increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Gene Set

Dataset MGI Mouse Phenotype Associations 2023
Category disease or phenotype associations
Type phenotype
Description a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release (Mammalian Phenotype Ontology, MP_0010168)
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Genes

23 gene mutations causing the increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

Symbol Name
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
C9ORF72 chromosome 9 open reading frame 72
CD22 CD22 molecule
COG6 component of oligomeric golgi complex 6
DIAPH1 diaphanous-related formin 1
DPH6 diphthamine biosynthesis 6
DUOXA2 dual oxidase maturation factor 2
FAM83H family with sequence similarity 83, member H
HBS1L HBS1-like translational GTPase
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LTN1 listerin E3 ubiquitin protein ligase 1
MMP20 matrix metallopeptidase 20
NCF2 neutrophil cytosolic factor 2
NUP210 nucleoporin 210kDa
PAX5 paired box 5
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene)
SIK3 SIK family kinase 3
SPRED1 sprouty-related, EVH1 domain containing 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
THEMIS thymocyte selection associated
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZSCAN10 zinc finger and SCAN domain containing 10