imipramine-1685 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the imipramine-1685 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
AIF1 allograft inflammatory factor 1
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APC adenomatous polyposis coli
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ATAD5 ATPase family, AAA domain containing 5
ATG4B autophagy related 4B, cysteine peptidase
ATM ATM serine/threonine kinase
BAIAP2 BAI1-associated protein 2
C19ORF73 chromosome 19 open reading frame 73
CD83 CD83 molecule
CDC14B cell division cycle 14B
CDKN2A cyclin-dependent kinase inhibitor 2A
CEP104 centrosomal protein 104kDa
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
COMMD4 COMM domain containing 4
COPZ2 coatomer protein complex, subunit zeta 2
CPNE7 copine VII
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CUEDC1 CUE domain containing 1
CYHR1 cysteine/histidine-rich 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DCTN1 dynactin 1
EGFL7 EGF-like-domain, multiple 7
EPHB4 EPH receptor B4
ETV5 ets variant 5
EXOC7 exocyst complex component 7
FADS3 fatty acid desaturase 3
FBXL15 F-box and leucine-rich repeat protein 15
FBXL7 F-box and leucine-rich repeat protein 7
FBXO11 F-box protein 11
FBXO31 F-box protein 31
FCF1 FCF1 rRNA-processing protein
FGFR2 fibroblast growth factor receptor 2
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
FOXN3 forkhead box N3
FOXO1 forkhead box O1
FURIN furin (paired basic amino acid cleaving enzyme)
GAS6 growth arrest-specific 6
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GM2A GM2 ganglioside activator
GOSR2 golgi SNAP receptor complex member 2
GPR27 G protein-coupled receptor 27
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HN1L hematological and neurological expressed 1-like
HPSE heparanase
INO80D INO80 complex subunit D
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITSN1 intersectin 1 (SH3 domain protein)
JADE1 jade family PHD finger 1
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KDM4C lysine (K)-specific demethylase 4C
KIZ kizuna centrosomal protein
LINC00115 long intergenic non-protein coding RNA 115
LRRC61 leucine rich repeat containing 61
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METTL16 methyltransferase like 16
MTA2 metastasis associated 1 family, member 2
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
N4BP1 NEDD4 binding protein 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NCALD neurocalcin delta
NCOA2 nuclear receptor coactivator 2
NDE1 nudE neurodevelopment protein 1
NKX3-1 NK3 homeobox 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
OSGIN1 oxidative stress induced growth inhibitor 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLK4 polo-like kinase 4
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
QPCTL glutaminyl-peptide cyclotransferase-like
RAD54L2 RAD54-like 2 (S. cerevisiae)
RANBP3 RAN binding protein 3
RBM3 RNA binding motif (RNP1, RRM) protein 3
SEC14L1 SEC14-like 1 (S. cerevisiae)
SFXN3 sideroflexin 3
SLC22A17 solute carrier family 22, member 17
SNAI2 snail family zinc finger 2
SNCG synuclein, gamma (breast cancer-specific protein 1)
STK16 serine/threonine kinase 16
TADA2A transcriptional adaptor 2A
TAZ tafazzin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM53 transmembrane protein 53
TPR translocated promoter region, nuclear basket protein
TSC22D4 TSC22 domain family, member 4
TWF1 twinfilin actin binding protein 1
USB1 U6 snRNA biogenesis 1
VASH2 vasohibin 2
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZFPL1 zinc finger protein-like 1

decreased expression

Symbol Name
ACTN4 actinin, alpha 4
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ACVR2B activin A receptor, type IIB
ADRA2C adrenoceptor alpha 2C
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGAP10 Rho GTPase activating protein 10
ARMC6 armadillo repeat containing 6
ARRB1 arrestin, beta 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAHD1 bromo adjacent homology domain containing 1
C5ORF45 chromosome 5 open reading frame 45
CAMTA2 calmodulin binding transcription activator 2
CCNO cyclin O
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEP72 centrosomal protein 72kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHKB choline kinase beta
CHMP6 charged multivesicular body protein 6
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CXORF56 chromosome X open reading frame 56
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEAF1 DEAF1 transcription factor
DOCK1 dedicator of cytokinesis 1
DSCAM Down syndrome cell adhesion molecule
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ERCC5 excision repair cross-complementation group 5
FAAH fatty acid amide hydrolase
FAM63A family with sequence similarity 63, member A
FIP1L1 factor interacting with PAPOLA and CPSF1
FLCN folliculin
FLJ22184
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H2AG histone cluster 1, H2ag
IP6K1 inositol hexakisphosphate kinase 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IRF2BP1 interferon regulatory factor 2 binding protein 1
JUNB jun B proto-oncogene
KLC2 kinesin light chain 2
LAMB3 laminin, beta 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LOC730101 uncharacterized LOC730101
LRRC37A2 leucine rich repeat containing 37, member A2
MAMLD1 mastermind-like domain containing 1
MB myoglobin
MBTPS2 membrane-bound transcription factor peptidase, site 2
MECR mitochondrial trans-2-enoyl-CoA reductase
METTL2B methyltransferase like 2B
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MYL5 myosin, light chain 5, regulatory
NMU neuromedin U
NPFFR1 neuropeptide FF receptor 1
NPIPB15 nuclear pore complex interacting protein family, member B15
OLFML3 olfactomedin-like 3
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCDHB3 protocadherin beta 3
PCSK7 proprotein convertase subtilisin/kexin type 7
PHACTR4 phosphatase and actin regulator 4
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G10 phospholipase A2, group X
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR15L proline rich 15-like
PTK6 protein tyrosine kinase 6
PTPRU protein tyrosine phosphatase, receptor type, U
QTRT1 queuine tRNA-ribosyltransferase 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB3A RAB3A, member RAS oncogene family
RASA2 RAS p21 protein activator 2
RFTN1 raftlin, lipid raft linker 1
RPAP1 RNA polymerase II associated protein 1
S100A4 S100 calcium binding protein A4
SAMHD1 SAM domain and HD domain 1
SH2D4A SH2 domain containing 4A
SIRAL2 SIR2 antiphage like 2
SLC16A6 solute carrier family 16, member 6
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNHG20 small nucleolar RNA host gene 20
SOX12 SRY (sex determining region Y)-box 12
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBL3 transducin (beta)-like 3
TEAD3 TEA domain family member 3
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM110 transmembrane protein 110
TMEM180 transmembrane protein 180
TMEM254 transmembrane protein 254
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
UBE2O ubiquitin-conjugating enzyme E2O
ZC3H12A zinc finger CCCH-type containing 12A
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZDHHC4 zinc finger, DHHC-type containing 4
ZMYM3 zinc finger, MYM-type 3
ZNF212 zinc finger protein 212
ZNF408 zinc finger protein 408