impaired fertilization Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei (Mammalian Phenotype Ontology, MP_0000242)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000242
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Genes

64 gene mutations causing the impaired fertilization phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACRBP acrosin binding protein
ADAD1 adenosine deaminase domain containing 1 (testis-specific)
ADCY3 adenylate cyclase 3
AGFG1 ArfGAP with FG repeats 1
AMBP alpha-1-microglobulin/bikunin precursor
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
BRWD1 bromodomain and WD repeat domain containing 1
CALR3 calreticulin 3
CATSPER1 cation channel, sperm associated 1
CATSPER2 cation channel, sperm associated 2
CD9 CD9 molecule
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLGN calmegin
CPLX1 complexin 1
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
EPHB6 EPH receptor B6
ESR1 estrogen receptor 1
FETUB fetuin B
FKBP4 FK506 binding protein 4, 59kDa
GLRA1 glycine receptor, alpha 1
GLRB glycine receptor, beta
GOLGA3 golgin A3
GOPC golgi-associated PDZ and coiled-coil motif containing
GPX4 glutathione peroxidase 4
GRID2 glutamate receptor, ionotropic, delta 2
H1FNT H1 histone family, member N, testis-specific
HEXB hexosaminidase B (beta polypeptide)
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IZUMO1 izumo sperm-egg fusion 1
KCNU1 potassium channel, subfamily U, member 1
LDHC lactate dehydrogenase C
MMEL1 membrane metallo-endopeptidase-like 1
NDC1 NDC1 transmembrane nucleoporin
NPC1 Niemann-Pick disease, type C1
NPHP4 nephronophthisis 4
PABPC1L poly(A) binding protein, cytoplasmic 1-like
PCSK4 proprotein convertase subtilisin/kexin type 4
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G3 phospholipase A2, group III
PLTP phospholipid transfer protein
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRND prion protein 2 (dublet)
PRNP prion protein
PRSS21 protease, serine, 21 (testisin)
PRSS37 protease, serine, 37
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RIMBP3 RIMS binding protein 3
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
SEC23IP SEC23 interacting protein
SMCP sperm mitochondria-associated cysteine-rich protein
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPEM1 spermatid maturation 1
TALDO1 transaldolase 1
TGM4 transglutaminase 4
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRPV6 transient receptor potential cation channel, subfamily V, member 6
USP2 ubiquitin specific peptidase 2
WIPF3 WAS/WASL interacting protein family, member 3