imatinib-483 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the imatinib-483 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ADAM10 ADAM metallopeptidase domain 10
ADCY9 adenylate cyclase 9
AHI1 Abelson helper integration site 1
API5 apoptosis inhibitor 5
AQP3 aquaporin 3 (Gill blood group)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATXN7 ataxin 7
BAIAP2 BAI1-associated protein 2
C14ORF79 chromosome 14 open reading frame 79
C1ORF54 chromosome 1 open reading frame 54
CA5B carbonic anhydrase VB, mitochondrial
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDC40 cell division cycle 40
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEP250 centrosomal protein 250kDa
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLK1 CDC-like kinase 1
DCSTAMP dendrocyte expressed seven transmembrane protein
EIF1 eukaryotic translation initiation factor 1
EIF5B eukaryotic translation initiation factor 5B
ESR2 estrogen receptor 2 (ER beta)
FBLN1 fibulin 1
FLOT1 flotillin 1
FXR2 fragile X mental retardation, autosomal homolog 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAS8 growth arrest-specific 8
GK glycerol kinase
GMEB1 glucocorticoid modulatory element binding protein 1
GPR107 G protein-coupled receptor 107
HN1L hematological and neurological expressed 1-like
HOXB1 homeobox B1
HSPB3 heat shock 27kDa protein 3
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
INSIG1 insulin induced gene 1
KIF1C kinesin family member 1C
KLK3 kallikrein-related peptidase 3
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LGALS8 lectin, galactoside-binding, soluble, 8
MAN1B1 mannosidase, alpha, class 1B, member 1
MOGAT2 monoacylglycerol O-acyltransferase 2
MST1 macrophage stimulating 1
MTMR3 myotubularin related protein 3
MUC2 mucin 2, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
NCR2 natural cytotoxicity triggering receptor 2
NCS1 neuronal calcium sensor 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NMT1 N-myristoyltransferase 1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PADI2 peptidyl arginine deiminase, type II
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PHOX2B paired-like homeobox 2b
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCL2 phospholipase C-like 2
PRND prion protein 2 (dublet)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3A RAB3A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RBL2 retinoblastoma-like 2
RBM5 RNA binding motif protein 5
RBMX2 RNA binding motif protein, X-linked 2
RGS16 regulator of G-protein signaling 16
RHOBTB3 Rho-related BTB domain containing 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A1 S100 calcium binding protein A1
SETD4 SET domain containing 4
SFSWAP splicing factor, suppressor of white-apricot family
SGSH N-sulfoglucosamine sulfohydrolase
SGSM3 small G protein signaling modulator 3
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SMAD6 SMAD family member 6
SPAG11A sperm associated antigen 11A
SPG20 spastic paraplegia 20 (Troyer syndrome)
ST7L suppression of tumorigenicity 7 like
STAB2 stabilin 2
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYNPO synaptopodin
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBC1D22A TBC1 domain family, member 22A
TBL1Y transducin (beta)-like 1, Y-linked
TFCP2 transcription factor CP2
TMEM176A transmembrane protein 176A
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP53TG1 TP53 target 1 (non-protein coding)
TRIM14 tripartite motif containing 14
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSKU tsukushi, small leucine rich proteoglycan
ZBED4 zinc finger, BED-type containing 4
ZBTB20 zinc finger and BTB domain containing 20
ZNF318 zinc finger protein 318
ZNF551 zinc finger protein 551
ZNF557 zinc finger protein 557

decreased expression

Symbol Name
ADGRE1 adhesion G protein-coupled receptor E1
ADM2 adrenomedullin 2
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMPD1 adenosine monophosphate deaminase 1
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APCS amyloid P component, serum
APOL6 apolipoprotein L, 6
ART3 ADP-ribosyltransferase 3
ASTE1 asteroid homolog 1 (Drosophila)
ATF7IP2 activating transcription factor 7 interacting protein 2
ATXN8OS ATXN8 opposite strand (non-protein coding)
AVPR1B arginine vasopressin receptor 1B
BMPR1B bone morphogenetic protein receptor, type IB
BNC1 basonuclin 1
C19ORF57 chromosome 19 open reading frame 57
C6ORF25 chromosome 6 open reading frame 25
C6ORF47 chromosome 6 open reading frame 47
CAV3 caveolin 3
CCDC176 coiled-coil domain containing 176
CCL16 chemokine (C-C motif) ligand 16
CD101 CD101 molecule
CD53 CD53 molecule
CHAT choline O-acetyltransferase
CLDN17 claudin 17
CORO2B coronin, actin binding protein, 2B
CPA3 carboxypeptidase A3 (mast cell)
CRYAB crystallin, alpha B
CSN2 casein beta
CYBA cytochrome b-245, alpha polypeptide
DAGLA diacylglycerol lipase, alpha
DCC DCC netrin 1 receptor
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHRS11 dehydrogenase/reductase (SDR family) member 11
DISC1 disrupted in schizophrenia 1
DOK3 docking protein 3
EFNA3 ephrin-A3
ERN2 endoplasmic reticulum to nucleus signaling 2
FCGRT Fc fragment of IgG, receptor, transporter, alpha
GDF3 growth differentiation factor 3
GLTSCR1 glioma tumor suppressor candidate region gene 1
GUCA2A guanylate cyclase activator 2A (guanylin)
IL18RAP interleukin 18 receptor accessory protein
IL19 interleukin 19
IL25 interleukin 25
INSL4 insulin-like 4 (placenta)
IRF8 interferon regulatory factor 8
KCNK2 potassium channel, two pore domain subfamily K, member 2
KDM5D lysine (K)-specific demethylase 5D
KLHL3 kelch-like family member 3
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LGALS13 lectin, galactoside-binding, soluble, 13
LINC00574 long intergenic non-protein coding RNA 574
LINC01558 long intergenic non-protein coding RNA 1558
LOC441601 septin 7 pseudogene
LRP3 low density lipoprotein receptor-related protein 3
LRRC32 leucine rich repeat containing 32
MAGEC3 melanoma antigen family C3
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
OLFML2B olfactomedin-like 2B
PDE8B phosphodiesterase 8B
PECR peroxisomal trans-2-enoyl-CoA reductase
PFAS phosphoribosylformylglycinamidine synthase
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PHC1 polyhomeotic homolog 1 (Drosophila)
PLA2G10 phospholipase A2, group X
PLEKHO2 pleckstrin homology domain containing, family O member 2
PNMT phenylethanolamine N-methyltransferase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPEF1 protein phosphatase, EF-hand calcium binding domain 1
PSG11 pregnancy specific beta-1-glycoprotein 11
PSG5 pregnancy specific beta-1-glycoprotein 5
RCAN2 regulator of calcineurin 2
RDH8 retinol dehydrogenase 8 (all-trans)
RXRG retinoid X receptor, gamma
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC46A3 solute carrier family 46, member 3
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
STMN4 stathmin-like 4
T T, brachyury homolog (mouse)
TBC1D29 TBC1 domain family, member 29
TESPA1 thymocyte expressed, positive selection associated 1
TET3 tet methylcytosine dioxygenase 3
TMEM143 transmembrane protein 143
TNS2 tensin 2
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
VIPR1 vasoactive intestinal peptide receptor 1
VSIG4 V-set and immunoglobulin domain containing 4
XYLT1 xylosyltransferase I
ZCCHC6 zinc finger, CCHC domain containing 6
ZMAT3 zinc finger, matrin-type 3
ZNF446 zinc finger protein 446
ZNF671 zinc finger protein 671