoprotein
SOCS1 suppressor of cytokine signaling 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT5A signal transducer and activator of transcription 5A
SUGP2 SURP and G patch domain containing 2
TPI1 triosephosphate isomerase 1
TRIM14 tripartite motif containing 14
TRIM23 tripartite motif containing 23
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TST thiosulfate sulfurtransferase (rhodanese)
TSTA3 tissue specific transplantation antigen P35B
USF2 upstream transcription factor 2, c-fos interacting
VEGFA vascular endothelial growth factor A
WDR48 WD repeat domain 48
ZCCHC4 zinc finger, CCHC domain containing 4
ZNF32 zinc finger protein 32
ZNF33B zinc finger protein 33B
ZNF460 zinc finger protein 460
ZNF586 zinc finger protein 586
ZNF589 zinc finger protein 589
ZNF609 zinc finger protein 609
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
AGMAT agmatine ureohydrolase (agmatinase)
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
AXIN1 axin 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEST1 bestrophin 1
C9ORF114 chromosome 9 open reading frame 114
CA6 carbonic anhydrase VI
CCP110 centriolar coiled coil protein 110kDa
CDCA8 cell division cycle associated 8
CLCN2 chloride channel, voltage-sensitive 2
CLDN17 claudin 17
CLTCL1 clathrin, heavy chain-like 1
CNPY3 canopy FGF signaling regulator 3
COCH cochlin
COG7 component of oligomeric golgi complex 7
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CPEB1 cytoplasmic polyadenylation element binding protein 1
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CRNN cornulin
CRYAA crystallin, alpha A
CRYAB crystallin, alpha B
CRYZL1 crystallin, zeta (quinone reductase)-like 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DGKD diacylglycerol kinase, delta 130kDa
DPP3 dipeptidyl-peptidase 3
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EMID1 EMI domain containing 1
EPHA4 EPH receptor A4
FAM117A family with sequence similarity 117, member A
FAM192A family with sequence similarity 192, member A
FGF21 fibroblast growth factor 21
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOXF1 forkhead box F1
FXYD7 FXYD domain containing ion transport regulator 7
GUCA2A guanylate cyclase activator 2A (guanylin)
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HMBOX1 homeobox containing 1
HOXA4 homeobox A4
HPSE heparanase
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IL15RA interleukin 15 receptor, alpha
IRF7 interferon regulatory factor 7
KIFC1 kinesin family member C1
KIFC3 kinesin family member C3
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KLK12 kallikrein-related peptidase 12
LEFTY2 left-right determination factor 2
LOC145678 uncharacterized LOC145678
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAB21L1 mab-21-like 1 (C. elegans)
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MNAT1 MNAT CDK-activating kinase assembly factor 1
MT1HL1 metallothionein 1H-like 1
MT2A metallothionein 2A
MTERF4 mitochondrial transcription termination factor 4
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NELL2 NEL-like 2 (chicken)
NOD1 nucleotide-binding oligomerization domain containing 1
OMG oligodendrocyte myelin glycoprotein
OPRK1 opioid receptor, kappa 1
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OR2H1 olfactory receptor, family 2, subfamily H, member 1
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PNRC1 proline-rich nuclear receptor coactivator 1
PRAMEF11 PRAME family member 11
PRICKLE3 prickle homolog 3 (Drosophila)
PRR4 proline rich 4 (lacrimal)
RABL3 RAB, member of RAS oncogene family-like 3
RCAN2 regulator of calcineurin 2
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RHOF ras homolog family member F (in filopodia)
RPS4Y1 ribosomal protein S4, Y-linked 1
RSG1 REM2 and RAB-like small GTPase 1
SCN1B sodium channel, voltage gated, type I beta subunit
SH2D4A SH2 domain containing 4A
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPEF1 sperm flagellar 1
SSTR4 somatostatin receptor 4
STAG3 stromal antigen 3
SV2A synaptic vesicle glycoprotein 2A
TCP11 t-complex 11, testis-specific
TM4SF5 transmembrane 4 L six family member 5
TMPRSS6 transmembrane protease, serine 6
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TSPAN15 tetraspanin 15
TTC4 tetratricopeptide repeat domain 4
UBE2O ubiquitin-conjugating enzyme E2O
VENTX VENT homeobox
WWC2 WW and C2 domain containing 2
ZBTB22 zinc finger and BTB domain containing 22
ZNF184 zinc finger protein 184
ZNF223 zinc finger protein 223