imipramine-1849 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the imipramine-1849 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADAM23 ADAM metallopeptidase domain 23
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AEN apoptosis enhancing nuclease
AIM2 absent in melanoma 2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BICD1 bicaudal D homolog 1 (Drosophila)
BIK BCL2-interacting killer (apoptosis-inducing)
BOLA1 bolA family member 1
BTBD7 BTB (POZ) domain containing 7
C1ORF56 chromosome 1 open reading frame 56
C9ORF3 chromosome 9 open reading frame 3
CACTIN cactin, spliceosome C complex subunit
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCDC71 coiled-coil domain containing 71
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDCP1 CUB domain containing protein 1
CDK3 cyclin-dependent kinase 3
CDR2L cerebellar degeneration-related protein 2-like
CFAP45 cilia and flagella associated protein 45
CHKA choline kinase alpha
CLCN4 chloride channel, voltage-sensitive 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CSF1 colony stimulating factor 1 (macrophage)
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CXCL10 chemokine (C-X-C motif) ligand 10
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOK3 docking protein 3
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOC2 exocyst complex component 2
FLJ42627 uncharacterized LOC645644
FOXO4 forkhead box O4
FUZ fuzzy planar cell polarity protein
GAMT guanidinoacetate N-methyltransferase
GSN gelsolin
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMGXB3 HMG box domain containing 3
HRH1 histamine receptor H1
HSPA4 heat shock 70kDa protein 4
IQCK IQ motif containing K
IQSEC1 IQ motif and Sec7 domain 1
KIAA1456 KIAA1456
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRIT1 KRIT1, ankyrin repeat containing
KRT8P12 keratin 8 pseudogene 12
L2HGDH L-2-hydroxyglutarate dehydrogenase
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LMNA lamin A/C
MAGED2 melanoma antigen family D2
MAP7 microtubule-associated protein 7
MIIP migration and invasion inhibitory protein
MLH3 mutL homolog 3
MST1 macrophage stimulating 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NIPAL2 NIPA-like domain containing 2
NT5DC3 5'-nucleotidase domain containing 3
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
OVGP1 oviductal glycoprotein 1, 120kDa
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PCGF2 polycomb group ring finger 2
PCM1 pericentriolar material 1
PENK proenkephalin
PHACTR1 phosphatase and actin regulator 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLD1 phospholipase D1, phosphatidylcholine-specific
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
RAB3A RAB3A, member RAS oncogene family
RBM19 RNA binding motif protein 19
RNFT1 ring finger protein, transmembrane 1
RPAIN RPA interacting protein
RPL35A ribosomal protein L35a
RPL5 ribosomal protein L5
RRBP1 ribosome binding protein 1
RUNX1 runt-related transcription factor 1
SCAI suppressor of cancer cell invasion
SIDT2 SID1 transmembrane family, member 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC22A14 solute carrier family 22, member 14
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMG7 SMG7 nonsense mediated mRNA decay factor
SORT1 sortilin 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
STMN1 stathmin 1
SUGP1 SURP and G patch domain containing 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TLDC1 TBC/LysM-associated domain containing 1
TNK2 tyrosine kinase, non-receptor, 2
TOB2 transducer of ERBB2, 2
USF2 upstream transcription factor 2, c-fos interacting
UTRN utrophin

decreased expression

Symbol Name
ADGRE2 adhesion G protein-coupled receptor E2
AGBL5 ATP/GTP binding protein-like 5
AGO4 argonaute RISC catalytic component 4
AKTIP AKT interacting protein
ARMC7 armadillo repeat containing 7
ATAD5 ATPase family, AAA domain containing 5
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BBS10 Bardet-Biedl syndrome 10
C22ORF46 chromosome 22 open reading frame 46
CD3EAP CD3e molecule, epsilon associated protein
CD82 CD82 molecule
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CFAP44 cilia and flagella associated protein 44
CINP cyclin-dependent kinase 2 interacting protein
CRY2 cryptochrome circadian clock 2
CSF1R colony stimulating factor 1 receptor
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DZANK1 double zinc ribbon and ankyrin repeat domains 1
FAM188A family with sequence similarity 188, member A
FAM53B family with sequence similarity 53, member B
FLCN folliculin
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GIPC1 GIPC PDZ domain containing family, member 1
GPR63 G protein-coupled receptor 63
IFITM2 interferon induced transmembrane protein 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KIAA0319L KIAA0319-like
KLF11 Kruppel-like factor 11
KLHL21 kelch-like family member 21
LAX1 lymphocyte transmembrane adaptor 1
LINC00597 long intergenic non-protein coding RNA 597
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LY6E lymphocyte antigen 6 complex, locus E
LYPLA2P1 lysophospholipase II pseudogene 1
MAN2C1 mannosidase, alpha, class 2C, member 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCM3AP-AS1 MCM3AP antisense RNA 1
MCMBP minichromosome maintenance complex binding protein
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYNN myoneurin
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PIR pirin (iron-binding nuclear protein)
PLA2G15 phospholipase A2, group XV
PYCR1 pyrroline-5-carboxylate reductase 1
QTRT1 queuine tRNA-ribosyltransferase 1
RAB33B RAB33B, member RAS oncogene family
RBM41 RNA binding motif protein 41
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFX7 regulatory factor X, 7
RNF122 ring finger protein 122
RPAP1 RNA polymerase II associated protein 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SDHAF3 succinate dehydrogenase complex assembly factor 3
SERINC5 serine incorporator 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SNX17 sorting nexin 17
SPAG4 sperm associated antigen 4
SRD5A3 steroid 5 alpha-reductase 3
SSBP3 single stranded DNA binding protein 3
STXBP1 syntaxin binding protein 1
SURF2 surfeit 2
TAOK1 TAO kinase 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM159 transmembrane protein 159
TOM1 target of myb1 (chicken)
TRAPPC11 trafficking protein particle complex 11
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TTBK2 tau tubulin kinase 2
TUBA3C tubulin, alpha 3c
TXLNG taxilin gamma
URGCP upregulator of cell proliferation
USB1 U6 snRNA biogenesis 1
USP19 ubiquitin specific peptidase 19
WT1-AS WT1 antisense RNA
XAF1 XIAP associated factor 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB44 zinc finger and BTB domain containing 44
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H3 zinc finger CCCH-type containing 3
ZFYVE21 zinc finger, FYVE domain containing 21
ZNF10 zinc finger protein 10
ZNF16 zinc finger protein 16
ZNF197 zinc finger protein 197
ZNF227 zinc finger protein 227
ZNF253 zinc finger protein 253
ZNF675 zinc finger protein 675
ZNF8 zinc finger protein 8
ZNRD1-AS1 ZNRD1 antisense RNA 1