increased cellular sensitivity to oxidative stress Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis (Mammalian Phenotype Ontology, MP_0008412)
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35 gene mutations causing the increased cellular sensitivity to oxidative stress phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHSP alpha hemoglobin stabilizing protein
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATMIN ATM interactor
CC2D1A coiled-coil and C2 domain containing 1A
CCS copper chaperone for superoxide dismutase
CLP1 cleavage and polyadenylation factor I subunit 1
CP ceruloplasmin (ferroxidase)
CRYBB2 crystallin, beta B2
CTH cystathionine gamma-lyase
ERCC1 excision repair cross-complementation group 1
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GPX1 glutathione peroxidase 1
GPX7 glutathione peroxidase 7
MAPKAP1 mitogen-activated protein kinase associated protein 1
MIR144 microRNA 144
MIR451A microRNA 451a
MTFR1 mitochondrial fission regulator 1
NFE2L2 nuclear factor, erythroid 2-like 2
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
REG1B regenerating islet-derived 1 beta
RGN regucalcin
RIT1 Ras-like without CAAX 1
SESN2 sestrin 2
SIRT7 sirtuin 7
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
STC2 stanniocalcin 2
UNG uracil-DNA glycosylase
VASN vasorin
WRN Werner syndrome, RecQ helicase-like
ZFP36 ZFP36 ring finger protein