increased cardiac muscle contractility Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume (Mammalian Phenotype Ontology, MP_0005599)
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27 gene mutations causing the increased cardiac muscle contractility phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ANXA6 annexin A6
ARRB1 arrestin, beta 1
ASPH aspartate beta-hydroxylase
BRAF B-Raf proto-oncogene, serine/threonine kinase
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FXYD1 FXYD domain containing ion transport regulator 1
GATA5 GATA binding protein 5
IGF1 insulin-like growth factor 1 (somatomedin C)
KLF3 Kruppel-like factor 3 (basic)
MMP9 matrix metallopeptidase 9
MYBPC3 myosin binding protein C, cardiac
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
PDC phosducin
PDE4D phosphodiesterase 4D, cAMP-specific
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAU plasminogen activator, urokinase
PLN phospholamban
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
SFRP2 secreted frizzled-related protein 2
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLN sarcolipin
TBX3 T-box 3