incomplete rostral neuropore closure Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description arrest of the fusion of the cephalic neural folds (Mammalian Phenotype Ontology, MP_0000928)
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61 gene mutations causing the incomplete rostral neuropore closure phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AMT aminomethyltransferase
ARHGAP35 Rho GTPase activating protein 35
AXIN1 axin 1
BMP2 bone morphogenetic protein 2
CALR calreticulin
CCDC160 coiled-coil domain containing 160
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CREBBP CREB binding protein
CSK c-src tyrosine kinase
CSNK2A1 casein kinase 2, alpha 1 polypeptide
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EFNA5 ephrin-A5
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FZD3 frizzled class receptor 3
GATAD2A GATA zinc finger domain containing 2A
GCM2 glial cells missing homolog 2 (Drosophila)
GLI3 GLI family zinc finger 3
GRHL2 grainyhead-like 2 (Drosophila)
HES1 hes family bHLH transcription factor 1
HUS1 HUS1 checkpoint homolog (S. pombe)
IFT57 intraflagellar transport 57
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
JARID2 jumonji, AT rich interactive domain 2
KAT2A K(lysine) acetyltransferase 2A
KDM2B lysine (K)-specific demethylase 2B
LAMA5 laminin, alpha 5
LMO4 LIM domain only 4
LUZP1 leucine zipper protein 1
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKS1 Meckel syndrome, type 1
MTTP microsomal triglyceride transfer protein
NOG noggin
NR6A1 nuclear receptor subfamily 6, group A, member 1
OVOL2 ovo-like zinc finger 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX2 paired box 2
PAX3 paired box 3
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLXNB2 plexin B2
POR P450 (cytochrome) oxidoreductase
PTCH1 patched 1
RERE arginine-glutamic acid dipeptide (RE) repeats
RGMA repulsive guidance molecule family member a
RPL38 ribosomal protein L38
RTEL1 regulator of telomere elongation helicase 1
SMAD5 SMAD family member 5
SP8 Sp8 transcription factor
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM67 transmembrane protein 67
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase
TSC2 tuberous sclerosis 2
TULP3 tubby like protein 3
TXN2 thioredoxin 2
UNC5B unc-5 homolog B (C. elegans)
VCL vinculin
YBX1 Y box binding protein 1
ZIC2 Zic family member 2