imipenem-7294 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the imipenem-7294 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM17 ADAM metallopeptidase domain 17
ADAP2 ArfGAP with dual PH domains 2
AK1 adenylate kinase 1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AP1M2 adaptor-related protein complex 1, mu 2 subunit
ARHGAP26 Rho GTPase activating protein 26
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BCL6 B-cell CLL/lymphoma 6
BICD1 bicaudal D homolog 1 (Drosophila)
BIRC3 baculoviral IAP repeat containing 3
C6ORF10 chromosome 6 open reading frame 10
CA9 carbonic anhydrase IX
CCNG2 cyclin G2
CCR2 chemokine (C-C motif) receptor 2
CD4 CD4 molecule
CDK13 cyclin-dependent kinase 13
CEP162 centrosomal protein 162kDa
CISH cytokine inducible SH2-containing protein
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COL3A1 collagen, type III, alpha 1
COL7A1 collagen, type VII, alpha 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CUL7 cullin 7
CXCL5 chemokine (C-X-C motif) ligand 5
CYHR1 cysteine/histidine-rich 1
DTNA dystrobrevin, alpha
DTX3 deltex 3, E3 ubiquitin ligase
DUSP8 dual specificity phosphatase 8
E2F4 E2F transcription factor 4, p107/p130-binding
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF3M eukaryotic translation initiation factor 3, subunit M
EPHX2 epoxide hydrolase 2, cytoplasmic
ETV6 ets variant 6
FGF5 fibroblast growth factor 5
FLJ11292
GOLGA2 golgin A2
GPC1 glypican 1
GPR17 G protein-coupled receptor 17
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFITM1 interferon induced transmembrane protein 1
IFT27 intraflagellar transport 27
IPO8 importin 8
KAZN kazrin, periplakin interacting protein
KHK ketohexokinase (fructokinase)
KRT6B keratin 6B, type II
LRP4 low density lipoprotein receptor-related protein 4
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MDFIC MyoD family inhibitor domain containing
MEF2D myocyte enhancer factor 2D
METTL7A methyltransferase like 7A
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MX1 MX dynamin-like GTPase 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYRF myelin regulatory factor
NDE1 nudE neurodevelopment protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PHF20L1 PHD finger protein 20-like 1
PIP prolactin-induced protein
PRKCA protein kinase C, alpha
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SBNO2 strawberry notch homolog 2 (Drosophila)
SCG5 secretogranin V
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIDT2 SID1 transmembrane family, member 2
SIRT5 sirtuin 5
SLC22A14 solute carrier family 22, member 14
SLMO1 slowmo homolog 1 (Drosophila)
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYT11 synaptotagmin XI
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TCF12 transcription factor 12
THOC5 THO complex 5
TMEM63A transmembrane protein 63A
TRAK1 trafficking protein, kinesin binding 1
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIO trio Rho guanine nucleotide exchange factor
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VNN1 vanin 1
WDR25 WD repeat domain 25
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF675 zinc finger protein 675
ZNF85 zinc finger protein 85

decreased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AP1AR adaptor-related protein complex 1 associated regulatory protein
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ATAD2B ATPase family, AAA domain containing 2B
ATAD3A ATPase family, AAA domain containing 3A
ATP7B ATPase, Cu++ transporting, beta polypeptide
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAG4 BCL2-associated athanogene 4
BAHD1 bromo adjacent homology domain containing 1
BORA bora, aurora kinase A activator
C17ORF80 chromosome 17 open reading frame 80
CAMTA2 calmodulin binding transcription activator 2
CCDC68 coiled-coil domain containing 68
CCRL2 chemokine (C-C motif) receptor-like 2
CEP72 centrosomal protein 72kDa
CFAP69 cilia and flagella associated protein 69
CHST10 carbohydrate sulfotransferase 10
CINP cyclin-dependent kinase 2 interacting protein
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DGAT1 diacylglycerol O-acyltransferase 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DLK1 delta-like 1 homolog (Drosophila)
DLK2 delta-like 2 homolog (Drosophila)
EFNA3 ephrin-A3
EXOC3 exocyst complex component 3
FAM188A family with sequence similarity 188, member A
FBXL4 F-box and leucine-rich repeat protein 4
FGD6 FYVE, RhoGEF and PH domain containing 6
FPGS folylpolyglutamate synthase
FSD1 fibronectin type III and SPRY domain containing 1
FZD3 frizzled class receptor 3
GPATCH2L G patch domain containing 2-like
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H2AM histone cluster 1, H2am
HMOX1 heme oxygenase 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IL11RA interleukin 11 receptor, alpha
INF2 inverted formin, FH2 and WH2 domain containing
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0232 KIAA0232
KIFC1 kinesin family member C1
KIRREL kin of IRRE like (Drosophila)
LNPEP leucyl/cystinyl aminopeptidase
LOC100127972 uncharacterized LOC100127972
LSR lipolysis stimulated lipoprotein receptor
LZTR1 leucine-zipper-like transcription regulator 1
MANBA mannosidase, beta A, lysosomal
MAP1S microtubule-associated protein 1S
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL2B methyltransferase like 2B
MFGE8 milk fat globule-EGF factor 8 protein
MITF microphthalmia-associated transcription factor
NBEAL2 neurobeachin-like 2
NDRG4 NDRG family member 4
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
ODF2 outer dense fiber of sperm tails 2
OGFRL1 opioid growth factor receptor-like 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P3H2 prolyl 3-hydroxylase 2
PDE12 phosphodiesterase 12
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCD1 phospholipase C, delta 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PNRC1 proline-rich nuclear receptor coactivator 1
POR P450 (cytochrome) oxidoreductase
RAB8B RAB8B, member RAS oncogene family
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
REPS2 RALBP1 associated Eps domain containing 2
RPAP2 RNA polymerase II associated protein 2
RPP25 ribonuclease P/MRP 25kDa subunit
RPS17P5 ribosomal protein S17 pseudogene 5
SCAI suppressor of cancer cell invasion
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SECISBP2 SECIS binding protein 2
SLC22A18 solute carrier family 22, member 18
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRBD1 S1 RNA binding domain 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAR steroidogenic acute regulatory protein
STARD3 StAR-related lipid transfer (START) domain containing 3
TBC1D19 TBC1 domain family, member 19
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNNI3 troponin I type 3 (cardiac)
TPST2 tyrosylprotein sulfotransferase 2
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
USB1 U6 snRNA biogenesis 1
WNT7A wingless-type MMTV integration site family, member 7A
ZC3H12A zinc finger CCCH-type containing 12A
ZNF197 zinc finger protein 197
ZNF230 zinc finger protein 230
ZNF34 zinc finger protein 34
ZNF385D zinc finger protein 385D