increased cellular sensitivity to ultraviolet irradiation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater incidence of cell death following exposure to ultraviolet irradiation (Mammalian Phenotype Ontology, MP_0008410)
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24 gene mutations causing the increased cellular sensitivity to ultraviolet irradiation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATR ATR serine/threonine kinase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHD2 chromodomain helicase DNA binding protein 2
CUL4A cullin 4A
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC6 excision repair cross-complementation group 6
ERCC8 excision repair cross-complementation group 8
HMGN1 high mobility group nucleosome binding domain 1
ING1 inhibitor of growth family, member 1
JUND jun D proto-oncogene
POLK polymerase (DNA directed) kappa
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
SIRT1 sirtuin 1
TP53 tumor protein p53
TROVE2 TROVE domain family, member 2
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP47 ubiquitin specific peptidase 47
VASN vasorin
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C